As a discovery ADME project lead i provide DMPK guidance in support of discovery teams across therapeutic areas and modalities, from portfolio entry through NME declaration.

I am an associate DMPK representative in small molecule drug discovery projects (Ro5 & bRo5) with a subject matter expert role in permeability (blood-brain barrier, intestinal drug absorption), driving in vitro - ex vivo & in vivo model validation for drug permeability assessment and implementation in project decision making.

Performing preclinical mechanistic research to answer project-related questions and implement novel strategies to ameliorate decision making and attrition. Currently I am involved in multiple projects to improve understanding of:- Drug brain disposition- Enzymology - Drug metabolism- Drug absorption with a focus on special populations

Performing preclinical mechanistic research to support project-related questions and implement novel strategies to ameliorate decision making and attrition. Currently I am involved in investigating metabolic elimination, transporter-mediated disposition (brain) and working on a project to improve understanding of intestinal drug absorption.

During this project, complementary lab tools to predict hepatic drug elimination were integrated and compared to enable a better understanding of (intracellular) unbound drug disposition from differences in tool characteristics. Subsequently, by applying these in vitro tools to drugs with different routes of hepatic elimination, we improved our knowledge on how these routes of elimination interact and which ones were crucial to improve drug elimination predictions. Finally, understanding gained during this project was extrapolated to the pediatric population for drugs which are subject to improvement with regard to evidence based dosing.