Jessy Matthew Email & Phone Number

Durham, NC

Daily management of clinical trials at Rex Hospital and affiliated physician offices following all applicable GCP/ICH guidelines and FDA regulations.Review of in-house source documents and case reports. Data entry and compilation of IRB documents Source document worksheet review for quality checks, consistency and accuracy

Worked on site selection and study close out tasks. Reviewed regulatory documents and uploaded them to the internal databaseAudited the site documents before study closure and resolved data queriesAllocated subject numbers, added milestone dates, and made subject numbers available to IVRS in e-track, a web based clinical trial management system.

Proposed, developed methods and synthesized small molecule TNF alpha inhibitors and novel muscarinic receptor antagonists.Sunthesized fast followers of LAF-237, a DPP IV inhibitor in phase III trials for type 2 diabetes.

Designed and synthesized a series of highly potent, selective and orally bioavailable NK1 antagonists targeting depression and pain. Identified, synthesized and optimized heterocyclic compounds as Thrombin inhibitors. Conducted SAR studies of lead compounds and contributed to the lead optimization.