Jason Lin Email & Phone Number

London, England, United Kingdom

• Executed process transfer of viral vector processes (rAAV and lentivirus vector) between bench-top bioreactor systems from 250 mL to 10 L by scaling process parameters.• Generated rAAV material using the 2L Univessel system and communicated progress reports with external stakeholders.• Optimized high-throughput downstream processing of rAAV samples, achieving purified samples for mass photometer characterization of % full capsid through lab automation.• Pioneered the establishment… Show more • Executed process transfer of viral vector processes (rAAV and lentivirus vector) between bench-top bioreactor systems from 250 mL to 10 L by scaling process parameters.• Generated rAAV material using the 2L Univessel system and communicated progress reports with external stakeholders.• Optimized high-throughput downstream processing of rAAV samples, achieving purified samples for mass photometer characterization of % full capsid through lab automation.• Pioneered the establishment of a ribonucleoprotein-based CRISPR/Cas9 workflow for HEK cell line engineering.• Analyzed next-generation sequencing and pathway enrichment data to aid target selection for genetic engineering.• Conducted DoE studies on novel synthetic DNA constructs for rAAV production, overseeing progress, risk registering, and disseminating information to external stakeholders of an iUK sponsor collaboration project.• Represented the technical team through poster presentations at ESGCT and BSGCT annual conferences. Show less

• Led the generation of a GMP-ready HEK research cell bank for rAAV production, gaining practical experience in regulatory requirements of GMP cell bank development.• Developed a semi-automated high-throughput mammalian cell processing workflow for screening clonal cell lines for rAAV production.• Implemented sample management and data tracking workflow using a barcode-labelled tube storage lab infrastructure.• Engineered a lentiviral-based inducible CRISPR/Cas9 workflow for HEK… Show more • Led the generation of a GMP-ready HEK research cell bank for rAAV production, gaining practical experience in regulatory requirements of GMP cell bank development.• Developed a semi-automated high-throughput mammalian cell processing workflow for screening clonal cell lines for rAAV production.• Implemented sample management and data tracking workflow using a barcode-labelled tube storage lab infrastructure.• Engineered a lentiviral-based inducible CRISPR/Cas9 workflow for HEK cell line engineering.• Established flow cytometry and simple western assay for Cas9 protein detection.• Identified skill gaps within the team and conducted training sessions and materials to upskill junior team members. Show less

• Conducted DoE studies to optimize transfection parameters on the Ambr15 system, resulting in increase in rAAV process productivity.• Gained proficiency in a range of analytical techniques, including droplet digital PCR (ddPCR), enzyme-linked immunosorbent assay (ELISA), and multi-colour flow cytometry panels.• Designed and executed experiments on rAAV process innovation to achieve project milestones, demonstrating strong problem-solving and analytical skills.• Coordinated… Show more • Conducted DoE studies to optimize transfection parameters on the Ambr15 system, resulting in increase in rAAV process productivity.• Gained proficiency in a range of analytical techniques, including droplet digital PCR (ddPCR), enzyme-linked immunosorbent assay (ELISA), and multi-colour flow cytometry panels.• Designed and executed experiments on rAAV process innovation to achieve project milestones, demonstrating strong problem-solving and analytical skills.• Coordinated laboratory activities to ensure timely completion of experiments and efficient use of resources. Show less

London, England, United Kingdom

• Optimized in-house adeno-associated virus (AAV) viral vector production on the Ambr250 system, evaluating different combinations of critical process materials such as cell lines, DNA constructs, viral delivery method, and bioreactor operation parameters.• Operated the Ambr250 bioreactor system and conducted single-color flow cytometry analysis for cell characterization.• Analyzed experimental data and generated actionable insights to inform process improvements through internal… Show more • Optimized in-house adeno-associated virus (AAV) viral vector production on the Ambr250 system, evaluating different combinations of critical process materials such as cell lines, DNA constructs, viral delivery method, and bioreactor operation parameters.• Operated the Ambr250 bioreactor system and conducted single-color flow cytometry analysis for cell characterization.• Analyzed experimental data and generated actionable insights to inform process improvements through internal biweekly updates. Show less

Taipei City, Taiwan

Cultivated and sustained interpersonal connections with key stakeholders throughout the regional area.Contributed insights on market dynamics and trends during quarterly review meetings.

Master Of Science - Ms, Genes, Drugs, And Stem Cells - Novel Therapies

Graduated with high merit (68.5/100) Focused on gene and nucleic acid-based therapy.

Bachelor Of Science - Bs, Biomedical Science And Engineering, 3.7/4.0 Gpa

Education record

Activities and Societies: Spring term exchange program

Mba Essentials Certification, Business Administration And Management, General

The MBA Essentials online certificate from LSE provides comprehensive skills in strategy, finance, and leadership. It combines theory.