Jessica O'Leary Email & Phone Number

Cambridge, Ma, Us

Providing fractional corporate development, program strategy, and start-up operational support to private early-stage biotech companies. Drive strategy and elevate operations with emerging teams. Pick up the things that fall off the CEO’s plate.

Boston, Ma, Us

76Bio is developing mRNA-LNPs that degrade historically challenging intracellular targets. Member of the leadership team and reporting to the CEO, remit includes business development, program strategy and alliance management, R&D and corporate operations.

Cambridge, Ma, Us

Cambridge, Ma, Us

Lead BD activities to support corporate strategy including but not limited to: 1. Lead search and evaluation triage team and lead individual in-licensing opportunities, 2. Lead out-licensing opportunities (academic collaborations, geographic partnering, broad strategic/transformative partnering), and 3. Support non-dilutive financing activities.BD and AM Accomplishments:• Global strategic collaboration with Biogen for the clinical development and commercialization of zuranolone and SAGE-324. Deal terms include upfront payment of $1.52B, plus up to $1.6B in additional royalties and milestones. • Interim Biogen alliance leader, during which the alliance finalized critical plans for joint US launch responsibilities, brought on new alliance managers, and established new joint governance ways of working.• Strategic collaboration with Shionogi & Co., Ltd., for the clinical development and commercialization of zuranolone in Japan, Taiwan and South Korea. Deal terms include upfront payment of $90M, plus up to $485M in additional royalties and milestones, and option for co-promotion in Japan.• Lead Alliance Management for Sage’s first global partnership; which included the successful completion of Shionogi Phase 1 with SAGE-217, a successful Phase 2, and initiation of Phase 3.• Drove process and criteria for in-licensing new assets, a new competency at Sage, and evaluated over 400 potential assets.

Cambridge, Ma, Us

Cambridge, Ma, Us

Recruited to 30-person company to establish the program management function, within a month of their IPO. My responsibilities included: 1. Manage monthly Portfolio Review Committee meetings – chaired by the CSO and CMO and attended by leadership team, 2. Facilitate cross-functional communication, timely and effective decision-making, and successful execution of program objectives, 3. Identify and communicate interdependencies, critical path activities, risk-mitigation plans, and 4. Lead the Program Management function as it grows into a formal department, including 5 direct reports and 2 indirect.Accomplishments:• Inaugural program management hire – established the processes and ways of working for program teams and portfolio committee.• Established program team structures and subteams to support multiple programs, at multiple stages (from exploratory research to peri-commercial assets).• Tapped to lead critical cross functional teams (ex. IND submissions, NDA submission, BIMO inspection readiness).• Part of the first successful NDA approval of a Sage drug and part of first commercial launch team at Sage, for first approved drug for post-partum depression (Zulresso).

Lawrence Township, Nj, Us

Provided organizational and strategic support for the Molecular Discovery Technologies portfolio by organizing and facilitating monthly portfolio meetings, developing and deploying a Sharepoint portfolio management tool, and project management support. Worked with individual functional teams as well as cross functional networks to identify gaps across the portfolio requiring either scientific guidance and/or resources to achieve program goals. Provided venues for scientific innovation discussions and platform development targeting specific biologics discovery needs. Drove optimization by coordinating best use of resources and tools. Lead simplification projects as they were identified.

Lawrence Township, Nj, Us

In addition to program manager responsibilities for specific therapeutic projects, oversaw Kaizen and Black Belt projects for increased efficiencies and cost savings. Projects were multifunctional and incorporate best practices from Six Sigma and Lean Manufacturing. Projects include reducing the cycle time from hit identification to IND filing, reducing the rework and redundancies in the fermentation process development workstream and streamlining the mouse pharmacokinetic team process.

Lawrence Township, Nj, Us

Recruited to be inaugural program manager on the Adnexus team, to facilitate BMS-Adnexus programs, as well as developing connectivity to the additional biologics acquisitions. My responsibilities emphasize the operational planning and scientific and logistical management of select early and mid stage drug discovery projects, through to early development. This includes meticulous tracking of progress for all internal and outsourced activities that are required to move drug discovery projects forward. Team player with highly evolved organizational, communicative and inter-personal skills, and works closely with the scientific leader to gain cooperation of cross-functional project teams to the early development phase.

Cambridge, Ma, Us

Inaugural project manager for the Ragon Institute, reporting to the director of the institute. Provided project oversight, financial management, and planning support to the six Principal Investigators and other collaborators by facilitating communication across the various sub-teams and by the tracking and reporting of activities to other scientists and the funding foundation. Impact: Maintained oversight of the project with a particular emphasis of meeting deadlines within budget, facilitating collaboration and distribution of information, and identifying issues that may limit the success of the project. Successful first audit by the Gates Foundation and continuation of the following year’s funding.

West Lafayette, In, Us

The Technology Commercialization Laboratory (TCL) at Purdue University pairs MBAs with engineering and life sciences PhDs and professors to effectively translate technology into new products. The TCL has a track record of success in life sciences, medical devices, and nanotechnology.

Marlborough, Ma, Us

Established a means to compile and analyze divisional customers’ product performance needs in relation to the performance attributes of the microfabricated component. Created a “Prioritization Tool” in MS Access that tracks past performance, predicts most valuable future areas of R&D investment, and provides project management capabilities.

Boston, Ma, Us

Ironwood Pharmaceuticals is a public drug discovery company focused on discovering and developing important human therapeutics for unmet needs. Incorporated in 1998, Ironwood has demonstrated clinical success in gastrointestinal and cardiovascular disease.

Cereon Genomics LLC was a collaboration formed between Monsanto and Millennium Pharmaceuticals. Monsanto wholly owned Cereon Genomics LLC and licensed Millennium’s sequencing technology and processes for use in agricultural research.

Cambridge, Ma, Us

Mba, Strategy, Operations

Bs, Biochemistry

Education record