Jhuma Das, Ph.D. Email & Phone Number

Carlsbad, Ca, Us

Cambridge , Ma, Us

Cambridge, Massachusetts, Us

My life long passion to serve the life sciences research community to address unmet human health related needs by generating predictive structural models, and identifying drug targets, potential biomarkers (for diagnostic purposes), and biomolecules (for therapeutic purposes) using state-of-the-art computational methods. By de-convoluting information-rich, complex data sets derived from experiments, I design predictive models to find trends and patterns that ultimately can serve as diagnostic tool and/or guide rational drug design. My skills include (and not limited to) computational modeling, molecular simulations, computer progamming and bioinformatics.

Chapel Hill, Nc, Us

• Young investigator Pilot and Feasibility Grant Award from Cystic Fibrosis Foundation• Combining cutting-edge experimental-computational technique to model mucin structures and study their structure-function relationship to aid rational pharmacological campaigns for respiratory diseases (e.g., Asthma, CF, COPD) in a joint effort comprising cross-functional team of biochemists, molecular biologists, and medical doctors• Studying the dynamics of normal versus pathological cystic fibrosis transmembrane regulator (CFTR) channel for finding the origin of Cystic Fibrosis

Chapel Hill, Nc, Us

•• Initiated, led and managed 8 successful computational modeling, protein design and drug discovery-based projects in fatal human disorders with drug targets CFTR, AMPK, ApoE in collaboration with team of physicists, chemists, biochemists and through training graduate and undergraduate students• Published 9 peer-reviewed papers in high-esteemed journals and 1 manuscript under review• Joint co-author and recipient of 10 million CPU hour allocations through successful grant proposals (Director’s Discretionary Program of Oak Ridge Leadership Computing Facility and Argonne National Laboratory, USA)

Chapel Hill, Nc, Us

• Developed atomistic, coarse-grained and lattice models for charged surfactant coated surfaces using Monte Carlo and Molecular Dynamics simulations for designing optimal drug delivery vehicle

Durham, North Carolina, Us

• Successfully completed Contract with Parion Sciences Inc. in the development of ligand-based predictive models to design novel therapeutic compounds via Quantitative Structure-Activity Relationships (QSAR) of investigational drugs

Durham, North Carolina, Us

• Led and managed contract-based data-driven drug screening campaign to identify hits for Cystic Fibrosis via combined in silico-experimental strategies in collaboration with Parion Sciences Inc. • Generated and interpreted data and written computational section of the grant, which resulted in direct determinant of receipt of $1.7 million grant by Parion Sciences, Inc. from Cystic Fibrosis Foundation Therapeutics, Inc. based on conducted collaborative research

Columbia, Mo, Us

• Modeled, simulated and analyzed lipid, protein and water dynamics in biomolecular systems using integrated computational-experimental approaches• Taught and managed over 60 under-graduate students per semester for 4+ years through weekly Physics lab and problem solving classes

Kolkata, West Bengal, In

• Analyzed crystal structure databases to identify non-canonical base pairs and higher order structures in RNA, resulted in 1 publication; Built, managed and shared data on a web server

Phd, Physics

Masters, Physics