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Adaptable, hands on, wet synthetic chemist with 25+ years’ experience in drug discovery / drug delivery. Principal strengths include solution-phase synthesis and instrumentation analysis of lipid compounds and heterocyclic/small-molecule inhibitors. Working knowledge and expertise in:• Bruker , Jeol & Varian 400 MHz NMR Systems, 1H & 13C • LC/MS, Analytical (SQD, Xevo QTof) & Preparatory (ZQ Prep) systems • MPLC Purification Systems (Grace, ISCO & Yamazen) • UPLC/HPLC, Analytical & Preparatory• FTIR & UV/VIS Spectroscopy• Biotage Microwave Reactors • Thin-Layer Chromatography (TLC)• Waters MassLynx, ProMass & Open Access software• Thales H-Cube • MS Office & ChemDraw Pro• eDM Systems • CAS SciFinderI am currently working with Nitto BioPharma Inc. (NBPI) preparing various lipids that are utilized in different LNP drug delivery vehicles for xRNA payloads. Other duties include SCM coordinator for cGMP excipients & lipid raw materials for Clinical DP manufacturing.Previously at Nitto Denko Technical (NDT) Corp's Fibrosis group, I performed lipid & Vitamin A conjugate synthesis that were utilized in a liposomal drug delivery vehicle of a siRNA payload for targeted Liver Fibrosis.Before NDT I was with Tanabe Research Laboratories (TRL) Med Chem Department. My primary responsibility was planning/performing multi-step synthesis of small-molecule inhibitors from mg to multi-gram scale for numerous projects. My secondary responsibility was to maintain, trouble shoot and provide training on multiple LCMS & UPLC systems. Prior to TRL, I worked for Corvas International Incorporated. Once again, my primary responsibility was the design and synthesis of peptides, peptidomimetics and small organic molecule inhibitors in collaboration with senior scientific staff. This included both solution-phase and solid-phase methods. Other experience include working at an Environmental Testing Lab, Analytical Technologies Incorporated. Working independently, my primary responsibility was the preparation of samples for analysis. I did liquid-liquid and solid-liquid extractions for pesticides, herbicides, PCB’s, fuel and volatile samples. All extractions followed GLP & EPA method guidelines.
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Staff ScientistNitto Biopharma Inc Feb 2016 - PresentNitto BioPharma’s mission is to develop and deliver innovative life-transforming therapies for patients with unmet medical needs.• Synthetic chemist producing cationic, ionizable, PEG and helper lipids that are utilized in LNP drug delivery vehicles for xRNA payloads. • SCM coordinator for cGMP excipients & lipid raw materials for Clinical DP manufacturing• Directly Responsible Individual (DRI) for cGMP chemistry lipid efforts at CMOs, including initiating contact with potentially new CMOs in order to seek both non-GMP & cGMP bids. Authored request for proposals (RFPs) and coordinated tech transfers.
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Lipid Synthesis - Senior Scientist IiNitto Denko Oct 2010 - PresentTeaneck, Nj, UsNitto Denko Technical Corporation (NDT) was established as an independent centre of excellence for research and development into new growth engines for its parent company, Nitto Denko Corporation based in Osaka, Japan. * Performing Lipid Synthesis to supply Formulation Department with required cationic, ionizable, PEG and permanently-charged lipids along with Vitamin A conjugates that are utilized in a liposomal drug delivery vehicle of a siRNA payload for targeted Liver Fibrosis.* Aided in the drafting/editing of two provisional chemistry patents.* Drafted synthetic protocol for a tech transfer of a Vitamin A conjugate for CRO.* Maintenance & operation of a Waters UPLC-Xevo G2 QTof & UPLC-SQD systems -
Senior Research AssociateTanabe Research Laboratories U.S.A. Inc Sep 2002 - Feb 2010Carlsbad, Ca, UsSubsidiary of Mitsubishi Tanabe Pharma Corp. Ltd., in discovering, optimizing and developing innovative pharmaceutical products to address unmet medical needs in major therapeutic categories.* Performed Milli/multi-gram scale multi-step organic synthesis, purification and characterization of various Kinase, GPCR, Chemokine and Nuclear Receptor inhibitors designed by senior staff and myself.* Illustrated chemistry progress to senior scientific staff in written reports and in oral presentations/discussions. This included (but not limited to) written monthly reports, chemistry meeting presentations, journal club presentations and yearly research management presentations.* Maintained, configured, and trouble-shot Waters MassLynx LCMS & UPLC analytical and preparative instruments. Drafted all SOP's on instrument usage and trained colleagues on instrument operation.* Performed HTS hit compound screening for structure validation and compound purity checks. * Performed liquid nitrogen and helium cryogen fills along with schedule preventive & emergency maintenance on a Bruker 400 MHz NMR. -
Associate Scientist IiCorvas International, Inc May 1996 - Aug 2002Biopharmaceutical Company focused on the discovery and development of novel therapeutics.* Executed large and small-scale multi-step organic synthesis in collaboration with senior scientific staff.* Purified and characterized novel organic compounds for in-vitro/in-vivo evaluation.* Resynthesized multi-gram quantities of high interest compounds and commonly used intermediates required for various programs.* Maintained records in laboratory notebooks along with oral/written reports to summarize laboratory activities.* Responsible for ordering, maintaining and updating the chemical inventory of the laboratory along with cryogen fills of Varian 400 MHz NMR.
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Chemist IAnalytical Technologies Inc Jan 1994 - Dec 1995Environmental Testing Laboratory* Extracted pesticides, herbicides, and PCB’s from water and soil samples for analysis.* Followed EPA & GLP method guidelines for all extractions.* Entered data into the computer system for quality control department.
John Gaudette Education Details
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Uc San DiegoChemistry
Frequently Asked Questions about John Gaudette
What company does John Gaudette work for?
John Gaudette works for Nitto Denko
What is John Gaudette's role at the current company?
John Gaudette's current role is Staff Scientist at Nitto BioPharma Inc.
What is John Gaudette's email address?
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What is John Gaudette's direct phone number?
John Gaudette's direct phone number is +161986*****
What schools did John Gaudette attend?
John Gaudette attended Uc San Diego.
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