Jia-Ying John Y. Email & Phone Number

1. Collaborate with CRO for the PK/safety study, which supports the IND application for iDose in US clinical trial.2. Establish bench top in vitro assay for in house compound analysis.

Irvine, Ca

1. Non-invasive electroretinography(ERG) and ocular imaging investigation of retinal degeneration in knockout mice model supporting target selection.2. Development of a retinal degeneration model for compound assessment through electrophysiological endpoints (ERG and visual evoked potential (VEP))3. In vivo compound specificity and neural transmission pathway evaluation utilizing receptor null animals.

Irvine

1. Conducted mouse behavior studies supporting in-vivo compound screening of neuro-enhancement compounds.2. Established and refine electrophysiology endpoints allowing isolation of inner retina functional activity (scotopic threshold response (STR)). 3. Conducted pharmacokinetic studies, dosing and tissue collection.4. High-throughput compound screening.

Irvine, Ca

1. Investigate insulin-induced Akt1/2 translocation to mitochondria in wild type, Akt1/2 knockout and diabetic myocardium, and it's effect on mitochondrial function. 2. Investigate gene expression profile and mitochondrial abundance changes in mouse embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC).

Irvine, Ca

1. Discover the novel signaling pathway of insulin induced-Akt translocation to mitochondria in myocardium, and its implication on mitochondrial function in insulin deficient or resistant diabetic myocardium.2. Investigate the phenotypes from cbl-associated protein (CAP) knocked out mice, including glucose tolerance test, insulin tolerance test and histological study.  3. Build a myocardium-specific, tet on/off controlled heat shock protein 60 (hsp60) overexpression mouse line..Publications:1. Yang JY, Deng W, Chen Y, Fan W, Baldwin KM, Jope RS, Wallace DC, Wang PH. Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. J Mol Cell Cardiol. 2013 Jun;59: p167-175.2. Yang JY, Yeh HY, Lin K and Wang PH. Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium. J Mol Cell Cardiol. 2009 Jun;46(6):p919-926.3. Lai HC, Liu TJ, Ting CT, Yang JY, Huang L, Wallace D, Kaiser P and Wang PH. Regulation of IGF-1 receptor signaling in diabetic cardiac muscle: dysregulation of cytosolic and mitochondria HSP60. Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E292-297.4. Chen HS, Jia J, Su HF, Lin HD, Chenc JW, Lin SJ, Yang JY, Lai HC, Mestril R and Wang PH. Downregulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency. J Endocrinol. 2006 Aug;190(2):433-440.

Lecture in Biochemistry Lab. Also held a section for student who had questions in Biochemistry lecture.

Irvine

1. In vitro photodynamic injury model (retinal pigment epithelial cell and choroidal endothelial cell) to assess compound efficacy and in vitro treatment condition. 2. Assess the retinal and choroidal blood flow change in photodynamic injured rabbit and monkey.3. Elecrtrophysiological(ERG) assessment of neuroprotective compounds on acute-elevation of intra-ocular pressure (IOP) in rabbit.

Taipei City, Taiwan

Investigated the monoclonality in NK/T cell in sinonasal lymphoma- determine the length polymorphism in T cell receptor rearrangement (TCR) and in killer immunoglobulin-like receptor (KIR) V-J junction region.Publications:1. Lin CW, Yang JY, Chuang YC, Chen YH, Albitar M, Hsu SM. Presence of restricted killer immunoglobulin-like receptor repertoire and monoclonal T-cell receptor gamma rearrangement as evidence of mixed NK/T-cell differentiation in a subset of sinonasal lymphomas. Lab Invest. 2003 Jan;83(1):55-64.2. Lin CW, Lee WH, Chang CL, Yang JY, Hsu SM. Restricted killer cell immunoglobulin-like receptor repertoire without T-cell receptor gamma rearrangement supports a true natural killer-cell lineage in a subset of sinonasal lymphomas. Am J Pathol. 2001 Nov;159(5):1671-9.

Taipei City, Taiwan

Investigated rat primary microglia cell in response to cytokines and beta-amyloid peptides, which plays an important role in the pathogenesis of Alzheimer's disease.

Executed Anti-smuggling mission along the coastline of Taoyuan county.

Investigated the relationship between apo-E genotypes and homocystein concentration in serum from hypertension patients.Skills: HPLC (reverse phase), apo-E genotyping, RFLP

Investigated the relationship between apo-E genotypes and homocystein concentration in serum from hypertension patients.

Ph.D, Experimental Pathology And Laboratory Medicine

M.S., Biotechnology

M.S, Life Science

Dissertation: Analysis of allelic association between monoamine oxidase (MAO) and the level of MAO metabolite from human blood sample.

Bs, Food Science

Activities and Societies: Relationship of plasmids and resistance of antibiotics in Staphylococcus aureus. Men's Volleyball Team