Jayon Lihm Email & Phone Number

Leading computational efforts for the development of personalized neoantigen-based cancer vaccine

New York City Metropolitan Area

Greenbaum's lab (Computational Oncology, Department of Epidemiology and Biostatistics)Long story short: Focused on identifying immunogenic neoantigens in various types of tumors== On going ==- Immunogenicity of frameshift peptides in MSI-high endometrial cancer patients- Tumor-rejection neoantigen prediction in mouse models (Kras/p53 mutant lung cancer)- Co-evolution of tumor and host's immune landscape from rapid autopsy samples- Toxicity study for Ipilimumab + Nivolumab in renal cell carcinoma patients- Neoadjuvant therapy clinical trial in muscle invasive bladder cancer- Evolution of somatic mutations in immune-deficient and competent mice== Wrapped up ==- Oxford nanopore long reads pipeline construction- PDAC mRNA personalized neoantigen vaccine clinical trial: computational lead (published)- PDAC long term and short term survivors (published)- Neoantigen profiles in lung cancer patients with acquired resistance to immunotherapy (published)- Impact of chemotherapy on neoantigen landscape of PDAC primary tumors==List of clinical trials==PDAC vaccine, muscle-invasive bladder cancer neoadjuvant therapy, MSI-high endometrial cancer patients for ICB

Lecture in Department of Information System and Business Analytics @ Zarb Business School- R programming (BAN266)- Advanced Quantitative Analysis for Managers (BAN203)- Introduction to Business Statistics (BAN001)

Greenbaum's lab @ Tisch Cancer Institute- PDAC neoantigen profile changes between pre and post chemotherapy- Hypermutation in pancreatic cancer

- Modeled the risk of inherited genetic variants on psychiatric disorders with WGS (**Publication: Ryan and Lihm et al, 2018, https://www.nature.com/articles/s41380-018-0087-4)- Profiled the epigenetic changes in mouse brain regions after fear-conditioning using ATAC-seq (https://github.com/jlihm-seq/atac-seq, ** Oral presentation: Genome Informatics meeting, 2017)- Developed a SNP detection algorithm in highly repeated regions in human genome (https://github.com/jlihm-seq/CPC)- Completed ”Bioinformatics for Cancer Genomics course” at Cold Spring Harbor Laboratory (2018)- Characterized genetic landscape of breast cancer organoids from clinical samples using 10X sequencing platform

Cold Spring Harbor, Ny

- Developed a data-driven SNP calling algorithm using mixture models (PhD Thesis available at https://ir.stonybrook.edu/xmlui/handle/11401/76128)- Profiled exome CNV regions of more than 1000 quads in Simons Simplex Collection for autism- Constructed data processing pipeline to process raw sequence data (fastq files) to BAM, pileup files, read-depth count files for variant calling and analysis. Pipeline includes the usage of common bioinformatics tools such as BWA, PICARD, GATK, SAMTOOLS.- Data generation to detect copy number variation (CNV) regions for whole exome sequencing data of autism quad families (Simons Simplex Collectiom for autism)- Quality control analysis for family sequencing data

Stony Brook, Ny

Lectured AMS315 Data Analysis class in Department of Applied Mathematics and Statistics

Manhattan, Ny

- Detected common deletion and duplication regions using read-depth approach as part of Structural Variation group in the 1000 genomes project, Phase 1 (publication: The 1000 genomes project consortium, 2012)- Prioritized and selected SNP sites for validation from whole exome collection in ARRA autism study (publication: Neale et al, 2012)- Performance analysis for annotation tool development: AnnTools (publication: Makarov et al, 2012)

Stony Brook, Ny

AMS510 Analytical Methods for Applied Mathematics and Statistics (Fall, 2009)AMS110 Probability & Statistics for the Life Sciences (Spring, 2010)AMS571 Mathematical Statistics (Fall, 2010)

Discrete Mathematics and Programming, Numerical Analysis, Differential Equations, Calculus I,Mathematical Science and Information

Seoul, South Korea

- Credit risk management- Developed Behavior Scoringcard system for Samsung Life Insurance; collaboration with Fair Isaac, CA.- Proposal documentation for multiple types of credit scoring system development- Coordinated 'Credit Fair 2008', October, 2008 in Seoul, S. Korea.

Doctor Of Philosophy (Ph.D.), Statistics

Ms, Mathematics

Activities and Societies: Teaching Assistant

Bs, Mathematics, Economics

Activities and Societies: ESAOS (Ewha Symphonious Amateur Orchestral Sounds)

Computer Science