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Board-certified Toxicologist with a diverse background encompassing more than 10 years of experience in the field. Experienced in preparing relevant sections of INDs/CTAs, IBs, and marketing authorizations for submission to the FDA and ex-US regulatory agencies. Responsible for the development, oversight, and management of nonclinical GLP and non-GLP studies, including investigational, FIH-enabling, DART, and CARC studies. Demonstrated performance working as an individual as well as part of a cross-functional team to deliver therapies to patients.For a complete list of 21 peer-reviewed manuscripts/book chapters, see http://www.ncbi.nlm.nih.gov/pubmed/?term=cichocki+ja
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Toxicology Research Fellow IVertex Pharmaceuticals Apr 2020 - PresentBoston, Ma, UsProject team toxicologist (Regulatory Tox)
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Senior Scientist/Scientist, ToxicologyAlnylam Pharmaceuticals Apr 2017 - Mar 2020Cambridge, Massachusetts, UsServed as a Nonclinical Representative for multiple Program Teams spanning diverse therapeutic areas (hepatic infectious disease, genetic medicine)Designed, conductededd, and interpret GLP toxicology studies, including CTA/IND-enabling studiesInteract with CROs and serve as the Sponsor Representative on GLP tox studiesContribute to the development of a nonclinical drug development strategy for a novel class of therapeutics (conjugated siRNAs)Conducted in-house investigational toxicology studies to support development of lead candidatesAuthored nonclinical sections of various regulatory documents including IBs and CTA/INDsUtilized statistical software, including R, to compile and analyze nonclinical safety assessment of conjugated-siRNA compounds. These novel findings were presented at the Northeast Society of Toxicology Annual Meeting in 2017. -
Niehs Nrsa Postdoctoral FellowTexas A&M University Sep 2015 - Apr 2017College Station, Tx, UsThe goal of this project is to investigate the potential contribution of underlying liver disease to interindividual variability in susceptibility to the adverse health effects associated with exposure to environmental chemicals. Specifically, I will study the relationship between tetrachloroethylene toxicokinetics and tissue-specific toxicodynamics in both healthy and diseased states. Up to 3 years of funding is available. Mentor: Ivan Rusyn (TAMU). Co-mentors: Igor Pogribny (NCTR); Weihsueh Chiu (TAMU); David Threadgill (TAMU) -
Postdoctoral Research AssociateTexas A&M University Aug 2014 - Sep 2015College Station, Tx, UsWorking under Dr. Ivan Rusyn on various projects concerning trichloroethylene- and perchloroethylene-associated toxicity. Some projects will be using a mouse population model (Collaborative Cross) in order to characterize inter-individual variability in susceptibility to environmental toxicants as a consequence of genetic background. These studies will include assessing toxicokinetics and toxicodynamics relationships of these chemicals in each mouse strain. We will also apply Bayesian-based physiologically-based pharmacokinetic (PBPK) modeling to understand population variability in toxicokinetics of these chemicals.
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Graduate StudentUniversity Of Connecticut Jul 2010 - Jul 2014Storrs, Ct, UsI was previously a graduate student at the University of Connecticut working under Dr. John Morris. The Morris lab is interested in inhalation toxicology, specifically with modeling dosimetry of inhaled vapors along the entire respiratory tract. My personal project in the Morris lab was to investigate the acute respiratory tract response to inhaled electrophilic air pollutants. To investigate these responses, we used an in vivo rodent model and analyze respiratory tract tissues for cellular thiol content, mRNA/protein levels of antioxidant/proinflammatory genes, and histopathological markers of cytotoxicity. Our current model electrophiles are naphthalene, 2,3-butanedione (diacetyl), and acrolein, all of which have intrinsically different electrophilic properties. As the delivered dose of inhaled material can differ between proximal and distal airways, CFD-PBPK modeling can be used to estimate site-specific delivered dose of toxicant, which permits an airway-to-airway dose-response comparison upon normalization for delivered dose. This allows us to better understand the responsiveness of individual airways to inhaled electrophilic vapors in vivo. -
Boehringer IngelheimBoehringer Ingelheim Jun 2013 - Aug 2013Ingelheim Am Rhein, Rhineland-Palatinate, DeSummer Intern- Drug Metabolism and PharmacokineticsMy summer internship project involved high-throughput screening of potential UGT inhibitors utilizing in vitro metabolism assays and LC-MS/MS. The overall goal was to identify isoform-specific UGT inhibitors in order to improve in vitro metabolism phenotyping for future drug candidates.
Joe Cichocki Skills
Joe Cichocki Education Details
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University Of ConnecticutPharmacology And Toxicology -
University Of ConnecticutMinor In Molecular And Cellular Biology
Frequently Asked Questions about Joe Cichocki
What company does Joe Cichocki work for?
Joe Cichocki works for Vertex Pharmaceuticals
What is Joe Cichocki's role at the current company?
Joe Cichocki's current role is Regulatory Toxicologist at Vertex Pharmaceuticals.
What is Joe Cichocki's email address?
Joe Cichocki's email address is jo****@****onn.edu
What is Joe Cichocki's direct phone number?
Joe Cichocki's direct phone number is +186048*****
What schools did Joe Cichocki attend?
Joe Cichocki attended University Of Connecticut, University Of Connecticut.
What skills is Joe Cichocki known for?
Joe Cichocki has skills like Pharmacokinetics, Hplc, Toxicology, Mass Spectrometry.
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