π¦ Jason Weirather Email and Phone Number
I have a passion for exploring big data and learning more about the complex biology of the immune system. At the DFCI Center for Immuno-Oncology (CIO), under the leadership of Dr. F Steven Hodi and Dr. Mohamed Uduman, I have the opportunity to explore data alongside clinicians and scientists to better understand immuno-therapies with the goal of improving the care we can provide patients. I have worked with bioinformaticians and pathologists at DFCI to build and maintain a pipeline for multiplex-Immunofluorescence (mIF) image analysis capable of taking segmented and phenotyped images and producing both sample-level summary statistics and spatial analyses. This pipeline has served as a backbone for the analysis of research projects, and has also been integrated in the institutional effort to provide a standardized analysis of mIF data known as Immuno-Profile.The CIO is a member of the CIMAC-CIDC trials network comprised of multiple institutions working together to standardize the acquisition and analysis of immuno-therapy trials data. Under the leadership of Dr. Ethan Cerami and Dr. Shirley Liu, I contribute to the development of the analytical pipeline which will provide immuno-therapy-specialized analyses for mIF, IHC, RNA-seq, WES, mass cytometry (CyTOF), and serum-protein (Olink) data.
Elucidate Bio
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Director Of Computational BiologyElucidate BioBoston, Ma, Us -
Lead ScientistDana-Farber Cancer Institute Sep 2021 - PresentBoston, Massachusetts, United StatesImmunotherapy has revolutionized treatments of many advanced stage cancers, but fundamental questions remain: 1) Which biomarkers are informative for identifying patients that will benefit from therapy? 2) What are the mechanisms of resistance to immunotherapy? 3) How can we mitigate the toxicity that can accompany these treatments? Our team provides clinicians and scientists at the DFCI Center for Immuno-Oncology (CIO) computational tools and expertise they need to answer these questions with the goal of improving the care patients receive. -
Senior ScientistDana-Farber Cancer Institute Jan 2020 - Sep 2021Boston, Massachusetts, United StatesMy responsibilities include leading the maintenance and development of our image analysis pipeline for multiplex-Immunofluorescence (mIF) assays, contributing to cross-institutional efforts to generate standardized assays and analyses for immunotherapy trials (CIMAC-CIDC trials network), and mentoring translational bioinformatics research. -
Bioinformatics Engineer IiDana-Farber Cancer Institute Apr 2017 - Jan 2020Immuno-therapy has revolutionized treatments of many advanced stage cancers, but fundamental questions remain: 1) Which biomarkers are informative for identifying patients that will benefit from therapy? 2) What are the mechanisms of resistance to immuno-therapy? 3) How can we mitigate the toxicity that can accompany these treatments? I work with the clinicians and scientists at the DFCI Center for Immuno-Oncology to find answers to these questions with the goal of improving the care patients receive. -
Postdoctoral Research FellowUniversity Of Iowa 2014 - 2017Third Generation Sequencing (TGS) technologies such as those from Pacific Biosciences and Oxford Nanopore Technologies can generate full-length sequences from transcripts. My research lead by Dr. Kin Fai Au (now at The Ohio State University) involved developing tools for structural variation in cancers that leverages the long reads from TGS technologies to identify gene-fusion events at the transcript level with higher specificity than Second Generation Sequencing alone. I also developed QC software to measure and visualize the error rates and coverage of TGS sequencing data. -
Healthcare Specialist (E4)Army National Guard 2003 - 2009Iowa City, Iowa Area
π¦ Jason Weirather Education Details
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Genetics -
Electrical Engineering
Frequently Asked Questions about π¦ Jason Weirather
What company does π¦ Jason Weirather work for?
π¦ Jason Weirather works for Elucidate Bio
What is π¦ Jason Weirather's role at the current company?
π¦ Jason Weirather's current role is Director of Computational Biology.
What schools did π¦ Jason Weirather attend?
π¦ Jason Weirather attended University Of Iowa, Iowa State University.
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