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Research and discovery are my passions. I look forward to elucidating each unknown and to working with my colleagues to advance early phase drugs to human trials. My most recent position as associate director of biophysics at Faze Medicines involved utilizing biophysical techniques to elaborate lead programs in neurology and oncology. In addition, I developed plans for new drug discovery programs.Prior to Faze I worked in immonology as a translational scientist at Janssen Pharmaceuticals and in several different drug discovery and development roles at Momenta Pharmaceuticals. Throughout my career I have always enjoyed the problem solving aspects of research and the process and planning that leads to successful research programs..I currently lead a program at Momenta with a group of researchers looking to optimize the characteristics of glycoprotein therapeutics through in vitro and in vivo manipulation.While I enjoy managing programs, I also relish laboratory work and am well-versed in current techniques used to study biomolecular interactions (Biacore), CRISPR genome modification, gene expression analysis (both wet-lab and data analysis workflows).
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Associate Director Of Discovery BiologyFrontier Medicines Mar 2023 - PresentSouth San Francisco, Ca, UsDiscovering covalent small molecules to drug the undrugable. Employing biochemical and biophysical techniques for hit finding, hit triage, lead discovery and drug candidate nomination. -
Associate Director, BiophysicsFaze Medicines Jan 2022 - Nov 2022Cambridge, Massachusetts, UsAssociate director of biophysics in a drug discovery team researching small molecules that perturb the functions of biomolecular condensates relevant to disease biology. Managed CROs and research plans for biomolecular interactions. Developed drug discovery plans for new targets in oncology. -
Principal ScientistThe Janssen Pharmaceutical Companies Of Johnson & Johnson Oct 2020 - Dec 2021Raritan, New Jersey, UsWorking on translational science in the immunology therapeutic area for autoantibody-driven diseases. Identifying biomarkers and developing assays to understand aspects of disease and treatment. -
Principal ScientistMomenta Pharmaceuticals Dec 2018 - Oct 2020Cambridge, Massachusetts, Us -
Senior ScientistMomenta Pharmaceuticals Nov 2006 - Oct 2020Cambridge, Massachusetts, UsDisease BiologyUsing surface plasmon resonance to evaluate protein/polysaccharide interactions, antibody affinity and immunogenicity.Gene expression studies using RT-PCR and associated analysis techniques -
Research Associate IiBroad Institute Of Mit And Harvard Dec 2004 - Nov 2006Cambridge, Ma, UsDesign and conduct secondary biochemical assays to confirm small molecule binding to protein targets using primarily the Biacore S51 surface plasmon resonance instrument. Other types of assays include human serum albumin binding, equilibrium dissociation constant (KD) measurement for small molecules binding to proteins. -
Applications Engineer IiEntegris Mar 2001 - Apr 2004Billerica, Ma, UsSupported Photochemical Filtration and Wet Etch and Cleans Filtration business areas. Designed testing for new products, solved application related problems with existing products and provided technical data on the effacacy of filtration and ozone contacting products to promote their use in new areas. -
InternMillennium Pharmaceuticals Jun 1999 - Mar 2001Cambridge, Ma, UsDeveloped test methods for ensuring the accuracy and repeatability of automated pipettors used in high throughput screening (HTS). Assisted in building and maintaining robotic systems. -
InternCharles Stark Draper Laboratory Jun 2000 - Dec 2000Cambridge, Ma, UsAs a member of the Chem/Bio group I worked with flexural plate wave (FPW) biological and chemical sensors. I tested the efficacy of polymer coating and protein binding to the sensors gold plated surface.
Jay Duffner Skills
Jay Duffner Education Details
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Tufts UniversityChemical Engineering -
Northeastern UniversityPharmaceutical Biotechnology -
Boston UniversityManagement
Frequently Asked Questions about Jay Duffner
What company does Jay Duffner work for?
Jay Duffner works for Frontier Medicines
What is Jay Duffner's role at the current company?
Jay Duffner's current role is Associate Director of Discovery Biology.
What is Jay Duffner's email address?
Jay Duffner's email address is jd****@****rma.com
What is Jay Duffner's direct phone number?
Jay Duffner's direct phone number is +161728*****
What schools did Jay Duffner attend?
Jay Duffner attended Tufts University, Northeastern University, Boston University.
What are some of Jay Duffner's interests?
Jay Duffner has interest in Hiking, Soccer, Science History, Cycling.
What skills is Jay Duffner known for?
Jay Duffner has skills like Biotechnology, Assay Development, Protein Chemistry, Elisa, Molecular Biology, Cell, Qpcr, Drug Discovery, High Throughput Screening, Rt Pcr, R, Statistics.
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