Jay (Saurav) Chandra, Ph.D. Email & Phone Number

Greater Boston, Usa

• Scientific Lead on Global Clinical trials• Subject Matter Expert on a multitude of Musculoskeletal disorders, rare diseases etc. • Medical and Scientific liaison to clients and Research organizations - Provide Scientific strategy• Business Development/Marketing: Lead and present at Bid defenses• Accountable for project specific Imaging parameters• Responsible for Study documentation (Charters, Reviewer training, eCRF, Imaging guidelines etc)• Lead/Consult on training… Show more • Scientific Lead on Global Clinical trials• Subject Matter Expert on a multitude of Musculoskeletal disorders, rare diseases etc. • Medical and Scientific liaison to clients and Research organizations - Provide Scientific strategy• Business Development/Marketing: Lead and present at Bid defenses• Accountable for project specific Imaging parameters• Responsible for Study documentation (Charters, Reviewer training, eCRF, Imaging guidelines etc)• Lead/Consult on training of independent reviewers, evaluate assessment results as needed• Lead on various Imaging Application development initiatives• Collaborate with key opinion leaders and criteria authors to refine assessment criteria Show less

Greater Philadelphia Area

• Strategic Leadership + Scientific Project Management • Manage Global Clinical trials - Phases 1-3• Strategic decision making and scientific input during Study Design phase• Oncology, Musculoskeletal disorders, Alzheimer’s/Parkinson’s, CNS/Neuroscience, Ophthalmology, Medical devices, Pulmonary Disorders, Stem Cell Research, Diabetes, etc.• Facilitate communication between global, cross functional teams• Primary client contact – communicate client needs and concerns to… Show more • Strategic Leadership + Scientific Project Management • Manage Global Clinical trials - Phases 1-3• Strategic decision making and scientific input during Study Design phase• Oncology, Musculoskeletal disorders, Alzheimer’s/Parkinson’s, CNS/Neuroscience, Ophthalmology, Medical devices, Pulmonary Disorders, Stem Cell Research, Diabetes, etc.• Facilitate communication between global, cross functional teams• Primary client contact – communicate client needs and concerns to CROs and internal teams• Finance - Create & negotiate budgets ($ Million+), change orders and monitor other financial transactions• Oversight of processes like eCRF development, data acquisition, analysis and review• Work with Scientific & Medical Affairs group to author Charters, Manuals, SOWs, eCRFs, SOPs, etc.• Develop Reader training material, conduct reader training, familiar with assessment criteria (Recist 1.1 etc.)• Provide reports, analysis of trends, queries and other issues, safety and efficacy, quality checks of clinical data • Conduct detailed review and analyses of clinical data. • Liaise between CMOs, CSOs, VPs, KOLs, PIs, Radiologists, Scientists, and Icon’s internal teams. • Prepare and present at global client meetings, Investigator, Kick-off meetings, etc.• Conduct training sessions for Readers for Independent review committees• Activate sites, startup procedures, maintain smooth operation of trials Show less

San Antonio, Tx

• Developed Advanced MR Imaging methodologies for various projects in Neuroscience, Ophthalmology, Cardiovascular disorders, etc. • Advanced Imaging techniques included Diffusion Tensor Imaging, Arterial Spin Labeling, MR Angiography, OCT etc.• Project Leader responsible for developing and carrying scientific projects from inception to publicationo Study design, implementation and execution/monitoring of experimentso Image optimization, data analysis, statistics, data… Show more • Developed Advanced MR Imaging methodologies for various projects in Neuroscience, Ophthalmology, Cardiovascular disorders, etc. • Advanced Imaging techniques included Diffusion Tensor Imaging, Arterial Spin Labeling, MR Angiography, OCT etc.• Project Leader responsible for developing and carrying scientific projects from inception to publicationo Study design, implementation and execution/monitoring of experimentso Image optimization, data analysis, statistics, data interpretation etc.o Identification of biomarkers and endpoints.o Publication in peer reviewed journals• Leadership responsibilities include:o Act as Liaison between clinicians/collaborators and lab staffo Manage team members, delegate tasks, check for quality, evaluate work etc.o Mentor and train research associates, staff, trainees and students• Multiple first author publications in renowned journals• Excellent written, oral, interpersonal and presentation skills Show less

Cambridge, Ma

• Preclinical Imaging and Drug Discovery - Various Disease Areas• Lead Scientist on multiple projects in collaboration with areas like Oncology, Musculoskeletal Disorders, Neuroscience, Cardiovascular, Ophthalmology, etc• Tumor detection, Biomarkers identification, Determining key treatment time points, Target Validation for various studies• Established Study Design, Planning, Image Optimization, Setup and Execution of experiments• Planned Efficacy studies based on PK/PD… Show more • Preclinical Imaging and Drug Discovery - Various Disease Areas• Lead Scientist on multiple projects in collaboration with areas like Oncology, Musculoskeletal Disorders, Neuroscience, Cardiovascular, Ophthalmology, etc• Tumor detection, Biomarkers identification, Determining key treatment time points, Target Validation for various studies• Established Study Design, Planning, Image Optimization, Setup and Execution of experiments• Planned Efficacy studies based on PK/PD profiles of various compounds• Developed Image Processing techniques, Statistical Analysis methods• Presented results to collaborators, gave talks at board meetings, worked extensively with teams• Expertise in animal handling, dosing (sub cutaneous, tail vein etc), anesthesia procedures, euthanasia• Designed MRI compatible Equipment Show less

• Developed Diffusion Tensor MRI techniques to detect retinal degeneration in diabetic mice • Statistically characterized progressive pathological stages of Diabetic Retinopathy• Discovered capability of hematopoietic stem cells to repair the RPE layer in mice using DT-MRI• Investigated iron deposits in human brains with Parkinson’s and Alzheimer’s disease using MRI• Mapped metal compounds in brain using synchrotron micro-focus x-ray fluorescence (µXRF) spectroscopy• Tracked… Show more • Developed Diffusion Tensor MRI techniques to detect retinal degeneration in diabetic mice • Statistically characterized progressive pathological stages of Diabetic Retinopathy• Discovered capability of hematopoietic stem cells to repair the RPE layer in mice using DT-MRI• Investigated iron deposits in human brains with Parkinson’s and Alzheimer’s disease using MRI• Mapped metal compounds in brain using synchrotron micro-focus x-ray fluorescence (µXRF) spectroscopy• Tracked the migration of Monocrystalline Iron Oxide (MION) labeled Endothelial Progenitor Cells (EPCs) towards damage sites in mice with Choroidal Neo-Vascularization (CNV).• Co-invented an Integrated Digital Manometer prototype for Lumbar Puncture procedures. (Won Department award for best design, nominated at National level) Show less

• Employed Functional MRI techniques to investigate effects of alcohol on the CNS and behavioral task performance • Designed audio-visual paradigms for subjects to acquire fMRI data• Investigated emotional responses to commercials using fMRI (in collaboration with Dept. of Journalism)

Phd, Biomedical Engineering

- Advanced MRI Applications in Ophthalmology, Neuroscience, Stem Cell Therapy - Employed Diffusion Tensor MRI to detect Retinal.

Ms, Biomedical Engineering

Medical Imaging - MRI, fMRI, CT, X-Ray, PET, Radiation Physics/Oncology Other interests included: MR Spectroscopy, EEG, SPECT etc

Bachelor Of Engineering, Instrumentation Engineering

Major in Biomedical Instrumentation