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Jennifer Bramen, PhD is a neuroscientist with expertise in neuroscience research, advanced neuroimaging, and non-pharmacological interventions for cognitive decline. She obtained her PhD in Neuroscience from the University of California, Los Angeles (UCLA), where she also completed her postdoctoral research fellowship at the Laboratory of Neuroimaging (LONI). During her time as an Assistant Research Neuroscientist at the UCLA’s Center for Cognitive Neuroimaging, she made significant contributions to the field. She published groundbreaking work on real-time fMRI technology aimed at in-scanner neurofeedback to reduce craving levels in smokers. As part of her work with the UCLA Center on Aging, she conducted research focused on the early diagnosis of Alzheimer's disease using techniques such as FDG PET and hippocampal unfolding. She was also a lecturer in the Neuroimaging Training Program.Dr. Bramen currently serves as a Senior Research Scientist at the Pacific Neuroscience Institute Foundation (PNIF), an emerging neuroscience research organization housed within the Pacific Brain Health Center (PBHC), an outpatient dementia care clinic and center of excellence in the Providence St. Joseph Health system. At PBHC, she leads the Neuroimaging Core, which provides neuroimaging-based biomarkers and supports automated data abstraction from the electronic health record to facilitate a better understanding clinical outcomes and measure the efficacy of clinical trials. Dr. Bramen's research primarily focuses on interventions for Alzheimer's disease (AD) and related dementias. She has made notable contributions to the field as the inventor of AD-NeuroScore, a novel sMRI-based metric that utilizes clinically available measures and a novel (patent pending) algorithm to assess neurodegeneration associated with AD. AD-NeuroScore is distinguished by its clinical feasibility, interpretability, and its potential to improve the patient experience. It accounts for variations in scans performed at different facilities with different scanners, ensuring the validity of longitudinal follow-up reports. Furthermore, Dr. Bramen is engaged in intervention research aimed at improving multi-modal lifestyle interventions. She employs a combination of coaching and precision-medicine to improve behavior change. She also collaborates with the Institute for Systems Biology (ISB) on systems biology research to improve personalized medicine by understanding the complex interactions between environment, genetics, and physiological systems measured using metabolomics and proteomics.
Pacific Neuroscience Institute Foundation
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Director, NeuroimagingPacific Neuroscience Institute Foundation Jan 2024 - Present -
Senior Research ScientistPacific Neuroscience Institute Foundation Apr 2021 - PresentWork alongside clinician-scientists at the Pacific Brain Health Center to bridge the gap between the translational research pipeline and full clinical implementation.Spearhead the Pacific Neuroscience Institute Foundation’s new Neuroimaging Core, which will provide neuroimaging-based biomarkers for clinical trials research. Develop and write new research protocols and grant applications. Promote PNIF through public speaking and educate the public about brain health through outreach.Current Research• Efficacy of coaching in preventing cognitive decline in patients with MCI and AD using a precision medicine driven, multi-modal lifestyle intervention. • Efficacy of simultaneous aerobic exercise and a novel, mobile compensatory skills training to prevent cognitive decline in patients with aMCI. • Understanding how immune-exposure, reproductive history, childhood stress and other important developmental factors impact inflammation and tauopathy in women with Alzheimer’s disease.• Efficacy of psychedelic-assisted therapies in treating addiction. -
Senior Program ManagerPacific Brain Health Center/Pacific Neuroscience Institute Jan 2019 - PresentMultidimensional role, broadly operationalized as the development and implementation of novel research and clinical trials conducted at the Pacific Neuroscience Institute’s Pacific Brian Health Center (PBHC) which aim to promote brain health and wellness. Developed and implemented new programming for research studies and oversaw development of technology required for programming for research studies. Hired and supervised the clinical trials team. Oversaw the recruitment, retention, and data capture of participants engaged in PBHC research studies.
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Brain-Based CoachLivecoach Jan 2016 - Dec 2020San Francisco, California, Us -
Assistant Clinical Director/ Brain-Based CoachPeak Brain Institute Jan 2018 - Jan 2019Culver City, Ca, UsTransformed day-to-day operations and data management for a national, multi-site and fast-paced neurofeedback clinic. Developed a new daily operations and data-management application using Zoho Creator. Application maintained customer charts, automatically sent daily surveys to customers and integrated their responses with their charts. The system also created a client portal so customers to see progress and their personal brain data. Resulted in daily updates to the staff including automated instructions that improved neurofeedback protocol selection. Supervised a smooth data migration and staff transition to new daily operations and data-management system. System adopted by four clinics in two states.Spearheaded a new coaching program which integrated customer goals with their personal brain data. Integrating coaching tools with day-to-day customer interactions increased customer awareness of intervention benefits and satisfaction with services. Managed staff and technicians and trained them in the use of simple coaching tools related to goal setting. -
Data ScientistSmrtimage Nov 2014 - 2016Offered advanced fMRI expertise to pharmaceutical and clinical trial companies such as Pfizer and Parexel. These included experimental design, data quality control, maintaining equipment needed to present cognitive tasks in a magnetic environment, data collection an analysis. Design fMRI experiments and plan analyses in a Phase 0 clinical trial study. Tested whether new psychiatric medications were affecting planned brain targets in psychiatric populations. Resulted in strong evidence that a Schizophrenia medication geared at treating cognitive symptoms was impacting cognitive centers in the bain. Managed a staff of 6 technicians. Worked closely with clinical trial company to integrate fMRI data and other clinical data collection.
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Assistant Research NeuroscientistUcla Department Of Psychiatry May 2008 - Jun 2014Los Angeles, Ca, UsManaged 22 research studies and 12 researchers associated with a $3.5M NIH Technology Development Award. Studies focused on study real-time functional imaging (mind reading). Created a new laboratory environment, assisted in the selection of personnel, managed the physical and intellectual resources, and instructed students and postdoctoral research fellows in neuroimaging techniques. The resulting lab environment attracted an exceptional, multi-disciplinary team.Balanced workloads and priorities for a staff of research professionals conducting functional MRI and EEG research studies. Fostered a cohesive, collaborative approach to multi-disciplinary scientific research by understanding the ideas and skills of researchers from several very different scientific disciplines. Ensured that the work maintained relevance to both how the brain works and clinical applications.Applied machine learning tools like support vector machines (SVM) and cluster analysis to multi-modal brain data (PET, s/fMRI and EEG) to create cutting-edge clinical applications. One study focused “mind-reading” technology. Specifically, we developed a tool that identified craving level using whole brain data analyzed and presented as feedback within 2 seconds. Also developed a computer assisted diagnostic (CAD) tool for diagnosing Epilepsy using standard clinical EEG, MRI and PET data.Co-authored 9 original manuscripts in 3 years. -
Postdoctoral Fellow/ Data Analyst/ Data ScientistUcla Department Of Psychiatry Sep 2007 - Dec 2009Los Angeles, Ca, UsCo-authored a funded $4.5M NIH Research Grant on Sex Difference in Adolescent Brain Development.Authored 2 and co-authored 3 original manuscripts on adolescent brain development in 2 years.Created a private Cloud-based neuroimaging pipeline for data storage, distribution and analysis saving more than 400 man-hours annually. -
Graduate StudentUniversity Of California, Los Angeles - Ahmanson-Lovelace Brain Mapping Ct (Bmc) Jan 2001 - Aug 2007Created a better, working prototype of a new MRI compatible smoke delivery device. The schematics, limitations, and my solutions were published online. Harvard currently uses a working version based on these. Project had $4M of NIH fundingPlanned and implemented fMRI and psychophysics experiments to better understand time perception and multi-sensory integration. Wrote and defended my doctoral dissertation and was awarded a Ph.D.
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Staff Research Associate IiUniversity Of California, Los Angeles - Aging And Memory And Hatos Research Cts Sep 1997 - Feb 2000Los Angeles, Ca, UsI assisted with aging and memory researcher and author Gary Small, MD when he was building his research center. I balanced Neuroimaging responsibilities and high volume clinical administration. • Staff Recruitment: Successfully recruited two research assistants. Each were successful and retained by the center for more than one year. Responsible for job descriptions, posting, interviewing the candidates and training the staff, once hired.• Project Manager: Established procedures and policies for participant recruitment, tracking, and data completion for a large-scale, placebo controlled clinical study on the drug Celebrex.• Earned four promotions in first year, tripling salary.• Marketing: Increased recruitment through aggressive ad campaigns in Senior Life, Los Angeles Times, National Public Radio, and CNN. • Fundraising: Supported a $100K fundraising gala and auction sponsored by Janssen-Cilag by entertaining Janssen reps and representing lab to attending professors. Event so successful Janssen agreed to fund following year’s event.
Jennifer Bramen Skills
Jennifer Bramen Education Details
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UclaNeuroscience
Frequently Asked Questions about Jennifer Bramen
What company does Jennifer Bramen work for?
Jennifer Bramen works for Pacific Neuroscience Institute Foundation
What is Jennifer Bramen's role at the current company?
Jennifer Bramen's current role is Director, Neuroimaging at Pacific Neuroscience Institute FoundationAssistant Professor at Saint John's Cancer Institute.
What is Jennifer Bramen's email address?
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What is Jennifer Bramen's direct phone number?
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What schools did Jennifer Bramen attend?
Jennifer Bramen attended Ucla.
What are some of Jennifer Bramen's interests?
Jennifer Bramen has interest in Children.
What skills is Jennifer Bramen known for?
Jennifer Bramen has skills like Neuroscience, Science, Experimental Design, Data Analysis, Research, Cognitive Neuroscience, Neuroimaging, Experimentation, Matlab, Statistics, Machine Learning, Mri.
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