Jignesh Nagar, M.Pharm, Felasa-C Email & Phone Number

Bengaluru, Karnataka, India

Exploring new therapeutic indications like COPD/systemic sclerosis/lung fibrosis and colitis by using cutting edge latest technological platforms for instance µCT Imaging, Oxymetry, Flexivent, and many more. Validation and POC of immunological therapeutic targets, development of an acute and chronic murine model for various programs.

Ahmedabad, Gujarat, India

• BA/BE and Phase-I studies; Preparation of protocol, CRF, ICD, report, SOP, submission of documents to CDSCO/IEC• Feasibility check, study protocol, inclusion/exclusion criteria, %ISCV, Cmax, Tmax, AUC, cross-over, partial & full replicate design• Ensure Investigational medicinal products are stored, safe for human use, dispensed, and used safely and correctly for the subjects• Responsible for study tracking, monitoring, study schedule, subject check-in/check-out, achieving the study milestone • Involved in pre-study initiation/close-out meeting, assisted in the regulatory filing of USFDA, EMA, EU, ANVISA, DCGI

Mumbai, Maharashtra, India

 Efficiently worked as a Product manager and developed various formulation Standardized several anti-malarial formulations in close collaboration with south African company Optimised long-acting injectable combination of atovaquone and proguanil to treat the malaria Outsource the pharmacokinetic, toxicity (single dose and multiple dose) studies in rat and mice Development of various formulation to support the internal programs i.e. sucralfate for acidity

India

I have innovative and entrepreneurial mindset, as illustrated by contribution to diverse therapeutic indication reserach projects in highly collaborative cultures, as well as signigficant contribution in preclinical research and screened hundreds of new chemical entities from several programs to strenthen the drug discovery protfolio.I am organized and detail oriented researcher, experience in in-vivo pharmacology with strong data analysis and problem solving skills, resulting in the development of a new optmized method of various rodent model as well as I have been steering force behind the development of an animals model for inflammation as well as autoimmune disorder. I have excellent project managment skill and capacity to provide technical support demonstrated by conceptualization and completion of various immunology program and collaborative projects. Having worked in fast-paced, dynamic environment, my contribution to collaborative reserach have included screening of novel drug entities in various therapeutic indication like Inflammatory Bowel disease, Rheumatoid arthritis, Systemic sclerosis, Systemic lupus erythematosus, Immuno-oncology, Cardiovasculer as well as Multiple sclerosis program.I have gained strong communication and scientific writing skills, resulting in the publication of nine scientific articles internationally and awarded more than 18 prestigiuos award in my tenure including Bravo, Star, Cap as well as Triumph award. I am also a Federation of European Laboratory Animals Scientist Association (FELASA-C) certified Laboratory Animal Scientist.

Bengaluru South, Karnataka, India

 Certified as a CLAS-Certified Laboratory Animal Scientist by FELASA –C (European Association) Ethically conducted research work in rodents based on AAALACi/CPCSEA/IAEC guidelines Having sound and in-depth knowledge of Pharmacology, Pharmacokinetics, Toxicology, PKPD, Bioequivalence, and Clinical trials Followed the dynamic research from the therapeutic target identification, SWOT analysis, validation, and Proof of Concept (POC) Interaction with scientific experts in the field of immuno-science, Fibrosis, and Immuno-cardi-vascular (ICV) for the BMS portfolio. Method development for the estimation of soluble collagen, hydroxyproline in skin and lungs, ELISA for different cytokines/chemokines, autoantibodies titer estimation like dsDNA, IgG, IgM, and anti-collagen antibodies Handling the pulse oximetry and Flexi-vent instruments for the measurement of lung function parameters in mice Identification and analysis of immune complex deposition in kidney and brain by Immunofluorescence techniques using cryosection as well as Immuno Histo-Chemistry techniques in paraffin-embedded section.

Bengaluru South, Karnataka, India

Interaction with Biostatisticians while planning the preclinical studies, protocol writing, protocol preparation, and analysis of data in terms of statistical significance Software and Instruments proficiency like Graph-pad PRISM, Windows 10, MS Office 2019, Adobe Photoshop, Lab Track, Electronic Laboratory Notebook, various scientific databases surfing and literature search, Plethysmometer, Planter analgesiometer, Cryo-section: Leica/Thermo, Softmax pro, and NIS, Fluorescence microscope. Preparation and presentation of Animal Testing Methods (ATMs)/study protocols, amendment, and extension of animal protocols to Indian regulatory authorities like CPCSEA/IAEC. Successfully received full accreditation from AAALACi for vivarium. Awarded for the implementation of Lab Track Software for efficient animal usage and Implementing 3R (Reduce, Refine, and Replace) in animal experiments. Maintenance of the animal-related regulatory documentation Analysing the translational approach by discussing with the clinical development team and preclinical programs support team Having strong interpersonal, analytical, and decision-making skills Handling multiple therapeutic programs simultaneously and performing the strategic evaluation of the project Attending DWG, strategies, telecom, videoconference, and veterinary science meetings for the different programs Identifying the blood/urine biomarker for the Translational Research & Development (T-R&D) Frequently presented scientific literature in team meetings related to arthritis, IBD, lupus, systemic sclerosis, and asthma Assisted in organizing scientific advisory committee (SAC) meetings and scientific journal club. Co-ordinate with third parties for the outsourced studies to ensure the timely completion of preclinical projects. Imparted training to recruits and biotechnology/life sciences graduates in various areas of pre-clinical drug development

Bengaluru South, Karnataka, India

 Cryo-sectioning of mice kidney and brain, Identification of immune complex deposition by Immunofluorescence techniques. Microscopy for measurement of intensity and number of immune complex deposition by NIS software. Performing the Immuno Histo Chemistry (IHC) for the immune cell infiltration in the kidney. Possess good skills for data analysis, data interpretation, and documentation of Protocol, Report, SOP, and CTD for the IND filing. Developed own desirable project ideas and supported ongoing projects in different stages Worked with US-based BMS scientists and research associates, developed and maintained a culture of teamwork and collaboration Having interpersonal, analytical, troubleshooting, and decision-making skills while performing simultaneous multiple studies.International PublicationsAwardsSeminar ConferencesAcolades

Ahmedabad, India

Handling Small Laboratory Animal, Screening of NCEs in Animal Models, development and standerdization of animals models for variuos therapeutic indication for instances IBD, RA, LUPUS and Systemic sclerosis. Aniamls care techinician as well as animal health technician.

Master In Pharmacy, Pharmcology, 72% (Gpa : 3.27/4)

Studied variuos subjects related to Pharmacology, ADME, Animal model development, cell biology, receptor engagment, immunology.

Bachelor Of Pharmacy - Bpharm, Pharmacy And Pharmacology, 68% (Gpa : 3.35/4)

Various Pharmacy subject