Joel Bruegger Email and Phone Number
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- Self-motivated, highly productive protein scientist with experience in developing biologics.- Skilled at designing, implementing and analyzing protein-based mechanism of action studies.- I have expertise in protein engineering, purification, and analysis that includes biophysical, structural, oxidative, and functional characterization.- I communicate key concepts to team members with various backgrounds, personalities and skill sets. - My past performance demonstrates an ability to multi-task while keeping focused on strategic goals and managing the energy of my group to help develop high-performing teams that succeed and keep projects on time and budget.
Parvus Therapeutics Inc
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Director Of Protein Sciences And Process DevelopmentParvus Therapeutics Inc Feb 2023 - PresentSouth San Francisco, California, Us
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Associate Director Of Protein Science And Process DevelopmentParvus Therapeutics Inc Aug 2021 - PresentSouth San Francisco, California, Us- Leader in Technical Operations with the planning and generation of materials to support platform development. - Manages and runs experiments involving protein production, conjugation, product analysis, and process development activities.- Manages projects with partners, CRO's and CMO's.
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Senior ScientistParvus Therapeutics Inc Sep 2019 - Aug 2021South San Francisco, California, Us- Group leader of the planning, engineering, and implementation of protein production. - Drove the initial development activities of biologics for autoimmune disease therapies.- Successfully streamlined efficient protein expression, purification, and conjugation procedures.- Developed and executed protein analytical assays that lead to improved control over protein thermal stability, oxidation state, conjugation potential, and candidate selection.
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Scientist I-Ii, EnzymologyBioelectron Technology Corporation Jul 2017 - Jul 2019• Designed, implemented and analyzed mechanism of action studies between compounds and enzyme targets.• Developed activity assays utilized in high-throughput screening applications.• Accomplishments included cell-free identification of the primary enzyme target of the company’s lead compound and its mode of inhibition. This was followed by pipeline compound interaction studies.• Established and implemented in-house protein expression and purification capabilities.
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Postdoctoral Research FellowUc Berkeley May 2015 - Jun 2017Berkeley, Ca, UsPostdoctoral research accomplishing 3 first or co-first author publications.Adviser: Dr. Michael Marletta.Awarded George E. Hewitt Foundation for Medical Research Fellow.• Identified and characterized metabolic enzyme targets of S-nitrosation utilizing a comparison between proteomic and metabolomic profiles of eNOS knockout mouse organs.• Further characterized protein targets using mutagenesis, LC-MS/MS and enzyme activity assays.• Cloned, expressed, purified, and analytically characterized over 30 protein constructs.• Solved crystal structures of ligand-bound states of gas-binding heme-proteins involved in O2/NO signaling. -
Research AssociateThe Scripps Research Institute Sep 2013 - Apr 2015La Jolla, California, UsAdviser: Dr. Michael Marletta.George E. Hewitt Foundation for Medical Research Fellow.The same work, project and adviser as at U.C. Berkeley. The lab moved from TSRI to U.C. Berkeley in May, 2015. -
Phd In Biological SciencesUc Irvine Aug 2007 - Aug 2013Irvine, Ca, UsGraduate student research, resulting in 5 publications.Adviser: Dr. Sheryl Tsai• Designed probes to mimic unstable natural product intermediates to study protein-protein and protein- substrate interactions between carrier proteins and FAS/PKS enzyme partners.• Engineered reverse stereospecificity in ketoreductase proteins using crystal structures and catalytic analysis.• Engineered unnatural protein-protein and carbon chain-length specificity of PKS/FAS enzymes. -
Research AssistantHitachi Chemical Diagnostics, Inc Aug 2005 - May 2007Involved in development of an in vitro diagnostic device that quantitatively determines a patient's reaction to allergens. This included work with human blood serum, testing of allergens and optimization of the testing device, IgE and reagent qualification and data analysis.
Joel Bruegger Skills
Joel Bruegger Education Details
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Uc IrvineBiological Sciences -
University Of California, DavisBiochemistry And Molecular Biology
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College Of San MateoGeneral
Frequently Asked Questions about Joel Bruegger
What company does Joel Bruegger work for?
Joel Bruegger works for Parvus Therapeutics Inc
What is Joel Bruegger's role at the current company?
Joel Bruegger's current role is Director of Protein Science and Process Development at Parvus Therapeutics Inc.
What is Joel Bruegger's email address?
Joel Bruegger's email address is jj****@****ail.com
What is Joel Bruegger's direct phone number?
Joel Bruegger's direct phone number is +165026*****
What schools did Joel Bruegger attend?
Joel Bruegger attended Uc Irvine, University Of California, Davis, College Of San Mateo.
What skills is Joel Bruegger known for?
Joel Bruegger has skills like X Ray Crystallography, Protein Purification, Enzyme Kinetics, Molecular Biology, Western Blotting, Protein Expression, Biochemistry, Protein Engineering, In Vitro, Hplc, Homology Modeling, Isothermal Titration Calorimetry.
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