Jay Blanchette Email & Phone Number

Innovative research professional with expertise in: delivery of bioactive agents, biomaterials, cell transplantation and regenerative medicineLeader who thrives in multidisciplinary team environments. Built and secured funding for a research team of 20+ personnel over 8 years. Research projects are conducted under GLP guidelines (FDA 21CFR58).Established reputation for integrity, safety and efficiency as a researcher responsible for generating SOPs for all lab work as well as obtaining and maintaining regulatory approval for biosafety (BSL-2), recombinant DNA (IRB) and animal studies (IACUC)Research generated has led to 25 peer-reviewed publications which have been cited in excess of 2000 times. International recognition for research efforts related to oral chemotherapeutic delivery systemsPI on grant from NIH focused on utilizing living delivery systems to promote local vascularization.Scientific reviewer for NIH and DoDConfident, well-spoken researcher with extensive presentation experience and excellent communication and conflict resolution skillsSKILLSPolymer synthesis/characterization (nanoparticles, microparticles and macroscale hydrogels); environmentally-responsive swelling behavior; conjugation of cell-instructive moieties to scaffold materialsDrug loading/release studies; tumor models and in vitro analysis of drug delivery systems Animal surgery (survival and tissue harvesting)Cell expansion (including human stem cells, primary tissue, cell encapsulation and 3D culture)Cell signaling and molecular biology (subcellular fractionation, western blotting, IP westerns, RT-PCR, ELISA, FACS, apoptosis/necrosis) Recombinant DNA with vector design and generation (adenovirus)Histology and IHC (including laser capture microdissection)Role of oxygen tension on cell phenotype; designed fluorescent marker to track HIF activity at a cellular level; ischemic preconditioning protocols Islet biology; islet isolation, dissociation/reaggregation

Listed skills include Biomaterials, Molecular Biology, Cell Culture, Drug Delivery, and 14 others.