Jay Bhatt Email & Phone Number

Johnson City, Tn, Us

South San Francisco, California, Us

Tarrytown, New York, Us

Tarrytown, New York, Us

Tarrytown, New York, Us

• Contribute to IND and BLA projects to move the drugs through pipeline• Provide Complete analytical characterization of lead antibody candidates• Study charge variants, low and high molecular weight species• Write reports for the study findings, IND and BLA sections• Provide cross-functional support• Collaborate with other groups by leveraging LC-MS based solutions• Develop Method validation and qualification assay in line with ICH and FDA guidelines• Study higher order protein structure via HDX and protein footprinting• Troubleshoot and maintenance of Waters HDX system coupled with LEAP automation platform• Routine maintenance of Analytical Instruments: Waters Alliance HPLC, UPLC, nano ACQUITY, HDX, Thermo - QExactive Plus, Waters XevoG2F, Shimadzu MALDI

Tarrytown, New York, Us

• Generate DNA constructs in support of the company's Veloclmmune human antibody pipeline.• DNA constructs used to support mAb screening, immunization of VelocImmune Mouse and various internal research programs. Manipulate constructs through subcloning and mutagenesis.• Perform transfections of constructs produced into cells to assess expression levels. Determine and analyze variable region sequences of mAbs produced.• Application of molecular biology techniques including plasmid construction, DNA manipulations, DNA and RNA isolation, purification, PCR, SDS-PAGE, Western Blot, primer design, sequence analysis and tissue culture skills.• Software and Database skills: Sequencher, Macvector, IMGT/V-QUEST, SwissProt, BLAST.• Volunteer to assist in process improvement, weekly presentations, laboratory supply ordering and maintenance in a fast paced work environment.

Darmstadt, De

Assist to build up the IgGs libraries within deadline. Acquire the skills of DNA miniprep, DNA maxi prep, Molecular Cloning, Sub cloning, DNA ligation, Transformation, Transfection, Agarose gel electrophoresis, during the process. Trouble shooting and data analysis of recombinants.Finish the construction of six plasmid vectors within project time line.Responsible for isolation, purification, amplification of DNA after plasmid constructs.Responsible for Transformation and transfection of DNA constructs to E.Coli Perform PCR,DNA miniprep- maxiprepOperate instruments like Nanodrop, Genetix-Qpix2 colony picker, Matrix Platemate liquid handler, Eddy-jet Spiral plater etc.Well organized, detail documentation skills as prepare and submit weekly reports, presentations and write patent safes.Commended by project manager for enthusiasm and sharp learning skills.Other Analytical Techniques Learned: SDS-PAGE, ELISA, Protein-A purification, Electroporation.

Boston, Ma, Us

Design, test and develop the protocol for Protein Isolation. Ensure the delivery of analytical results after Protein Purification and Characterization studies for post translational modifications of proteins

Responsible to carry out introduction of magnetic particles to WBC to develop a novel therapy against human pancreatic cancer.Application of Electroporation, SRB assay, RP-HPLC, FACS to meet the project requirement.

M.S, Molecular Analytical Biotechnology

Bachelor'S Degree, Pharmacy

Diploma, Pharmacy