Jessica Sacher

Jessica Sacher Email and Phone Number

Palo Alto, CA, US
Jessica Sacher's Location
San Francisco, California, United States, United States
Jessica Sacher's Contact Details

Jessica Sacher work email

Jessica Sacher personal email

n/a
About Jessica Sacher

I love working alongside ambitious people to tackle tough, impactful problems that leverage biology for good. I can be found digging into new areas (like a new lab robot or new assay), making it work, & blogging about my process. 🇨🇦 Edmonton → 🍑 Atlanta → 🦘Sydney → 🌉 San FranciscoWhile completing my PhD on bacteriophages (phages), the 'good' viruses that kill bacteria, I co-founded Phage Directory to help doctors find phage scientists willing to share their phages to rescue patients dying from antibiotic-resistant infections. Phage Directory is now the global phage community's central source of news & connection. We support thousands of phage professionals from 80+ countries, help clinicians source phages for their patients, and help organizations manage, grow & learn from their phage collections. Our 'Phage Alerts' system has helped physicians source phages for 60+ patients across more than a dozen countries, leading to at least 5 lives/limbs saved to date. In early 2022 my Phage Directory co-founder Jan and I joined the team launching Phage Australia, an Australia-wide phage therapy ecosystem. Phage Directory supported the informatics side, helping ensure the team can maximize insights it gets from its phage treatments. In this role I also dove fully back into the lab again, applying what I learned as a startup founder to designing and running the first version of Phage Australia's patient-ready phage manufacturing and QC process. We were able to set up a system that achieved a ~4-8-week turnaround per patient, 18 phage batches for 14 patients in our first year. I spent much of my time writing our SOPs, coming up with better ways of documenting and automating our process, and helping figure out how best to manage and leverage our library of hundreds of phages and unique integrated setting between lab & bedside, so we could go from 1 patient a month to 10 and beyond.As of May 2024 I've joined Paul Bollyky's lab at Stanford University to help set up a phage therapeutics pipeline to support in vivo phage delivery and cocktail development research, as well as clinical trials and compassionate phage treatments. I'm so excited to see what we can build! Alongside my lab roles, I love to write about my challenges and successes in the lab, and how I make decisions and manage the chaos of making patient-ready phages at Phage Australia (https://phageaustralia.org/blog), Jessica's TechBio Adventures (https://jessbio.substack.com/), and Capsid & Tail (https://phage.directory/capsid).

Jessica Sacher's Current Company Details
Stanford University School of Medicine

Stanford University School Of Medicine

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Staff Scientist
Palo Alto, CA, US
Jessica Sacher Work Experience Details
  • Stanford University School Of Medicine
    Staff Scientist
    Stanford University School Of Medicine
    Palo Alto, Ca, Us
  • Stanford University School Of Medicine
    Staff Scientist
    Stanford University School Of Medicine May 2024 - Present
    Palo Alto, California, United States
    - Leading establishment of new therapeutic development center, including infrastructure setup and strategic planning- Developing manufacturing processes and quality systems for clinical-grade phage biologics- Building partnerships with clinical, regulatory, and manufacturing stakeholders
  • Phage Directory
    Co-Founder
    Phage Directory Nov 2017 - Present
    United States
    - Established a global phage crowdsourcing system that lets doctors request patient-personalized bacteriophages from labs around the world when they have patients with antibiotic-resistant, otherwise-untreatable bacterial infections (60+ phage hunts coordinated, 5 cures to date)- Created a public database of 500+ phage research professionals, 150+ labs, and 100+ organizations, and the phages they collect (collections now total 10,000+ phages targeting 170+ bacterial species)- Creator, editor-in-chief and publisher of Capsid & Tail since 2018, a weekly periodical for phage scientists, which has attracted over 1,500 email subscribers from 80+ countries (260+ issues, 40-50% open rate each week).- Hosted 25+ bimonthly virtual phage research seminars (https://phage.directory/youtube) and grew the @phagedirectory Twitter account to 7,000 followers.- Led development of global best practices for phage data management in collaboration with international researchers and phage banks, involving visits to 30 research labs worldwide, and leading to a formal partnership with Westmead Institute for Medical Research’s Phage Australia initiative.- Secured and managed $125,000 in non-dilutive grant funding to support and expand Phage Directory projects, including a $100,000 Grant for the Web from Interledger Foundation to develop Instill Science, a platform for peer-supported manuscript feedback, a $15,000 Open Science Mini-Grant from the Mozilla Foundation to provide phage lab technique training for scientists in developing countries, and $9,950 from the Mozilla Foundation and the Helmsley Trust to develop a phage tracking and phage data publication system.- Completed the NSF-funded I-Corps Accelerator program at University of Georgia to apply lean startup principles to Phage Directory ($3,000 non-dilutive funds).
  • Capsid & Tail: The Phage Community Newsletter
    Founder, Editor, Writer
    Capsid & Tail: The Phage Community Newsletter Oct 2018 - Present
    United States
    Capsid & Tail is a weekly report on bacteriophage news and research (230+ issues published to date), read by 1300+ academics & biotech professionals (40% email open rate). Each week, we highlight phage news and jobs, and publish a blog post on a phage-related topic. Capsid & Tail is also home to a community message board, where the community can list calls for collaborations, highlight events, etc.30% of our blog posts are authored by guest authors (mainly PhD students & research scientists), which I invite & provide editorial support for. I also operate a distributed team of 17 volunteers across 9 time zones who help us with newsletter content & social media.
  • The Westmead Institute For Medical Research
    Postdoc, Phage Manufacturing Lead
    The Westmead Institute For Medical Research Feb 2022 - Mar 2024
    Sydney, New South Wales, Australia
    - Helped establish Phage Australia's personalized, patient-ready phage diagnostics, manufacturing, and quality control system, resulting in $3.5M non-dilutive funding from New South Wales Government in July 2023.- Led production and certification of 17 phage batches approved by local and federal health authorities to be administered IV, topically and via nebulizer to 7 patients (kids and adults) across 3 hospitals through our STAMP clinical trial (one cure to date, others pending).- Implemented comprehensive processes for screening antimicrobial resistant bacterial strains, selecting active phages, manufacturing personalized batches, conducting quality checks, preparing patient-ready aliquots, delivering phages to the patient bedside, and monitoring patients during therapy.- Led the design and implementation of workflows and standard operating procedures (SOPs) for phage sourcing, biobanking, diagnostics, manufacturing, purification, quality control, and therapeutic monitoring.- Coauthored a set of regulatory documents documenting the safety of each phage batch, which gained acceptance from health district drug & ethics committees and were used to establish a standard submission process for each patient.- Acted as the main liaison between the lab and the data engineering & data science team, ensuring the informatics systems aligned with the needs of the lab and clinical settings.- Currently overseeing the transition of our phage manufacturing and quality control processes to a GMP compliant quality management system and cleanroom facility within the Sydney Cell and Gene Therapy center.
  • University Of Georgia
    Visiting Researcher
    University Of Georgia Jan 2016 - Jul 2018
    Complex Carbohydrate Research Centre, Athens, Georgia
    I continued my PhD work here after my advisor accepted a position at University of Georgia. I co-led the move of our lab from Alberta to Georgia & the setting up of our new lab from scratch (ordering & setting up all new equipment, getting projects back up & running).
  • University Of Alberta
    Phd Student / Researcher
    University Of Alberta Sep 2012 - Jun 2018
    Edmonton, Alberta, Canada
    - I studied Campylobacter phage-host interactions, specifically how phages interact with the shape-shifting glycans of Campylobacter. Campylobacter is a difficult organism to culture and genetically manipulate, due to sub-atmospheric oxygen requirements and rapidly shifting genetic code (poly-nucleotide tracts in its genome means ~30 genes randomly toggle on and off every ~1000 divisions). To study it, we would need to make each mutation & genetic complementation multiple times in parallel due to this species' lack of clonality.- I identified a role for host oxidative stress that interfered with phage infection, suggesting previously uncharacterized metabolic requirements for the phage (Sacher et al. 2021, Sacher et al. 2020)- I studied the mechanism of antibacterial activity of a previously uncharacterized phage protein, which we named FlaGrab, with affinity for specific Campylobacter surface glycans (Javed 2015a, Javed 2015b). Through RNASeq transcriptomics I showed that FlaGrab alters metabolic gene expression upon binding, suggesting a physical mechanism triggering cells to shut down key metabolic processes. (Sacher et al. 2020)- I used RNASeq to obtain the first phage+host transcriptome of a lytic C. jejuni phage infection (Sacher et al. 2018)- I co-developed a high-throughput phenotypic screening method for identifying uncharacterized phage receptor binding proteins (Simpson et al. 2015), and adapted it to work in Campylobacter - I identified a conserved DNA modification mechanism in Campylobacter phages, explaining why native phage DNA couldn’t be PCR-amplified or sequenced (Crippen et al. 2019)- I helped elucidate the mechanism of the unexpected antimicrobial effect of cholera toxin on Campylobacter (Patry et al. 2019)
  • University Of Alberta
    Summer Research Assistant
    University Of Alberta May 2012 - Aug 2012
    Phage propagation and titration, characterization of phage receptor binding proteins and their ability to bind host cells following recombinant overexpression.
  • Alberta Glycomics Centre
    Member
    Alberta Glycomics Centre Sep 2012 - Jan 2016
    Alberta, Canada
    The Alberta Glycomics Centre is made up of a multidisciplinary team of researchers studying biological processes and technologies such as carbohydrate synthesis, protein-carbohydrate interactions, glycoengineering, drug discovery, vaccine development, mass spectrometry, and X-ray crystallography, with the goal of a better understanding of carbohydrate science.
  • Highmark Renewables Research
    Intern
    Highmark Renewables Research Jan 2010 - Apr 2010
    Edmonton, Alberta, Canada
    My work involved the study of methane gas production by microorganisms during the process of large-scale waste digestion for the subsequent harnessing of methane as a form of renewable fuel.

Jessica Sacher Skills

Microbiology Phage Biology Molecular Biology Glycobiology Molecular Cloning Western Blotting Protein Purification Biochemistry Cell Biology Microscopy Organic Chemistry Analytical Chemistry Assay Development Cell Biotechnology Polymerase Chain Reaction Science

Jessica Sacher Education Details

Frequently Asked Questions about Jessica Sacher

What company does Jessica Sacher work for?

Jessica Sacher works for Stanford University School Of Medicine

What is Jessica Sacher's role at the current company?

Jessica Sacher's current role is Staff Scientist.

What is Jessica Sacher's email address?

Jessica Sacher's email address is js****@****uga.edu

What schools did Jessica Sacher attend?

Jessica Sacher attended University Of Alberta, University Of Alberta.

What are some of Jessica Sacher's interests?

Jessica Sacher has interest in Social Services, Social Media In Science, Education, Leadership Development, Science And Technology, Ted Talks, Undergraduate Education, Science Outreach, Science Journalism.

What skills is Jessica Sacher known for?

Jessica Sacher has skills like Microbiology, Phage Biology, Molecular Biology, Glycobiology, Molecular Cloning, Western Blotting, Protein Purification, Biochemistry, Cell Biology, Microscopy, Organic Chemistry, Analytical Chemistry.

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