Lifecycle management of chemical processes:Development of chemical processes and / or process changes.Enhancement of support systems for chemical processes.

Technical Support Service provided for bulk active pharmaceutical ingredient chemical processes and products.

Technical Support Service provided for bulk active pharmaceutical ingredient chemical processes and products.

Responsibilities included process development and process support of analgesics. These analgesics encompass natural products, semi-synthetic products and total synthetic products. Technical support for these included:CHEMISTRYplant scale process troubleshootingdeveloping process changes for cost reduction, safety improvement, reliability improvement and environmental impact improvementraw material / new supplier evaluationsynthesis, isolation and identification of process impurities synthesis of chemical reference standardsindividual contributor for numerous process improvementslead teams for several process development / process improvementsCHEMISTRY REPRESENTATIVE ON THE FOLLOWING TEAMS:laboratory safety and committee chairchemical incident investigationpre- chemical process scale-up safety reviewsincident investigations - human injury and chemical eventsoperational excellencechemical process validation

• Developed alternate process routes to the sweetener known as neotame, an N-alkyl dipeptide ester which is about 10,000 times sweeter than table sugar.• Developed an innovative purification strategy for neotame based on physical property difference of isomers.• Managed an academic collaboration.• Developed a defensive patent strategy for neotame.

• Discovered and developed processes for new polymers derived from polysuccinimide and poly(aspartic acid) which are effective and biodegradable alternatives to polyacrylate materials.• Managed the scale-up lab and personnel.

• Synthesized peptides for the chelation of rhenium and technetium and the attachment of these chelators to biologically active peptides (nuclear medicine). • Functionalized polymers for the stabilization of particles useful in blood pool imaging (magnetic resonance imaging).