Jesper Worm Email & Phone Number

Copenhagen, Dk

• Supporting Projects within Neurodegenerative, Cardiovascular diseases and Ophthamology – role as co-project leader• Hands-on Conducting/executing in vitro experiments both screening (high throughput) and MoA studies• Experience with Advanced cellular models e.g hiPSC microglia/neurons/Cardiomyocytes or primary cells e.g. hepatocytes• Testing different MoA for Nucleic acid based medicine – ASO/siRNA/CrisprCas9• Biomarker identification and off-target screening• Making… Show more • Supporting Projects within Neurodegenerative, Cardiovascular diseases and Ophthamology – role as co-project leader• Hands-on Conducting/executing in vitro experiments both screening (high throughput) and MoA studies• Experience with Advanced cellular models e.g hiPSC microglia/neurons/Cardiomyocytes or primary cells e.g. hepatocytes• Testing different MoA for Nucleic acid based medicine – ASO/siRNA/CrisprCas9• Biomarker identification and off-target screening• Making project plans/time plans/decision maps• Presentations to pas milestones e.g. from idea to Target assessment and into portfolio• Filing patents • Outsourcing coordination - CROs • Ensuring fruitful external collaborations with both industrial and Academic partners• Assays:- mRNA: qPCR, ddPCR, broader transcriptomic RNA microarray off-target analysis and pathways Gene Set Enrichment Analysis - Protein high throughput protein assays like SureFire (alpha-screen), HTRF, but also standard ELISAs or SimpleWestern technology- Assays luciferase reporter assays, HiBiT (Promega technology) tagged endogenous proteins- Functional assays: MTS, Caspase, Signaling, Cytokine profiling Show less

• Developing high throughput label-free binding assays for measurements of antibody concentrations using the Octet HTX platform (BLI technology)• Determine binding affinities (binding kinetics) using the Octet HTX platform for drug substance and drug products • Development of several ELISA assays (~10) for measurements of antibody potencies ready for transfer to QC

• Hands on - In vitro/ex vivo assays - Insulin Biology - potency and efficacy data• Established various functional assays like downstream phosphor-protein signalling, adhesion, migration, formation of reactive oxygen species or production of matrix metalloproteases, cytokines or chemokines• Support Insulin research projects and answering questions from authorities e.g. EMA • Supervisor for Postdocs• Establishing external collaborations identify and invite KOL• Arranging… Show more • Hands on - In vitro/ex vivo assays - Insulin Biology - potency and efficacy data• Established various functional assays like downstream phosphor-protein signalling, adhesion, migration, formation of reactive oxygen species or production of matrix metalloproteases, cytokines or chemokines• Support Insulin research projects and answering questions from authorities e.g. EMA • Supervisor for Postdocs• Establishing external collaborations identify and invite KOL• Arranging symposia, coordination of CVD bioforum with external speakers• Manager for 6 Research Scientists and 9 Technicians Show less

• Hands on In vitro potency and efficacy - Assay development for qualifier identification e.g. target receptor signaling e.g. MAPK signalling, PKC activity assays - Chronic kidney disease and vascular calcification• Target idea generation: Target importance, Redundancy, Unmet Need, Competitor landscape mapping• Biology knowledge support• Establishing external collaborations identify contact and invite KOL/external speakers

• In vitro potency and efficacy: Cell culture, Transfection, gene knockdown – qPCR/Western blotting • Functional assays: e.g. protein phosphorylation, reporter assays, Cell viability, Cell death• Biology knowledge support• Identification of future Cancer targets: Target importance, Redundancy• Establish collaborations with KOL within academia• Manager for 2 Research Scientists and 7 Technicians

Post doc at the Laboratory of Molecular Biology, Cambridge, United Kingdom.I worked for two years in the Lab of Mariann Bienz working with wnt signalling.

Phd, Molecular Pathways Involved In Cancer

Activities and Societies: Identifying important genes or pathways involved in malignant melanoma using various experimental molecular.

Master Of Science, Human Biology

Master Of Science, Chemical Engineering