Jennifer Lee Email & Phone Number

Bethesda, Md

Investigating the use of pH responsive, cationic nanoparticles for efficienct delivery of siRNA targeting DNA repair pathways to modulate the radiosensitivity of glioblastoma (Collaboration with Dr. Zheng-Rong Lu, Department of Biomedical Engineering, Case Western Reserve University)

Gainesville, Fl

Characterization of the effects of aerobic exercise on mammary tumor perfusion and hypoxia and its impact on radiation therapy- Histological analyses of vessel density, perfusion, and hypoxia in orthotopic murine tumors- First-pass fluorescence imaging of blood transit time and hyperspectral imaging of hemoglobin saturation of tumor microvessel oxygenation in the dorsal skinfold window chamber model- Photoacoustic imaging of tumor perfusion and hypoxia in orthotopic murine mammary tumors (collaboration with Dr. Huabei Jiang, Department of Biomedical Engineering – University of Florida)Investigation of the effects of obesity on tumor physiology- Histology, growth delay, clonogenic cell survivalInvestigation of tumor distribution of systemically administered nanoparticles- Fluorescence detection of magnetic nanoparticles in tumors within the dorsal skinfold window chamber model (collaboration with Dr. Carlos Rinaldi, Department of Biomedical Engineering - University of Florida)

Gainesville, Fl

Combination of first-pass fluorescence (FPF) imaging with hyperspectral imaging of hemoglobin (Hb) saturation for wide-field in vivo analysis of microvessel blood supply and oxygenation within the murine skin dorsal window chamber model- Designed and developed FPF imaging technique - video tracking of fluorescent liposomes as they first enter microvessels within the field of view to calculate blood supply time• Developed near-infrared fluorescent liposomes for fast clearance, reduced extravasation• Measured microvascular effects of the vascular targeting agents OXi4503, Cediranib and Sunitinib on human renal cell carcinoma (Caki-2) and human prostate tumors (PC-3)• Evaluated vessel development during uninhibited tumor growth (4T1, Caki-2, PC-3) • Characterized angiogenesis in wound healing Murine dorsal skinfold window chamber work- Surgically implanted titanium dorsal skinfold window chambers on immunocompromised mice and performed subcutaneous injections of tumor cells for in vivo monitoring of tumor growth and response to vascular targeting agents- Assessed the utility of the dorsal skinfold window chamber model for evaluating antiangiogenic agents (small molecule inhibitor (Sunitinib) and monoclonal antibodies (anti-Ang2-antibody, MedImmune LLC)Application of differential laser-induced perturbation spectroscopy for the non-invasive detection and staging of oral cancer (collaboration with Dr. David W. Hahn, Department of Mechanical Engineering - University of Florida)- Assisted in the optimization of technique in murine skin and hamster cheek pouch modelsFabrication of gold nanorods for targeted uptake by macropahges for immunodelivery to tumors and photothermal therapy via diode laser irradiation- Characterized uptake of gold nanorods by murine macrophages- Observed distribution of fluorescently labeled macrophages (intravenously injected) in tumors in the window chamber

Pittsburgh, Pa

- NSF American Student Placements and Internships in Rehabilitation Engineering REU - Assisted physical therapists with data collection of wheelchair propulsion forces from spinal cord injury patients at the University of Pittsburgh Medical Center – Southside using SmartWheel technology- Developed an interactive, clinical website to educate clinicians and encourage the implementation of “Guidelines for Prevention of Upper Limb Pain in Spinal Cord Injury”

Doctor Of Philosophy (Phd), Biomedical Engineering

Thesis: Combination of first-pass fluorescence imaging with hyperspectral imaging of hemoglobin saturation for wide-field in vivo analysis.

Bachelor Of Science - Bs, Biomedical Engineering