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As a seasoned executive with over 20 years of experience in the biotech industry, I have a proven track record of driving drug discovery from target identification to IND clearance and a passion to bring effective new medicines to patients. I bring a wealth of experience in leading and advancing groundbreaking research initiatives. Throughout my career, I have successfully managed and mentored dynamic teams, spearheading strategic projects in inflammation, oncology, platform technologies, and pioneering novel modalities. My expertise lies in seamlessly integrating drug discovery technologies, fostering collaboration between diverse scientific teams, and driving key initiatives from concept to fruition.I am passionate about pushing the boundaries of scientific discovery and contributing to transformative breakthroughs in the field. I have co-authored publications in prestigious journals and co-invented multiple patents. My commitment to innovation, coupled with executive-level communication and effective leadership, has played a pivotal role in achieving acquisition milestones and aligning organizational goals.I am driven by a desire to make a lasting impact on the biotech landscape and to apply my expertise and creativity to advance the field of drug discovery and deliver innovative therapies for unmet medical needs. I am excited about connecting with like-minded professionals who share a vision for advancing the frontiers of science. Executive Strengths/Key Skills:Platform Technology Management ✧ Oncology Program Advancement ✧ Computational Team Collaboration ✧ Biotechnology Industry Acumen ✧ Strategic Initiatives Execution ✧ Early Research Contribution ✧ Research Team Leadership ✧ Innovation Mentoring ✧ Proof-of-Concept Funding ✧ Modality Initiative Spearheading ✧ Scientific Advisory Board Development ✧ Public Speaking/Presentations ✧ Executive Level Communication ✧ Acquisition Milestone Achievement ✧ Organizational Goal Alignment
Flagship Pioneering
View- Website:
- flagshippioneering.com
- Employees:
- 772
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Svp, Head Of ResearchFlagship PioneeringBoston, Ma, Us
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Svp, Head Of Drug DiscoveryVantai Apr 2024 - PresentNew York, Ny, Us -
Vp, Discovery TechnologiesRelay Therapeutics Apr 2021 - Apr 2024Cambridge, Ma, UsAs VP of Discovery Technologies at Relay Therapeutics, I led a team of scientists who leverage machine learning and high-throughput selection technologies to discover novel small molecule drugs for challenging targets. I orchestrated the seamless integration of the ZebiAI team into existing organization at Relay. My efforts significantly enhanced collaboration and contributed to multiple research initiatives. My role extended to actively collaborating with the computation team, leading to breakthroughs in machine learning approaches. I successfully met post-acquisition milestones, demonstrating a track record of aligning with organizational objectives and recognizing value for shareholders. -
Svp, Head Of Drug DiscoveryZebiai Therapeutics May 2020 - Apr 2021As the Vice President and Head of Drug Discovery at ZebiAI Therapeutics, I led diligence discussions resulting in the acquisition by Relay Therapeutics for $85 million upfront. My leadership extended to building and leading teams in protein science, medicinal chemistry, and platform technology. I pioneered a machine learning-based drug discovery strategy in collaboration with Google Accelerated Science, X-Chem, and the Structural Genomics Consortium. Actively advancing internal oncology programs, I identified novel binders for undrugged targets using machine learning models, contributing to the success and growth of the organization.
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Vice President, BiologyX-Chem, Inc. Mar 2016 - May 2020Waltham, Ma, UsIn my role as Vice President at X-Chem Pharmaceuticals, I played a pivotal role in building and expanding the internal drug discovery team. This involved overseeing protein biochemistry, cell biology, structural biology and medicinal/computational chemistry functions. I drove the pursuit of internal projects and collaborated on inflammation, immunotherapy, and infectious disease initiatives that resulted in partnerships with leading academic institutions. My leadership led to the spin-off of new companies and the progression of a molecule to Investigational New Drug (IND) status, showcasing a commitment to optimizing drug discovery for clinical success. -
Sr. Director, Biochemistry And Cell BiologyX-Chem, Inc. Dec 2010 - Mar 2016Waltham, Ma, Us
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Director, BiologySyndexa Pharmaceuticals Nov 2009 - Dec 2010UsDirected interdisciplinary teams in biology and chemistry, propelling diabetes drug discovery programs. Developed a groundbreaking discovery strategy for JNK kinase, leading to the identification of a potent lead series with a novel binding mode for obesity-related disorders. Established a phenotypic assay targeting endoplasmic reticulum stress associated with Type 2 Diabetes. -
Director, Elt Lead DiscoveryGlaxosmithkline Dec 2006 - Nov 2009Brentford, Middlesex, GbManaged a dynamic team driving drug discovery across various therapeutic areas, including Inflammation, Metabolic Diseases, Oncology, Neurosciences, and Infectious Disease. Led collaborations with prestigious institutions such as Harvard University, University College London, and Sirtris. Chaired the Encoded Library Target Portfolio Team, overseeing the progress of multiple targets. -
Principal Scientist, Cell And Molecular TechnologiesPraecis Pharmaceuticals Apr 2005 - Dec 2006UsSuccessfully led a discovery collaboration with GSK, resulting in the acquisition of Praecis by GSK. Identified a small molecule series for epoxide hydrolase, advancing into clinical trials. Co-authored a seminal paper on DNA-encoded library screening for hit identification. Established and directed drug discovery strategies for multiple oncology programs. -
Principal Research Scientist, Inflammation SignalingWyeth Sep 2000 - Apr 2005New York, New York, UsLed the TPL2/Cot kinase project, identifying the first potent inhibitors with efficacy in animal models of TNFα production and human arthritic tissue. Initiated and led the IRAK4 program. Established quantitative assays for analyzing signaling pathways triggered by inflammation in primary human monocytes, human whole blood, and animal tissues. -
Postdoctoral Research In BiologyMit 1997 - 2000Cambridge, Ma, UsUsed the power of yeast genetics combined with biochemical analysis to identify multiple components of disulfide bond formation pathways in the endoplasmic reticulum.
John Cuozzo Skills
John Cuozzo Education Details
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Tufts University School Of MedicineCellular And Molecular Physiology -
Boston UniversityArchaeology
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Brown UniversityBiophysics
Frequently Asked Questions about John Cuozzo
What company does John Cuozzo work for?
John Cuozzo works for Flagship Pioneering
What is John Cuozzo's role at the current company?
John Cuozzo's current role is SVP, Head of Research.
What is John Cuozzo's email address?
John Cuozzo's email address is jw****@****zon.net
What is John Cuozzo's direct phone number?
John Cuozzo's direct phone number is +150825*****
What schools did John Cuozzo attend?
John Cuozzo attended Tufts University School Of Medicine, Boston University, Brown University.
What are some of John Cuozzo's interests?
John Cuozzo has interest in Kids, Cooking, Exercise, Investing, Outdoors, Sweepstakes, Electronics, Home Improvement, Reading, Crafts.
What skills is John Cuozzo known for?
John Cuozzo has skills like Drug Discovery, Assay Development, Biochemistry, Protein Chemistry, Cell Biology, Biotechnology, Protein Expression, Molecular Biology, High Throughput Screening, Life Sciences, Lifesciences, Drug Development.
Who are John Cuozzo's colleagues?
John Cuozzo's colleagues are Laura Maiorino, Anneka Pryce, Ronny Straube, Vinidhra Mani, Lynne Mcevoy, Karl Biggs, Jennifer D..
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