Jennifer Shell Email & Phone Number

Tazewell, TN, US

Jacksboro, TN, US

• Develop imaging agents and theranostics for diagnosis and treatment of aggressive cancers such as pancreatic cancer and glioblastoma
• Oversee all aspects of drug development, assay development, clinical studies of X-ray activated vitamin B12-based chemotherapeutics

Knoxville, Tennessee, United States

• Expanded my research involving the cobalamin technology to develop X-ray activated theranostics for potential diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC)
• Consulted with research groups in the Thayer School of Engineering to advise projects that included medical imaging applications such as tumor oxygenation utilizing oxygen sensitive luminescent probes that are excited.
• Consulted with research groups in the Thayer School of Engineering to advise projects that included medical imaging applications such as tumor oxygenation utilizing oxygen sensitive luminescent probes that are excited.
• Grant writing Show less

• Grant writing
• Determination of cell viability of light-activated vitamin B12-drug conjugates in a variety of cancer cell lines

Taught general chemistry lecture and laboratory

• further development of biological applications for the cobalamin platform, with a focus on light- activated cancer chemotherapy
• development of a light-activated cobalamin-based hydrogel
• accomplished HepG2 cell encapsulation in the hydrogel with an eye towards medical applications
• grant writing

• Research Advisor: David S. Lawrence
• developed assays for early cancer screening and treatment identification
• investigated compartmentalized activity of mitochondrial protein kinase A discovered a new mechanism of regulation of protein kinase A activity via digestion of the regulatory subunits by calpain
• developed biological applications for light-activated cobalamin-drug conjugates

• Taught general chemistry lecture and laboratory for chemistry majors as well as general chemistry, organic chemistry and biochemistry for nursing majors
• Developed a teaching laboratory experiment for microwave-assisted synthesis of maleimides and succinimides

Taught organic chemistry lecture and laboratory

Atlanta, Georgia, United States

• Research Advisor: Debra L. Mohler
• studied of photochemotherapeutics that oxidatively damage DNA in a spatial and temporal manner
• synthesis and mechanistic studies of DNA cleavage by organometallic complexes that generate carbon radicals upon illumination with light
• investigated the toxicity of these organometallic complexes in a variety of cancer cell lines
• utilized these organometallic complexes to investigate the structural changes that occur in chromatin … Show more Research Advisor: Debra L. Mohler
• utilized these organometallic complexes to investigate the structural changes that occur in chromatin remodeling during transcription

Charleston, South Carolina, United States

Taught general chemistry laboratory

Bachelor Of Science - Bs, Chemistry

Doctor Of Philosophy - Phd, Chemistry