Jason L. Email & Phone Number

Chicago, IL, US

Chicago, IL, US

Advisors: Dr. Matthew Tirrell and Dr. Yun Fang

Seattle, WA, US

• TLC-ART Program under Dr. Rodney Ho
• Optimize lipid nanoparticle (LNP) platform containing 3+ antiretroviral APIs to simultaneously act on HIV-host cells
• Quantify long-acting drug release profile and morphology using analytical assays including RP-HPLC, LC-MS, and XRD
• Develop analytical methods and troubleshoot lipid quantification of lipid nanoparticles through HPLC-CAD
• Investigate lipid-drug interactions for the development of drug product formulations for use in pre-clinical trials

South San Francisco, California, US

• Investigated the impact of counter-ions on particle formation and antibody stability through FlowCAM and SEC-HPLC
• Independently designed and executed long-term stability studies to support IND and patent application for pipeline molecule
• Explored self-association mechanics of bispecific antibody and surfactant binding through dynamic light scattering (DLS), isothermal calorimetry (ITC), and microscale thermophoresis (MST).

Ann Arbor, MI, US

• Cardiac Biomechanics Lab under Dr. David Nordsletten
• Created personalized segmented image masks of in vitro cardiac microtissues for finite element analysis
• Utilized mathematical model for the evaluation of mechanical properties of IPSC derived cardiomyocyte microtissues
• Investigated effects of fiber and cell orientation on properties of cardiac microtissue

Ann Arbor, Michigan, US

• Simulated fluid mechanics profile of over 10 wearable sweat-collection device using COMSOL to guide future design iterations

Indianapolis, Indiana, US

• Established a database for materials of composition of closed system transfer devices for use in future compatibility studies
• Optimized the allowable excess volume for drug product vials according to USP <1> Injections to ensure sufficient dosing
• Evaluated chemical and physical compatibility of drug product with various closed system transfer devices (CSTDs)

Ann Arbor, MI, US

Ann Arbor, MI, US

• Provide instructional support for over 100 students through regular office hours and review sessions

Ingelheim Am Rhein, Rhineland-Palatinate, DE

• Assisted in frontline equipment troubleshooting in Drug Substance, Cell Culture, and Purification areas
• Evaluated different categories and models of mechanical pumps to replace current model and improve efficiency of centrifuge by 20% and reduce operational expenses by over $1000 per year
• Collaborated with manufacturing and engineering support groups to evaluate impact of centrifuge pump upgrade
• Designed software interface using Pi Historian and DeltaV to assist in drug harvest cycle to streamline monitoring process and collect key data metrics

Fort Wayne, Indiana, US

• Coded in Python and Arduino to design a semi-autonomous torsion tester for quick material testing on the production floor

Fort Wayne, Indiana, US

• Explored various coating modalities to aid in the activation of various prodrugs. These coating modalities included physical vapor deposition, electrodeposition, and thin wall drawn filled tube (DFT)®
• Conducted several corrosion studies to determine the effects of coating thickness on the corrosion rate of composite wire

Ann Arbor, MI, US

• Biomedical Manufacturing and Design Lab under Dr. Yihao Zheng and Professor Albert Shih
• Developed intensive testing and operational protocol for coronary atherectomy testing on over 50 phantom arteries
• Contributed to the publication of Grinding Wheel Motion and Force During Plaque Removal by Atherectomy in Angulated Coronary Artery, which was presented at the ASME conference in College Station, TX in June 2018
• Designed a CPAP mask attachment to improve accessibility for patients with ALS using SolidWorks and 3D printer
• Participated in the development of a new coronary angioplasty device by milling and lathing parts for prototype
• Used CNC milling and lathing techniques to make over 50 plaque mold and surrogates to use for testing

Doctor Of Philosophy - Phd, Molecular Engineering

Master Of Engineering - Meng, Biomedical/Medical Engineering

Bachelor Of Engineering - Be, Biomedical Engineering

Minor, Materials Science And Engineering

High School Diploma