Jessica Orf Email and Phone Number

Scientist, Department of Oncology (June 2018 - present)Senior Associate Scientist, Department of Oncology (January 2009 - June 2018)Associate Scientist, Department of Oncology (January 2006 - January 2009) Senior Research Associate, Department of Oncology (May 2005 - January 2006)-In vivo pharmacology support for multiple programs. Research areas include small molecule and antibody-based immuno-oncology therapeutics, various modalities of tumor immunotherapy and immunomodulatory oncology therapeutics (CAR-T cells, bi-specific T-cell engagers, monoclonal antibodies, bispecific antibodies, oncolytic virus)-Model development for efficacy, PK/PD, mechanism of action, safety and tolerability studies-Coordinate and conduct in vivo, ex vivo and in vitro experiments to develop and test novel oncology therapies, demonstrate proof-of-concept, characterize and validate oncology targets, study mechanisms of immune-mediated regulation of tumorigenesis, evaluate of PD/PK profiles-Development of cell-based immunoassays for screening/ranking immunotherapy based therapeutics-BiTE program enabling and mechanism of action studies (T cell activation, cytokine production, cytotoxicity, cross reactivity, investigation of BiTE candidate toxicity)-In vitro studies for validation of cancer targets, mechanism of action drug studies, patient selection

Research Associate II, Pharmacology (January 2005-May 2005)Research Associate I, Pharmacology (January 2003-January 2005) Research Assistant II, Pharmacology (August 2001-January 2003)Member of pharmacology department performing efficacy studies, pharmacodynamic and pharmacokinetic studies, development of xenograft models of cancer, mechanism of action studies, assay development. Research areas include oncology and metabolic disorders.

Collect data and maintain database containing functional and phenotypic information on genes selected for their commercial relevance to drug discovery.