I direct development of technology to evaluate efficacy of novel compounds targeting hematological disorders using bioluminescent techniques. I also develop federal funding proposals to support therapeutics research and prepare manuscripts. In this role, I am responsible for co-supervising research staff and plan research strategy with the Principal Investigator.Accomplishments:- Developed and execute a research project supported by an NIH SBIR Phase II award to use bioluminescent techniques to evaluate efficacy of novel compounds targeting metabolic and redox adaptive pathways in blood diseases and cancer. Using the results of this research, I prepare federal research proposals to develop a workflow to evaluate the efficacy of novel compounds targeting platelet-mediated inflammation.- Primary authorship of a manuscript describing the development of bioluminescence assay to test binding of novel compounds targeting biliverdin reductase.

• Prepared and coordinated grant proposals, reports, purchasing, patient recruitment, and training for two 5-year National Institutes of Health grants on heart valve disease and blood clotting totaling $7.5 million• Led 5 projects and cross-functional collaborations, supervising 16 students, fellows, and technicians• Developed a microfluidic platform to validate mathematical models of blood clots in cardiovascular devices and diseases• Developed bioluminescent techniques to test novel drugs targeting blood cell production

• Authored standard operating procedures (SOPs), designed and executed experiments to evaluate the biocompatibility of a novel polymer for prosthetic heart valves• Directed and collaborated on several projects validating blood function in computational fluid dynamics (CFD) and fluid structure interaction (FSI) simulations of ventricular assist devices, prosthetic heart valve prototypes, and extracorporeal membrane oxygenators, resulting in 12 publications and conference presentations• Coordinated research expenditures, authored administrative reports, and supervised collaborations with the University of Arizona, Politecnico di Milano, and Illinois Institute of Technology under a 5-year, $7.5 million NIH-funded grant

• Designed and executed 2 human subject studies to demonstrate superiority of cardiovascular implant design optimization over traditional antiplatelet therapy• Developed mathematical models in MATLAB to predict clotting risk under cardiovascular device-associated flow conditions• Authored and rigorously tested protocols to evaluate clotting risk in Class III cardiovascular implants, and incorporated into the laboratory’s standard operating procedures (SOPs)• Designed, constructed, and implemented a LabVIEW-powered syringe-pump for blood exposure to cardiovascular device flow conditions, resulting in 5 publications and conference publications

• Designed experiments and tested blood clotting activity in several Class III devices, such as prosthetic heart valves and ventricular assist devices, under flow conditions• Co-developed the Device Thrombogenicity Emulator method to assist cardiovascular device manufacturers with product optimization• Co-designed and constructed a viscometer and LabVIEW-based pressure-measurement system for cardiovascular device testing under flow conditions• Wrote and presented 10 scientific papers and conference presentations

• Reviewed and graded assignments, reports, and attendance for Biomedical Engineering Senior Design. • Provided feedback on Senior Design Projects

• Operated day-to-day operations including disclosure, license, and account management• Oversaw communnications with investors and START-UP NY• Negotiated license options and agreements with several entitites with regards to company intellectual property

• Performed statistical analyses for rat studies with blood coagulation products.• Advised researchers on results presentation methods.

• Conducted automotive parts scrap reduction audit and saved $21,466 in scrap costs.• Updated QS 9000 quality documents to TS 16949 format and made Customer Response System database functional.• Revised automotive Control Documents with respect to customer specifications.