Jd Alvarez, Md, Phd Email & Phone Number

Basking Ridge, Nj, Us

Lead the entire Companion Diagnostics department within Precision Medicine.

Basking Ridge, Nj, Us

Lead an international team responsible for developing and registering companion diagnostics globally for Enhertu and two other late stage ADC programs.

Brentford, Middlesex, Gb

Set strategic direction for and led a team responsible for developing and delivering companion diagnostics across all therapeutic areas, including vaccines, within R&D.• Delivered FDA approval of a companion diagnostic assay that was required for FDA approval of dostarlimab, an anti-PD1 antibody for the treatment of endometrial cancer and pan-tumor indications.• Established a digital pathology team to develop novel companion diagnostics to enable new biomarker discovery and product approvals.

Raritan, New Jersey, Us

Led a 50-person organization that was responsible for the development and implementation of biomarker assays required for Oncology clinical trial biomarker strategies.• Consolidated translational research laboratories within Oncology to increase collaboration between laboratory functions leading to alignment with department goals.• Reorganized translational research clinical operations team to provide clear development opportunities and to align with company priorities.• Developed and led tissue image analysis strategy to support Oncology R&D.

Raritan, New Jersey, Us

Established and led a new department focused on development of companion and complementary diagnostics required for registration of new oncology pharmaceutical assets. • Recruited and trained laboratory staff and companion diagnostic scientists to develop and deliver diagnostics.• Drove companion diagnostic development for early and registration stage clinical programs including selection of diagnostic partners, communication with regulatory authorities, development of IDEs, auditing laboratories and evaluating performance data.• Delivered FDA approval of a companion diagnostic assay that supported registration of erdafitinib, an FGFR inhibitor that had breakthrough therapy designation in metastatic bladder cancer.

Raritan, New Jersey, Us

Raritan, New Jersey, Us

Gained increasing responsibility leading labs, teams and projects focused on driving oncology compound discovery and clinical development. Took on additional development opportunities to learn more about drug development.• Developed and executed biomarker and translational medicine strategies for oncology compounds (small and large molecules) to inform decisions on early clinical development of compounds.• Managed oncology biomarker core laboratories and staff leading to biomarker discovery and enabling clinical development of both small and large molecules.• Drove new technology development including digital pathology and multispectral imaging to support disease characterization and indication selection.• Acted as medical monitor for first in human trials involving immuno-oncology compounds. Activities included protocol development, investigator management, adverse event evaluation and making decisions on dose escalation.• Led Breast Cancer Strategy Group responsible for defining internal strategy, evaluating external business opportunities, and recommending clinical development of compounds within breast cancer indications.

Raritan, New Jersey, Us

Raritan, New Jersey, Us

Designed, implemented and interpreted molecular pathology assays in support of oncology pre-clinical work and clinical trials

Developed and implemented biomarker strategies in support of oncology discovery and compound development programs. Established a histopathology and imaging core laboratory.

Philadelphia, Pa, Us

Conducted independent, external grant funded research on circadian rhythms. Provided clinical service for the Department of Pathology within the School of Medicine.

Assisted in establishing a new basic research department. Trained and supervised new scientists and technicians. Conducted research in support of immunology discovery programs.

M.D., Medicine

Fellow, Molecular Genetic Pathology

Resident, Anatomic And Molecular Pathology

Ph.D., Molecular And Cell Biology

B.S., Molecular Cell Biology