Joe Segal, Phd Email and Phone Number
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Sr Scientist 1, Pharmacology / Toxicology at BioMarin Pharmaceutical Inc.Innovative and well-published scientist with broad expertise in molecular cell biology, human liver biology and single cell genomics. Experienced toxicologist in large-molecule drug development and knowledgeable about GLP policies and regulatory nonclinical testing requirements for pharmaceutical development of biotherapeutics. I also lead investigative toxicology research to understand mechanisms of drug and target mediated toxicity for the most promising therapeutic drug candidates for treatment of a wide range of diseases, including metabolic diseases, oncology and immune oncology. I enjoy working in a multi-disciplinary collaborative environment, where my leadership skills and enthusiasm will help drive scientific innovation for the development of new therapies to improve human health.
Biomarin Pharmaceutical Inc.
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Sr Scientist 1, Pharmacology / ToxicologyBiomarin Pharmaceutical Inc. May 2023 - PresentSan Rafael, Ca, Us
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Senior Scientist ToxicologyNgm Biopharmaceuticals Mar 2022 - May 2023South San Francisco, Ca, Us -
Investigative ToxicologistNgm Biopharmaceuticals Aug 2020 - Mar 2022South San Francisco, Ca, Us
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Postdoctoral ScholarUniversity Of California, San Francisco Aug 2018 - Aug 2020San Francisco, California, UsPostdoctoral Scholar in the Wang lab at UCSF. My work focuses on establishing the role of hepatocyte stem cells in mouse and human liver development and during regeneration after injury. • Researching the cellular heterogeneity in mouse and human liver biology during ageing and injury.• Developing a pipeline for single cell analysis involving scRNA-seq, computational analysis, in situ spatial transcriptomics, and software-based quantification. • Performing in vivo liver disease modeling and AAV based genetic editing for cell lineage tracing experiments to study cell behavior during homeostasis and injury. Relevant skills include: - Bulk and scRNA-seq data processing and analysis- Spatial transcriptomics- 2D & 3D cell culture- Flow cytometry- Mouse handling & husbandry- AAV gene editing -
Postdoctoral Research AssociateKing'S College London Jan 2016 - Jul 2018London, Greater London, GbPost doctoral research associate in Stem cell liver therapy in the Centre for Stem Cells & Regenerative Medicine at King’s College London. My work here used single cell RNA sequencing to identify a true human fetal liver stem cell population to support the development of of IPSC-derived hepatocytes for cell therapy. This research led to a first author publication at Nature communications. Other work • Designed and executed experiments to understand the transcriptional networks driving human hepatocyte maturation from ESCs and IPSCs.• Used functional genomics to identify molecular pathways that could be targeted during stem cell directed differentiation and validated using, lentiviral infection, RT-PR, ELISA and imaging.• Developed Bash and R customs scripts to analyze and interpret single cell data.Relevant skills include: - ES & iPS cell culture- Bulk and scRNA-seq- 3D Organoid culture- Primary tissue processing- Confocal imaging analysis -
Intellectual Property Assistant, University Of Salford, Salford, Uk Aug 2015 – Dec 2015The University Of Salford Aug 2015 - Dec 2015Salford, Greater Manchester, Gb• Responsible for the management and exploitation of Intellectual Property generated by research at the University of Salford.• Evaluated and assisted researchers in securing commercial funding in a range of research areas including drug design, medical tools and software development.• Completed TT reports, patent searches and engaged with companies/ investment groups to source financial support for commercializing research. -
Phd StudentUniversity Of Manchester Sep 2011 - Dec 2015Manchester, Gb• Independently designed experiments using extensive culture of embryonic and induced pluripotent stem cells, flow cytometry, RNA-sequencing, and other molecular biology techniques. • Fellow for University of Manchester Intellectual property, assessing the commercial potential of scientific research to augment the capability of the University of Manchester’s technology transfer mission.• Served as the events director and consultant for Oxbridge Biotech Roundtable, organizing and chairing biotechnology events to attract academic, industry, and clinical delegates to promote interaction in the life science community. -
ConsultantOxbridge Biotech Roundtable Jun 2014 - Sep 2014• Team member of a project aiming to reveal advantages, limitations, and critical success factors of business models, networks and partnerships in the diagnostics sector.• Identify and engage with key opinion leaders and stakeholders.• Present recommendations to the client on network/consortia models that should be employed in the future. -
Events Director (Manchester Chapter)Oxbridge Biotech Roundtable Jul 2013 - Jun 2014• Served as the events director and consultant for Oxbridge Biotech Roundtable, organizing and chairing biotechnology events to attract academic, industry, and clinical delegates to promote interaction in the life science community.
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Outreach And Marketing Lead (Manchester Chapter)Oxbridge Biotech Roundtable Jan 2013 - Jul 2013
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Umip FellowUmip Jul 2013 - Jul 2014Manchester, GbThe Fellows programme is an initiative launched by UMIP for PhD students to complete various assignments to augment the capability of the University of Manchester’s technology transfer mission.Completed regular assignments to assess the commercial potential of scientific research and gained a strong understanding of business development in a scientific environment. -
Industrial Placement StudentLonza Jul 2009 - Jul 2010Basel, Ch
Joe Segal, Phd Skills
Joe Segal, Phd Education Details
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The University Of ManchesterStem Cell Biology -
University Of BirminghamGeneral
Frequently Asked Questions about Joe Segal, Phd
What company does Joe Segal, Phd work for?
Joe Segal, Phd works for Biomarin Pharmaceutical Inc.
What is Joe Segal, Phd's role at the current company?
Joe Segal, Phd's current role is Sr Scientist, Pharmacology / Toxicology at BioMarin Pharmaceutical Inc..
What is Joe Segal, Phd's email address?
Joe Segal, Phd's email address is js****@****bio.com
What schools did Joe Segal, Phd attend?
Joe Segal, Phd attended The University Of Manchester, University Of Birmingham.
What skills is Joe Segal, Phd known for?
Joe Segal, Phd has skills like Protein Purification, Cell Culture, Molecular Biology, Western Blotting, Cell Biology, Stem Cells, Laboratory, Science.
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