Jennifer A. Codding-Bui, Ph.D. Email and Phone Number
Jennifer A. Codding-Bui, Ph.D. work email
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Jennifer A. Codding-Bui, Ph.D. personal email
Ph.D. protein biochemist with significant experience characterizing and engineering antibodies, enzymes, and biologics. Expertise in utilizing bioanalytical techniques and biochemical and cell-based assays to produce proteins and to characterize protein-ligand interactions, enzyme and affinity kinetics, protein folding and stability, mechanism-of-action studies, structure-function relationships, protein-substrate specificity, and enzyme pathways in neurodegenerative diseases. Specialties: SPR, Octet (BLI), affinity kinetics, enzyme kinetics, protein characterization, bioanalytical techniques, biochemical & cell-based assay development, recombinant protein engineering & expression, protein purification (AKTA), protein folding, quantitation and kinetic analysis, biochemistry, cell and molecular biology, redox chemistry, neurological diseases, inhibitor characterization and development, confocal microscopy, primary neuronal cell culture, animal models, leadership, interpersonal communication, and scientific editing and writing.
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Senior Scientist, Protein EngineeringAtum Sep 2020 - PresentNewark, Ca, Us Apply ATUM’s proprietary GPS bioengineering technology combining Design of Experiment (DoE), empirical measurements requiring protein, and Machine Learning (ML) toward multiparametric optimization of therapeutic antibodies Lead internal and external protein engineering efforts as part of ATUM’s ProteinGPS team Develop high-quality, analytical assays (including quantifying binding dynamics by SPR and octet) and use ML to evaluate the impact of variables, enabling the directed engineering of new variants
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Senior ScientistDistributed Bio Inc Jan 2020 - Jun 2020Within the kinetics screening department, I utilized the Octet HTX to screen and characterize the binding properties of thousands of high affinity developable antibodies against drug targets of interest.
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Field Applications ScientistFortebio Dec 2017 - Jan 2020Fremont, Ca, UsAs an FAS with ForteBio, I trained scientists in applying the best methods for biomolecular interaction studies to their research efforts. I contribute to pharmaceutical, biotech, academic, and government research by designing and running Octet BLI and SPR experiments, analyzing data, troubleshooting, and helping our clients to develop novel applications. -
Independent ConsultantQuintara Discovery 2017 - 2017 -
Research ScientistCircuit Therapeutics Mar 2016 - Jul 2016As a Scientist on the Parkinson's Disease Team, my project probed enzyme mechanisms in primary neuronal cultures by way of micro-titer plate based readout cellular assays to aid in the development of PD therapeutics. A second area of focus involved characterizing the safety of optogenetic therapeutic parameters by assessing brain tissue through immunohistochemistry and confocal microscopy.
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Nrsa Postdoctoral FellowStanford University School Of Medicine Oct 2014 - Feb 2016Palo Alto, Ca, UsAdvisor: Xinnan Wang, Ph.D.The goal of my NIH-sponsored research in Dr. Xinnan Wang’s laboratory at Stanford was to determine the role of mitochondria motility and distribution in stroke pathophysiology and to identify the underlying enzyme mechanisms leading from stroke-like injury to mitophagy toward biomarker identification. This project allowed me to establish a primary neuronal cell culture model, to image mitochondrial transport and distribution in primary hippocampal neurons, and to identify mechanistic changes upon stroke-like injury by western blot analysis and cell-based assays. -
Postdoctoral Research ScientistColumbia University May 2013 - Sep 2014New York, Ny, UsAdvisor: Carol Troy, M.D., Ph.D.My F32 sponsored postdoctoral research at Columbia University examined the edema-specific downstream substrates of caspase-9, an early mediator of ischemic stroke. In addition to utilizing in vitro and cell culture techniques to characterize this pathway, I studied the effects of knocking out or inhibiting caspase-9 and MMP9 in stroked animals to determine the cell-specific contributions of caspase-9 activation during stroke in endothelial cells and in neurons. While I learned much from being the team lead on this project, I chose to transfer to Stanford when my husband received a position in R&D in the Bay Area. -
Doctoral Research AssistantUniversity Of Delaware Sep 2006 - Jan 2013Newark, De, UsAdvisor: Colin Thorpe, Ph.D.During graduate school, I led and completed a project exploring the substrate tolerances of the endoplasmic reticulum flavoprotein Quiescin Sulfhydryl Oxidase (QSOX), which incorporates disulfide bonds into proteins via the transfer of electrons to molecular oxygen. The precise role of the QSOX family is currently under debate, and this timely in vitro study advanced our understanding of QSOX’s potential capabilities inside of the cell. A second body of work primarily utilized redox trapping assays to probe the redox equilibria between the chaperone Protein Disulfide Isomerase and QSOX, and their respective substrates. Both projects allowed me to gain expertise in several molecular biology and biochemical techniques, including the expression and purification of recombinant wild type and mutant enzymes; biochemical activity assays; and redox chemistry techniques. -
Chemistry And Biology Interface (Cbi) Rotation StudentUniversity Of Delaware Aug 2006 - Feb 2007Newark, De, UsAdvisor: John Koh, Ph.D.Biosynthetic incorporation of unnatural amino acids to allow chemistry to function independent of functional groups found in proteinsAdvisor: Roberta Coleman, Ph.D.Characterization of intersubunit complementation between two mutants of human adenylosuccinate lyase to increase comprehension of adenylosuccinate lyase deficiencyAdvisor: Thomas Beebe, Ph.D.Optimization of directional control of axonal outgrowth as a function of substrate to control axon regrowth in the nervous system
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InternOak Ridge National Lab Aug 2005 - Dec 2005Oak Ridge, Tn, UsMentor: Wei Wang, Ph.D.During the fall semester of my senior year I was an intern at Oak Ridge National Laboratory in the Environmental Science Division working under the direction of Dr. Wei Wang. Continual questions from interested post-docs and research scientists challenged me to understand the drug delivery and environmental applications of optimizing the synthesis and characterization of tin oxide nanoparticles. This experience reinforced my decision to pursue a career in science. -
Undergraduate Research AssistantMcmurry University May 2004 - Aug 2005Abilene, Tx, UsAdvisor: Professor Arlen JefferyI conducted organic research with Dr. Arlen Jeffery on the synthesis and kinetic characterization of novel carbohydrates to inhibit the replication of the enzyme human immunodeficiency virus reverse transcriptase. Working directly with my advisor for two summers as an undergraduate taught valuable lessons, and I wrote my honors thesis on this research.
Jennifer A. Codding-Bui, Ph.D. Skills
Jennifer A. Codding-Bui, Ph.D. Education Details
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University Of DelawareChemistry And Biochemistry -
Mcmurry UniversityBiochemistry; Religion
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Artesia High SchoolChemistry
Frequently Asked Questions about Jennifer A. Codding-Bui, Ph.D.
What company does Jennifer A. Codding-Bui, Ph.D. work for?
Jennifer A. Codding-Bui, Ph.D. works for Atum
What is Jennifer A. Codding-Bui, Ph.D.'s role at the current company?
Jennifer A. Codding-Bui, Ph.D.'s current role is Senior Scientist, Protein Engineering at ATUM.
What is Jennifer A. Codding-Bui, Ph.D.'s email address?
Jennifer A. Codding-Bui, Ph.D.'s email address is je****@****bio.com
What schools did Jennifer A. Codding-Bui, Ph.D. attend?
Jennifer A. Codding-Bui, Ph.D. attended University Of Delaware, Mcmurry University, Artesia High School.
What are some of Jennifer A. Codding-Bui, Ph.D.'s interests?
Jennifer A. Codding-Bui, Ph.D. has interest in Large Molecules, Protein Analytics, Aggregation, Immuno Oncology, Molecular Pharmacology, Health, Children, Protein Therapeutics, Education, Science And Technology.
What skills is Jennifer A. Codding-Bui, Ph.D. known for?
Jennifer A. Codding-Bui, Ph.D. has skills like Chemistry, Uv/vis, Western Blotting, Biochemistry, Mass Spectrometry, Fplc, Protein Chemistry, Fluorescence Spectroscopy, Molecular Biology, Cell Culture, Protein Expression, Enzyme Kinetics.
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