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At 1910, I focus on improving our CANDID™ suite of predictive ADMET AI/ML models, primarily for small molecules, and expanding to larger therapeutic modalities. CANDID™ models can expedite the hit to lead and lead to candidate stages of drug discovery. I've practiced machine learning (scikit learn, BERT/NLP, Tensorflow/object detection), data science (python, pandas, MongoDB), and software development (UI/UX, SQL, React, node, CSS), generally in the healthcare and pharmaceutical space, typically in start-ups or similar teams.In addition to my drive and professional experience in software and AI/ML, I've academic experience as a former postdoc scientist/engineer in droplet microfluidics for directed evolution, iPSC to neocortical spheroid differentiation, and MDCK cell culture. My PhD work was in protein expression/purification/thermodynamics, DNA-coated colloid physics/chemistry, fluorescence microscopy, and statistical mechanics (theoretical partition functions/entropy calculations/energy landscapes on graphs). I've mentored undergraduate and high school researchers, and served my colleagues as a lab safety officer and group meeting organizer.In my spare time I've worked on a project in drop-based microfluidics design/maker manufacturing (NSF SBIR project pitch ok'd) and software projects including an Electron prototype exploring the use of writing to recall memories, and one for which a patent was granted. I’ve also enjoyed formulating strawberry flavored alginate and co-leading my son’s former daycare class in making it into drops and gels.
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Ai Research Scientist Iii1910Boston, Ma, Us -
Ai Research Scientist Iii1910 Genetics Dec 2024 - PresentBoston, Ma, UsDeveloping our CANDID™ suite of AI/ML models for ADMET property prediction -
Ai Research Scientist Ii1910 Genetics Jul 2023 - Dec 2024Boston, Ma, Us -
Ai Research Scientist I1910 Genetics Jun 2022 - Jul 2023Boston, Ma, Us -
Ai Research Fellow1910 Genetics Oct 2021 - May 2022Boston, Ma, Us -
Application Developer ICai Sep 2020 - Feb 2021Indianapolis, Indiana, UsReact and React Native -
Software DeveloperBiophilia, Llc May 2020 - Sep 2020ReactJS and nodejs software development for Coactive/CAI.During this time I also completed online coursework in SQL and node-SQL.
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Software Development And MicrofluidicsBiophilia, Llc Apr 2020 - May 2020- Resumed work on a writing therapy nodejs app prototype- Submitted an 'ok'd' project pitch for NSF SBIR/STTR funding in "maker manufacturing"
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Translational ScientistNference Feb 2019 - Apr 2020Cambridge, Massachusetts, Us- trained and tested a binary classifier and BERT-based AI model to infer gene-gene interactions from literature; tools included scikit learn and spacy (NLP)- made a webapp to analyze open source cell line CRISPR dependency map data from the Broad Institute Achilles project; tools included React/Python/MongoDB/Pandas/scipy and nference knowledge graph APIs, statistical measures used the hypergeometric distribution- calculated using HPC methods cosine similarities of cell types and tissue types based on RNA expression vectors across 18,000 genes, similarly cell line CRISPR dependency similarities- client interfacing work included projects with Janssen (J&J) and Syngenta, calculated PCA (Principle Component Analysis) plots for the latter NLP project -
PostdocWeitz Lab, Harvard Seas/Physics Aug 2016 - Aug 2018I make microfluidic junctions in a clear rubber (PDMS), and use them to make collagen drops containing neocortical progenitor stem cell spheroids (human iPSC-derived). The collagen gels around the cells to cue their differentiation to neurons. The resulting brain organoids could be used for studying basic (ie, "where are memories located?") and applied (ie, screening drugs against alzheimer's phenotypes) questions in neuroscience. With our dropmaking devices, we make hundreds of collagen drops per minute, about 100 times faster than when the gels are made by hand pipettor.
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PostdocTyo Lab At Northwestern And Weitz Lab At Harvard Aug 2015 - Aug 2016High throughput assay development for directed evolution of polymerases in microfluidic drops for neuroscience applications.- via a dilution series, proved we could detect drops containing a single molecule of polymerase DNA- worked with in vitro transcription and translation reagents, and a GFP reporter assay- screened drops at .2 khz rates
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Scientific Writing; Software Planning, Development, And DistributionStarlink, Llc Jun 2014 - Jul 2015During this time I worked on converting 2 chapters from my thesis into journal articles, on software projects with friends/family and colleagues (see projects), and on looking for jobs in industry and science.
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Phd, Harvard School Of Engineering And Applied SciencesManoharan Lab, Harvard University Sep 2006 - May 2014Cambridge, Massachusetts, UsWhat if, after gently shaking a box of jigsaw puzzle pieces, you found the puzzle had completed itself? I studied analogous systems: proteins and DNA-coated microspheres. The point was to understand the physics of biological molecules. How do proteins fold and organize? How does life as we know it emerge from the seemingly random motion of petite, perhaps purposeful parcels of matter?After first studying a protein, Dscam, we turned to DNA-coated microspheres, an experimental system that circumvented a few problems with studying proteins directly. Individual proteins are too small and fast to see well, but microspheres are large and slow enough to watch with an optical microscope. Proteins are also very complex, consisting of a large number of different amino acids, whose interactions are not fully understood nor controllable. We studied small numbers of microspheres, so we could make sense of all the different clusters they could possibly form. We controlled the interactions between microspheres by controlling the DNA sequences on them. Although proteins and DNA-coated microspheres are thus very different, we believe that proteins and microspheres are obey similar physics. Statistical mechanics can be applied to both systems.In these thesis experiments, we found that with careful control of the interactions between the building blocks, uncommonly symmetric structures self-assemble. Link to my thesis: https://dash.harvard.edu/handle/1/12274201 -
Teaching Fellow, Ps2 - Physics For Life SciencesManoharan Lab, Harvard University Sep 2008 - Dec 2008Cambridge, Massachusetts, UsCo-developed lesson plans, graded quizzes and homeworkLead section for 20 studentsCo-administered homework help session for up to about 50 students at a timeCoursework including the following subjects: kinematics, acceleration, friction, force balances, torque, energy conservation -
Tutor, 8.03 - Waves And VibrationsMassachusetts Institute Of Technology (Mit) Feb 2006 - Jun 2006Cambridge, Ma, UsHeld office hours to help students individually and in small groups -
Undergraduate Researcher (Urop) - Pat Doyle GroupDoyle Lab Mit 2005 - 2006Formulated a UV curable ferrofluid, optimized continuous droplet polymerization flow rates, made PDMS microfluidic devices, demonstrated “janus” microparticle polymerization via laminar coflowPerformed microscopy of microparticles and collaborated on a journal article (see publications)
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Undergraduate Researcher (Urop) - Marc Kastner GroupMassachusetts Institute Of Technology (Mit) Jun 2004 - Sep 2004Cambridge, Ma, UsMade SQUID (super-conducting quantum interference device) and ESR (electron spin resonance)measurements of colloidal CdSe quantum dots down to 4K, found an ESR peak at 39K. -
Summer InternMarypaul Laboratories Inc Jun 2003 - Sep 2003Tested local water samples for presence of microorganisms, mixed media, cleaned and sterilized glassware.
Jesse W. Collins, Ph.D. Skills
Jesse W. Collins, Ph.D. Education Details
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Harvard UniversityApplied Physics -
Harvard UniversityApplied Physics -
Massachusetts Institute Of TechnologyPhysics -
Massachusetts Institute Of TechnologyLiterature -
Sparta High School -
Massachusetts Institute Of Technology -
Massachusetts Institute Of Technology
Frequently Asked Questions about Jesse W. Collins, Ph.D.
What company does Jesse W. Collins, Ph.D. work for?
Jesse W. Collins, Ph.D. works for 1910
What is Jesse W. Collins, Ph.D.'s role at the current company?
Jesse W. Collins, Ph.D.'s current role is AI Research Scientist III.
What is Jesse W. Collins, Ph.D.'s email address?
Jesse W. Collins, Ph.D.'s email address is je****@****ail.com
What is Jesse W. Collins, Ph.D.'s direct phone number?
Jesse W. Collins, Ph.D.'s direct phone number is (617) 253*****
What schools did Jesse W. Collins, Ph.D. attend?
Jesse W. Collins, Ph.D. attended Harvard University, Harvard University, Massachusetts Institute Of Technology, Massachusetts Institute Of Technology, Sparta High School, Massachusetts Institute Of Technology, Massachusetts Institute Of Technology.
What are some of Jesse W. Collins, Ph.D.'s interests?
Jesse W. Collins, Ph.D. has interest in Social Services, Children, Mobile, Clean Technology, Economic Empowerment, Civil Rights And Social Action, Education, Environment, Health Care, Poverty Alleviation.
What skills is Jesse W. Collins, Ph.D. known for?
Jesse W. Collins, Ph.D. has skills like Physics, Research, Nanotechnology, Fluorescence Microscopy, Science, Data Analysis, Microscopy, Experimentation, Materials Science, Microfluidics, Spectroscopy, Statistics.
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