Jennifer Hahn Email and Phone Number

Cumming School of MedicineDepartment of Clinical NeuroscienceHotchkiss Brain Institute; endMS NetworkSupervisor: Dr. V Wee YongInvestigating the role of the matrix metalloproteinase-inducer, EMMPRIN, in T cells in multiple sclerosis.Funded by the MS Society of Canada (2013 - present)Publications:Kaushik D.K., Hahn J.N., Yong V.W., EMMRIN, an upstream regulator of MMPs, in CNS biology. Matrix Biology, Special issue of Metalloproteinases in extracellular matrix biology, invited review, submitted (2014).Selected Abstracts:1) Jennifer N. Hahn, Janet Wang, Claudia Silva, Manoj Mishra, V.Wee Yong. Impact of minocycline and established MS medications on EMMPRIN, a new factor implicated in MS immunopathogenesis. 12th International Congress of Neuroimmunology (ISNI) and 14th Esni course: Rheingoldhalle Mainz, Germany; Nov 2014.2) Jennifer N. Hahn, Janet Wang, Claudia Silva, Manoj Mishra, V.Wee Yong. Impact of minocycline and established MS medications on EMMPRIN, a new factor implicated in MS immunopathogenesis. MS Boston 2014 – Joint ACTRIMS-ECTRIMS Meeting; John B. Hynes Veterans Memorial Convention Center, Boston, Massachusetts, U.S.A.; Sept 2014.3) Jennifer N. Hahn, Claudia Silva, Smriti M. Agrawal, Voon-Wee Yong. Expression and mechanisms of EMMPRIN in T cell activation. National endMS Conference; Manoir St-Sauveur, Québec, Canada; Dec 2013.

Cumming School of MedicineDepartment of Biochemistry and Molecular BiologySupervisor: Dr. Frank JirikInvestigated the function of Smad4 (a central mediator in the TGFbeta signaling pathway) in cells of the immune system in a Helicobacter-induced gastric neoplasia model.

Faculty of MedicineDepartment of Biochemistry and Molecular BiologySupervisor: Dr. Frank JirikThesis Title: Smad4-deficiency in hematopoietic cells leads to the development of gastro-duodenal polyps that are accompanied by a Th17 inflammatory responsePublications: Hahn, J.N., Falck, V.G., and Jirik, F.R. Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. The Journal of Clinical Investigation (2011) 121(10):4030-4042.Tsutsui, S., Hahn, J.N., Johnson, T.A., Ali, Z., and Jirik, F.R. Lack of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis (EAE). American Journal of Pathology (2008) 173(4):1029-1041. Sandercock, L.E., Hahn, J.N., Li, Li., Luchman, H., Giesbrecht, J.L., Peterson, L., and Jirik, F.R. Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis (2008) 29(4): 866-874.Selected Abstracts:1) Jennifer N. Hahn, Vincent G. Falck, Frank R. Jirik. Conditional deletion of Smad4 in T cells leads to Th17-mediated development of gastric polyps in mice. Keystone Symposia: TGF-β in Immune Responses: From Bench to Bedside; Snowbird Resort, Utah, U.S.A.; January 2011.2) Jennifer N. Hahn, Vincent G. Falck, Frank R. Jirik. Conditional deletion of Smad4 in T cells leads to gastric polyps. Keystone Symposia: Role of Inflammation in Oncogenesis; Keystone, Colorado, U.S.A.; February 2010.Awards:-Second annual Dean’s Publication and Mentorship Prize competition-MS Society of Canada Studentship-William H. Davies Medical Research Scholarship-Graduate Research Scholarship-Graduate Travel Award-Dean’s Research Excellence Scholarship-NSERC CGSM Studentship-Dean’s Entrance Scholarship

Faculty of ScienceDepartment of Biological SciencesSupervisor: Dr. RE HuberPublication:Wheatley, R.W., Kappelhoff, J.C., Hahn, J.N., Dugdale, M.L., Dutkoski, M.J., Tamman, S.D., Fraser, M.E., and Huber, R.E. Substitution for Asn460 cripples -galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability. Arch Biochem Biophys. (2012) 521(1-2): 51-61.