Joseph Siegel Email & Phone Number

Boston, Ma, Us

Boston, Ma, Us

Dublin, Ireland, Ie

• Develop assay and related substances, cleanout, dissolution, and water content methods for drug substances• Design, execute, and author reports for liquid chromatography and gas chromatography method validations• Support API synthesis development by monitoring reaction progression with chromatography and mass spectrometry• Participate in the due diligence of potential partnerships as the drug substance analytical representative by reviewing all analytical information pertaining to the drug substance and contributing to the authoring of the technical section of the due diligence risk assessment• Assist with root determinations for Out-of-Specification investigations• Author templates for validated methods, validation protocols, and validation reports• Perform recertification testing for reference standards

Rahway, New Jersey, Us

Rahway, New Jersey, Us

• Serve as analytical lead for a variety of unique and novel dosage forms• Supervise and mentor interns and contractors• Drive the development of pharmaceutical products through collaboration at a team and function level with the key deliverables: • Designed and executed the transfer of methods to a commercial site for release testing • Led the development of a guidance document that covered extractable and leachable studies during product development • Designed and led the investigation into biorelevant dissolution applications • Implemented a guidance for electronic lab notebooks for compliant documentation• Design and execute stability studies for prototype development, clinical stability, and registration stability batches• Author scientific technical reports and guidances to effectively document and communicate analytical results as well as improve business and scientific practices• Design and oversee the execution of experiments at contract research organizations and acting as the point of contact for troubleshooting studies• Develop assay and degradation products, content uniformity, dose accuracy, dissolution, water content, particle size, and density methods for the analysis of drug products• Utilize a variety of analytical instrumentation, including LC-UV/Vis, LC-CAD, App II, and LC-MS

Lawrence, Ks, Us

• Developed microchip electrophoresis-based methods with electrochemical and fluorescencedetection to monitor cellular nitrosative stress under neurodegenerative conditions• Engineered a decoupler that allows for electrochemical detection in a single cell analysis device• Collaborated with a research group at Kansas State University to design and test a single cellanalysis device to study the variation of small molecule production due to cellularheterogeneity• Evaluated the effectiveness of a novel fluorescent probe to detect intracellular peroxynitrite• Authored and published scientific articles and a book chapter• Mentored undergraduate and graduate students

St. Louis, Missouri, Us

•Supported various research groups by testing for trace metals using inductively coupled plasma with mass spectrometry (ICP-MS)•Assisted with metal corrosion research•Prepared various samples for ICP-MS analysis using a variety of techniques, including microwave digestion and ashing•Maintained the atomic spectroscopy laboratory and instrumentation•Trained new employees to work in the metals lab

Fridley, Minnesota, Us

•Tested raw materials for St. Louis Covidien plant•Analyzed samples with high performance liquid chromatography, infrared spectroscopy, flame atomic absorbance spectrometer, and thin layer chromatography•Performed extensive data analysis involving integrating chromatograms created by HPLC using Total Chrom software•Followed current GMP procedures•Troubleshot various instruments in order to continue optimal operation•Peer reviewed the reports of other analysts within the raw materials group

Fridley, Minnesota, Us

•Provided QC support for an in-house pharmaceuticals production plant•Prepared various types of samples for different measurement methods, including High Performance Liquid Chromatography, Gas Chromatography, and Karl Fisher•Followed current GMP procedures•Performed extensive data analysis involving integrating chromatograms created by HPLC and GC using Total Chrom software•Maintained HPLC pumps and injector•Troubleshot various instruments in order to continue operation•Peer reviewed the reports of other analysts within the QC group

Kirksville, Mo, Us

•Constructed an automatic flow injection valve for a homemade cold vapor atomic absorption spectrophotometer (CVAAS)•Determined the mercury content in the skin of fish with the CVAAS•Investigated approaches to decrease the detection limit of the CVAAS system

Kirksville, Mo, Us

East Lansing, Mi, Us

•Developed a method to quantify the concentration of ATP released by red blood cells under in vivo conditions using microfluidic technology•Modified the current microfluidic technology used in the lab to measure ATP•Developed a procedure to use a 96 well plate reader as the detection source for a microfluidic device

Doctor Of Philosophy (Phd), Analytical Chemistry

Bachelor Of Science, Chemistry