Jerry O'Dwyer Email & Phone Number

Williamsburg, Va

In fulfillment of the Honors Bachelor's Degree in Biology, this thesis focusses on subcellular localizations of thyroid hormone receptors and their associated cancer and Resistance to Thyroid Hormone Syndrome (RTH) mutations. An emphasis will be placed on biochemical and computational analysis.Part 1: Nuclear Localization of Thyroid Hormone Receptor Alpha 1 (TRa1)Part 2: Protein Modeling of Oncogenic and RTH MutationsPart 3: Calcium signaling, hypercalcemia, and the effects on localizationPart 4: Molecular Dynamics (MD) simulation and TR Stabilizing Drug Analog

Williamsburg, Va

HHMI undergraduate researcher focussing on nuclear trafficking of thyroid hormone. Prior experiences include bacterial transformation, plasmid preparation and sub cloning, working with cell culture, transfections, epifluorescence microscopy, co-immunoprecipritate, and Western Blot.

Providence, Rhode Island Area

Research internship at Brown Orthopedic Department under the supervision of Dr. Qian Chen and Dr. Yun Gao. My research focused on nucleoside reverse transcriptase inhibitors (NRTIs) and their effects on join health (including trabecular bone morphometry, cartilage health, and other hypertrophic markers of osteoarthritis (OA) such a ColX and Mmp13). Prior experiences obtained include the following: genotyping, thermocycler PCR, Southern Blot, RNA isolation, RT-qPCR, Sonication Protocol and operation, Methylated DNA immunoprecipitation, qPCR, Safranin-O staining, Immunohistochemistry, and MicroCT operation and analysisKnowledge obtained: Understanding of joint health (including the progression of osteoarthritis and osteoporosis)

Doctor Of Philosophy - Phd

Bachelor'S Degree

Exchange Program

Education record