Jennifer Shell Email & Phone Number

Tazewell, Tn, Us

Jacksboro, Tn, Us

• Develop imaging agents and theranostics for diagnosis and treatment of aggressive cancers such as pancreatic cancer and glioblastoma • Oversee all aspects of drug development, assay development, clinical studies of X-ray activated vitamin B12-based chemotherapeutics

Knoxville, Tennessee, United States

● Expanded my research involving the cobalamin technology to develop X-ray activated theranostics for potential diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC)● Consulted with research groups in the Thayer School of Engineering to advise projects that included medical imaging applications such as tumor oxygenation utilizing oxygen sensitive luminescent probes that are excited by the Cherenkov light emitted during radiotherapy as well as the development of a protocol… Show more ● Expanded my research involving the cobalamin technology to develop X-ray activated theranostics for potential diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC)● Consulted with research groups in the Thayer School of Engineering to advise projects that included medical imaging applications such as tumor oxygenation utilizing oxygen sensitive luminescent probes that are excited by the Cherenkov light emitted during radiotherapy as well as the development of a protocol for an in-cell western technique to better elucidate the mechanism of action of a targeted cancer drug on its downstream pathways• Grant writing Show less

● Grant writing● Determination of cell viability of light-activated vitamin B12-drug conjugates in a variety of cancer cell lines

Taught general chemistry lecture and laboratory

● further development of biological applications for the cobalamin platform, with a focus on light- activated cancer chemotherapy● development of a light-activated cobalamin-based hydrogel● accomplished HepG2 cell encapsulation in the hydrogel with an eye towards medical applications● grant writing

Research Advisor: David S. Lawrence● developed assays for early cancer screening and treatment identification ● investigated compartmentalized activity of mitochondrial protein kinase A discovered a new mechanism of regulation of protein kinase A activity via digestion of the regulatory subunits by calpain● developed biological applications for light-activated cobalamin-drug conjugates

● Taught general chemistry lecture and laboratory for chemistry majors as well as general chemistry, organic chemistry and biochemistry for nursing majors● Developed a teaching laboratory experiment for microwave-assisted synthesis of maleimides and succinimides

Taught organic chemistry lecture and laboratory

Atlanta, Georgia, United States

Research Advisor: Debra L. Mohler● studied of photochemotherapeutics that oxidatively damage DNA in a spatial and temporal manner● synthesis and mechanistic studies of DNA cleavage by organometallic complexes that generate carbon radicals upon illumination with light● investigated the toxicity of these organometallic complexes in a variety of cancer cell lines● utilized these organometallic complexes to investigate the structural changes that occur in chromatin … Show more Research Advisor: Debra L. Mohler● studied of photochemotherapeutics that oxidatively damage DNA in a spatial and temporal manner● synthesis and mechanistic studies of DNA cleavage by organometallic complexes that generate carbon radicals upon illumination with light● investigated the toxicity of these organometallic complexes in a variety of cancer cell lines● utilized these organometallic complexes to investigate the structural changes that occur in chromatin remodeling during transcription● accomplished the synthesis of modified DNA bases● taught organic chemistry laboratory● served as a teaching assistant for biochemistry Show less

Charleston, South Carolina, United States

Taught general chemistry laboratory

Bachelor Of Science - Bs, Chemistry

Doctor Of Philosophy - Phd, Chemistry