Jeff Upton Email & Phone Number

San Francisco, CA, US

Cary, North Carolina, US

Drive the adoption of data analytics and visualization using JMP to help companies make better, data-driven decisions

Cary, North Carolina, US

Switzerland 🇨🇭, CH

• Drive development of new nucleic acid purification protocols on Roche's IVD MagNAPure 24 system

Switzerland 🇨🇭, CH

• Achieved technical milestones related to feasibility research and development of a new IVD PCR system
• Transferred prototype PCR instruments from internal developers during a site visit to Rotkreuz, Switzerland
• Developed a quality control method to determine the eligibility for release of new LightCycler (LC) 1536 instruments
• Transferred LC1536 QC method to the manufacturing team during a visit to Roche’s Penzberg, Germany site
• Built/maintained a performance qualification (PQ) protocol for Roche's workhorse LC480 qPCR systems and led a team to complete testing on a semiannual basis
• Adapted to learn FLOW workflow automation system and MagNAPure 24 sample preparation system on truncated time tables for multiple verification and validation (V&V) efforts

Switzerland 🇨🇭, CH

• Developed and debugged test cases to uncover issues and improve testing efficiency prior to validation
• Studied project documentation to ensure complete testing of each G&O analysis package
• Performed installation, operation and performance qualifications (IOQ/PQ) for cobas 4800 systems, including software, hardware and networking used in validation efforts
• Relevant training: qPCR, GLP, GDP, IQ/OQ/PQ, HPQC, V&V

La Jolla, CA, US

• Participated on teams to develop and validate systems and assays - Developed a small-volume assay to predict culture performance in pilot scale cultures - Tested a series of methods aimed at minimizing contamination in.
• Configured and maintained over 20 PLCs, 2 site SCADA systems, LabVIEW packages, and OPC network
• Assisted in demo facility startup: equipment ordering, lab setup, SOP development, and staff training
• Supported pilot plant operations via sample collection, data collection and management, design and execution of experiments, and process control and support
• Relevant training: pilot plant safety; LabVIEW (Core 1 and 2); JMP (statistics & DOE); Wonderware SCADA; SCADAPack; OSHA electrical safety; CPR, AED, and first aid

South San Francisco, California, US

• Support transition of clinical trial information from TrialWorks to Siebel System

South San Francisco, California, US

• Designed key process indicator monitoring tools capable of compiling and analyzing real-time/historical data from the plant OSIsoft PI system
• Utilized process flow diagrams (PFDs), piping and instrumentation diagrams (P&IDs) and system turnover packages to familiarize myself with each support system
• Coordinated compressed air system study with an outside equipment contractor - Results indicated potential savings of $140,000/year with implementation of a VFD compressor - Independent mass balance analysis indicated.
• Relevant training: GMP, clean room, P&IDs, chemical and biological safety

Davis, California, US

• Worked with Dr. McDonald's team towards the genetic engineering and optimization of switchgrass and tobacco plants for the production of endoglucanase and anthrax decoy protein
• Established protocols, ran experiments, and analyzed data with graduate student mentors - Tested media and environmental conditions to optimize bacterial growth - Infiltrated plant cells using agrobacteria to transfer.

Master'S Degree, Engineering Management And Leadership

B.S., Biochemical Engineering