Jacob E John Email & Phone Number

It may be enquired and proposed, whether the "country" pharma/biotech drug manufacturers associations in each country, will set up Study Groups for rare diseases, medicines, vaccines, diagnostics and medical devices, on a long term basis.11 Univ Prof. physicians (medicine) 7, and scientists 4. 11 Pharma, Biotech, physicians 7, and scientists 4. 22 members.Annual Conferences. Annual Perspectives. Annual Reviews. It may be enquired and proposed, whether the "country" pharma/biotech drug manufacturers associations in each country, will set up Study Groups for tropical diseases, veterinary diseases, medicines, vaccines, diagnostics and medical devices, on a long term basis.11 Univ Prof. physicians (medicine) 5, scientists 4, and veterinarians 2. 11 Pharma, Biotech, physicians 5, scientists 4, and veterinarians 2. 22 members.Annual Conferences. Annual Perspectives. Annual Reviews.Study Groups11 members nominated by Country Medical Associations 9, University Medical Schools 1, WHO 1. 11 members nominated by Country Drug Manufacturers Associations.Formation and Nominations, every two yearsGender EqualTwo year term Open Access Articles, Medical JournalsNine to eleven meetings each year Meetings, one weekBoard & Lodging, 4* HotelCompensation, Univ ProfessorPermanent Secretariat at ........, 2 physicians, 2 scientists, 2 executive assistants, 2 managers.

Asia Africa South America Central America Oceania

Infectious Diseases Society of Asia. Conferences, Study Groups, Courses and Workshops, and Journals.Infectious Diseases Society of Africa. Conferences, Study Groups, Courses and Workshops, and Journals.Infectious Diseases Society of South & Central America. Conferences, Study Groups, Courses and Workshops, and Journals.Infectious Diseases Society of Oceania. Conferences, Study Groups, Courses and Workshops, and Journals.Membership-based organizations, 11+ co-chairpersons, gender equal, Science and Medicine. International, annual conferences on tropical diseases, veterinary diseases and infectious diseases.Publications of conference proceedings, by Infectious Diseases Society.Major tropical diseases, above 22+Minor tropical diseases, above 111+Veterinary infectious diseases, above 55+

Thank you for your support, Universities, Scientific and Medical Societies, and Schools of EconomicsJacob E John, Medicines for rare diseases; support through tax-incentives, Drug Disc Today, 2011, Dec, 16 (23/24), 999-1000. ..... with FDA, EMA, DDC above 5252 rare diseases.including rare types of cancer, cardiac conditions, thoracic conditions, respiratory conditions, ophthalmic conditions, vascular conditions, epithelial conditions, skin conditions, muscle-skeletal conditions, digestive conditions, infections, neurological conditions, inflammation, immunological conditions, endocrine conditions, connective tissue conditions, exocrine conditions, metabolic conditions, ear conditions (hearing, balance), dental conditionsMedicines, vaccines, diagnostics and medical devicesDedication; Declaration of Geneva for Medicine. Dedication; Mothers' Day, Fathers' Day & Children's Day .A key for ~ 10,000+ jobs in Europe, USA, Canada, Japan, ANZ, and Asia, Africa, and South & Central AmericaEmployee Ownership of Organisation = 15%Cost to the economy = + 0.5% for energy. about 0.05% of GDPAbout 25+ billion US$ p. a., across North America, Europe, ANZ, and Asia, Africa, and South & Central AmericaThis covers research and development ...... and production and distributionCompliant with SDG MDG ILO WTO FDA EMA ICH DDC IP Liberty Trust HealthCare Equality Justice Law Sovereignty, Fraternity of People and Nations, Goodwill, Peace, not-for-loss, CSR multi-lateral.NOT Included: MP Innovation, IMI, Venture Captl.

For Pharmaceutical Companies And Biotechnology Companies

Medicines research for rare diseases, support through tax-incentives.Research and development, production and distribution of medicines, vaccines, diagnostics and medical devices for rare diseases.Jacob E John, Medicines for rare diseases; support through tax-incentives, Drug Discovery Today, 2011, 16 (23/24), 999-1000. ..... with FDA, EMA, DDC.These two areas are linked for large Pharma and Biotech Co's (MNC)Medicines research for tropical diseases, support through tax-incentives.Research and development, production and distribution of medicines, vaccines, diagnostics and medical devices for tropical diseases and veterinary diseases.Jacob E John, Medicines for tropical diseases; support through tax-incentives, Drug Discovery Today, 2010 2011, 16 (3/4), 91–92. .... with FDA, EMA, DDC.in Asia, Africa, South & Central America, Pacific Ocean regions.This area "Tropical Diseases"​ is essential for Pharma and Biotech Co's in Asia, Africa, South & Central America and Oceania.Compliant with SDG MDG ILO WTO FDA EMA ICH DDC IP Liberty Trust HealthCare Equality Justice Law Sovereignty, Fraternity of People and Nations, Goodwill, Peace not-for-loss CSR multi-lateral.For Pharmaceutical Companies and Biotechnology Companies, only.In-house pre-clinical Research and clinical Development.Employee Ownership of Organisation = 15%Mutually beneficial arrangements with Universities, Academia and public-funded research organizations will cover pre-clinical research, clinical development, and clinical and medical use.Just Thinking about Quality.Not included: London Declaration on NTDs 2012. United to Combat NTDs. Kigali Declaration on NTDs 2022.Adverse effects of medicines. Drug-resistance (AMR). Deficient in pre-clinical and clinical R&D. Disease areas, limited range.Vaccines, Diagnostics, Medical Devices not mentioned.Limited Participation. Not Inclusive.Developmental Economics ?Scientific, Medical Literature ?Location ? Conferences ?

Natural products, Biotechnology and Drug DiscoveryJacob E John, Natural products-based drug discovery: some bottlenecks and considerations, 2009, Current Science, 25th March, vol 96(6), 753-754.Jacob E John, Natural products as lead-structures; a role for biotechnology, 2010, Drug Discovery Today, Volume 15, Issues 11-12, June 2010, Pages 409-410.

Thank you for support, Universities, Scientific and Medical Societies, and Schools of Economics.Developing the scope and success for tropical diseases research, in tandem with several other research areas, e.g. cancer, natural products, (published in 2009, 2010).Drug Discovery Research, Tropical Diseases.Malaria Leishmaniasis Chagas Filariasis TB viral infections fungal infections HAT (sleeping sickness).Biology Lead discovery Project management.focused libraries, natural product-like compounds, cell-based screening.JE John, Medicines for tropical diseases; support through tax-incentives, Drug Discovery Today, 2010 2011, volume 16 (3/4), 91–92. with FDA EMA DDCDedication; Declaration of Geneva for MedicineMedicines, vaccines, diagnostics and medical devices.all tropical diseases Approx ~ 8,000+ jobs in Asia Africa, South & Central America, Europe (Greece Cyprus Malta Spain Portugal Italy) North America (Hawaii Honolulu), Oceania ANZ European colonies (Caribbean Atlantic Pacific Indian Ocean)Cost to economy = + 0.5% for energy. about 0.05% of GDPAbout 5+ billion US$ p.a. Asia Africa, South & Central America ......... Europe, North AmericaCompliant with SDG MDG ILO WTO FDA ICH EMA DDC IP Liberty Trust HealthCare Equality Justice Law Sovereignty Fraternity of Nations Goodwill Peace no loss CSRJE John, Tropical diseases research and anti-fungal research linked with cancer research, Current Science, 2009, 97(12), 1704. with FDA EMA DDCJE John, Anti-infective agents; natural products based drug discovery, Current Science, 2007, 93(10), 1336-1337. (cf co-enzymes, nucleotides).JE John, Natural products-based drugs and membrane permeability, A hypothesis, Chem Biol Drug Design, 2009, 73, 367-368.JE John, Cytotoxic natural products and their pharmacological mode of action; a hypothesis on their complexity and spectrum of activity. Current Enzyme Inhibition, 2012, 8 (1), 101-103.Employee Ownership of Organisation = 15%

Thank you for your support, Universities, Scientific and Medical Societies, and Schools of Economics.R&D for Tropical Diseases, medicines, diagnostics and vaccines, public funding, above 5 countries. "Network"​, driven by science. more than 22+ indications. R&D for Tropical Diseases, Drug Discovery, public funding, above 5 countries. Natural products research. "Network"​, driven by science and patents. "Collaborations with pharma and biotech companies ...with tax-incentives ... FDA EMA."​in Asia, Africa, and South & Central America.Jacob E John, Natural products-based drug discovery: some bottlenecks and considerations, 2009, Current Science, 25th March, vol 96(6), 753-754.JE John, Pharma Research for Tropical Diseases, Current Science, 2006, 91(9), 1127, Bangalore (Indian Academy of Sciences), India. Dedication; Declaration of Geneva for Medicine.A key for ~ 5000 jobs in India, Pakistan, Turkey, China, S Africa, Brazil, Argentina, Mexico, ......... "Network", driven by science and unmet medical needs. Cost to the economy = + 1% or 2% for medicines, vaccines, diagnostics.Compliant with MDG SDG ILO WTO IP Liberty Trust HealthCare Equality Justice Law Sovereignty, Fraternity of People and Nations, Goodwill, Peace not-for-loss, CSR multi-lateral. JE John, Anti-Infective Agents: Spectrum and Selectivity, Current Science, 2007, 92(2), 159, Bangalore (Indian Academy of Sciences), India.

JE John, Medicines for tropical diseases; support through tax-incentives, Drug Discovery Today, 2011 (2010), volume 16 (3/4), 91–92. ..... with FDA and EMA.JE John, Tropical diseases research and anti-fungal research linked with cancer research, Current Science, 2009, 25th Dec, 97(12), 1704. with FDA and EMA.JE John, Pharma Research for Tropical Diseases, Current Science, 2006, 91(9), 1127, 2006, Bangalore (Indian Academy of Sciences), India.Peace is always welcomeWhom It May ConcernInformationOrganizations that are NOT included in these frameworks for tropical diseases research and development for medicines, vaccines and diagnostics.CRO, WEF (Bilderberg), BMGF & similar foundations, WB, IMF, Wellcome Trust, WHO-TDR, ANDI, ..NDI, UNOPS, WHO-NTD, G7, MMV, TB Alliance, DNDi, FIND, AREAS, GAVI, IAVI, MM4TB, NM4TB, iM4TB, PATH, OSDD (CSIR), GHIT, Global Fund GFATM, unitaid, UNAIDS, DFID, USAID, UKAID, "Country-AID"​, CHAI, EU-EC, NIH, Global Research Council, Universities, "StopTb"​, MSF, WRAIR, IDRI, GAFFI, MPP, WWARN, IDDO, Sabin, EVI, IVI, VIDO, The Union TB, FDA-Vouchers, KNCVTBC, DDTD, Malaria Consortium, MalariaNoMore, EDCTP, EastWestScienc, eghstrat, csgid, thesgc, TBVI, Broad Inst, FNDR, MP-Innovation, EVT, ASTX, Venture Captl, GARDP, GHDDI (Beijing), ospfound.not included: London Declaration on NTDs 2012.United to Combat NTDs.Kigali Declaration on NTDs 2022.Adverse effects of medicines. Drug resistance (AMR). Deficient in pre-clinical and clinical R&D deficient. Disease areas, limited range.Vaccines, Diagnostics, Medical Devices not mentioned.Limited Participation. Not Inclusive.Developmental Economics ?Scientific, Medical Literature ?Location ? Conferences ?

Intellectual Property Intellectual Property protection, for patents, trademarks, geographical indications and copyrights, introduced in Asia, Africa and South America. In compliance with World Trade Organisation.IPR and Research & Development.(Prior intl discussions in 2000).

Scientist And Observer

Ecological Economics, Sustainable Development and Carbon Credits (Common Good)Forests provide several environmental services, through carbon sequestration (carbon credits), oxygen generation, water & soil conservation, and flood control. Oceans also.When carbon taxes are paid and carbon credits are earned, this is a huge amount, when scaled over a whole region, years and decade(s)This serves to benefit sustainable development in all areas, including healthcare, education, public transport, joint ventures, 17SDG 3R Renewables, forestry, agriculture, environment/conservation, MSME, (public debt),The total annual financial trade in carbon credits is estimated to be in the range of 400 billion US$ (equivalent) world wide, annually, for the year 2022. Of this amount some estimates suggest80 billion US$ (equivalent), South America50 billion US$ (equivalent), sub-Saharan Africa20 billion US$ (equivalent), South Asia50 billion US$ (equivalent), South East Asia10 billion US$ (equivalent), Europe40 billion US$, North America30 billion US$ (equivalent), China50+ billion US$ (equivalent), Russia5/10 billion (US$ equivalent), central Asia15/25 billion (US$ equivalent), Australia & New ZealandOceans IslandsAnnual estimates for carbon credits for the previous decades are similar, and less than these current estimatesReference year for omitted and due payments, 1950 (UNO)World leaders, Scandinavian countries (1970)As multi-lateral, multi-country and multiple, intercontinental frameworks, worldwide, the peace dividends are enormous in time and scale (SDG)c/o SDG UNEP UNDP FAO UNFF UNICEF UNFCCC UNIDO IPCC WMO WHO UNWomen UNESCO ILO UNOCHA UNHCR WFP UNDRR EEA UNSDSN, regional and intl development banks, i.e. Asian Development Bank, African Development Bank, World Bank IADB NDB GCF, annual conferences, all regions, areas and subjects, (not WEF)If you want to go far, go together If you want to go fast, go aloneLeave none behindAfrican Wisdom

Drug Discovery Research for Tropical Diseases.Malaria, Leishmaniasis.Biology, Lead discovery, Project management.focused libraries, natural product-like compounds, cell-based screening.

Biofuels, Transport And Carbon Cycles

BioFuels, Transport and Carbon CyclesCarbon CyclesCarbon Emissions of Surface-Transport and Conversion by photosynthesis in Forests, Farms and Oceans.Time scale is 1 to 2 weeks (summer) or 3 to 4 weeks (winter).Altitude is below 500m above ground level.Respiration in Forests and Farms and Photosynthesis.Time scale is one day or 24 hrs.Altitude is below 100m above ground level, (e.g. redwoods and baobab trees)Bio-Diesel is lamp oil (18th century)Bio-Ethanol is whisky science (before 18th century)Low energy quotient (output / input)Ground Level. $$?Keeling Curve measurements; Mauna Loa Observatory Hawaii, 3397mslCommentsCritical reviews are overdue, and are not to be seen anywhere, (ref UNEP).No real benefits for small "Island States" and sea level rise (2100 CE).c/o UNEP, UNDP, UNICEF, UNESCO, WMO, GCP, FAO, WFP, IOM, ILO, UNIDO, ICJ, UNHRC, UNODA, EEA, EUREC, LSE, BGCI, UNSDSN, EPA, WHRC (MA, USA), EarthDay, DAI (USA), TWAS, ISC, CIPSH, IPU, UNGA, UNSC, WB, IADB, CDB, EBRD, AfDB, ADB, NDB, WTO, REN21, IRENA, IPB, IFEU, SEI (SE), ICRC, Pugwash, IFS, Grameen, GBM, IUCN, WWF, CGIAR, CIFOR, ICRISAT, Trees for the Future, TERI, ATREE, DevAlt, CSE, CES (IISc), et al(not WEF, Bilderberg)intellectual level, unclassified.

Bentham Science Publications

Tropical Diseases, Malaria, Tuberculosis, Natural Products

Europe, North America, South & Central America, Africa, Asia And Oceania.

Rare DiseasesMedicines, Vaccines, Diagnostics and Medical Devices.Research and Development, Production and Distribution.Reviews completed.

Bentham Science Publications

Tropical Diseases, Malaria, Tuberculosis, Natural Products

Asia, Africa, South & Central America, Oceania, Europe And North America

Tropical DiseasesMedicines, Vaccines, Diagnostics and Medical Devices.Research and Development, Production and Distribution.no loss. Reviews completed 2005 to 2012.

in vitro Biology Biochemical Screening in vitro ADMENP like compounds

Infectious diseases Lead discoveryBiology.

Tropical diseasesMalaria Tuberculosis Lead discovery BiologyProject Leader, Research Team Leader

Heidelberg Area, Germany

Program of Biological Structures. Dr Dimitrius Tsernoglou.Protein Folding in the CellMolecular chaperones of bacteria (E coli) Structure-function relationship.protein crystallography (6 Angstrom, unpublished)GroEL (nucleotides, peptides), apo-protein and 3 liganded statesSecA (nucleotides, peptides), apo-protein and 3 liganded statesSecB (peptides), apo-protein and 1 liganded stateATP hydrolysis and the local energy minimum in protein-folding, GroEL/GroES, DnaK.Model peptides of L-AAs (leader sequence) and D-AAs (Melittin).No stereo-specificity or selectivity in peptide binding and ATP hydrolysis. No energy transduction of ATP hydrolysis and the local energy minimum in protein-folding (unpublished, GroEL/GroES, DnaK).Protein Folding in the CellCollaborations:Peptide Synthesis Dr Mathias Mann, EMBL Heidelberg, Heidelberg, Germany.GroEL/GroES Dr Costa Georgopoulos, Dept of Biochemistry, University Utah, University GenevaGroEL/GroES 2D crystals and electron microscopy. Dr K Lennard, EMBL, Heidelberg.DnaK/DnaJ/GrpE Dr Costa Georgopoulos, Dept of Biochemistry, University Utah, University GenevaSecA Dr Shoji Mizushima, Inst of Microbiology, University Tokyo, JapanSecB Dr P J Bassford, Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, USASRP48/FtsY Dr B Dobberstein, EMBL-Heidelberg, Heidelberg, Germany.ATP phosphorothioate analogs Dr F Eckstein, MPI Exptl Medicine, Dept of Chemistry, Goettingen, Germany.? Molecular chaperones of Mitochondria, Fungi, Parasites ?Infectious Diseases, Tropical DiseasesEMBL’s European Bioinformatics Institute (EMBL-EBI), Hinxton, UK(AdenoViruses, L Philipson, DG) (Semliki Forest Virus, S Fuller, Program of Biological Structures) (Trypanosome brucei, surface antigens, P Metcalfe, Program of Biological Structures)(Bacterial Elongation Factors, R Leberman, S Cusack, EMBL Grenoble)(Bacterial Toxins, Colicin, Aerloysin, F Pattus)

Read the Conference Reports and Proceedings1988 Thailand1992 Florida? .... 1996, 2000, 2004, 2008, 2012, 2016, 2020, 2024 .... ?

Heidelberg, Germany

Dept Biophysics. Prof Dr K C Holmes et al.,G-proteins and cancer Structure-function relationshipsMutations and OncogenesisOther activities:(BetriebsRat) Works Council, Health, Safety and Environment

Bachelor Of Science (Bs), Diplom (M Sc), Dr Rer Nat (Ph D), Dr Of Science (Biology), Biology

Activities and Societies: Biological Chemistry, Molecular Biology, Cell Biology, Biophysics, Organic Chemistry, Environmental Sciences,

Bachelor Of Science (Bs), Biology/Biological Sciences

A Levels, Biology Chemistry Mathematics

Activities and Societies: sports and music

Std 12, Indian School Certificate, Biology, Chemistry, Physics, Mathematics, English, Hindi, German

Activities and Societies: sports music debating

Std 10. Indian Certificate Of Secondary Education, Biology, Chemistry, English, Geography, Hindi, History, Physics, Religion & Philosophy.

Activities and Societies: sports, debating, music, theater,