John Daub, Ph.D. Email & Phone Number

Wilmington, DE, US

Wilmington, DE

Specializing in one-on-one and small group consulting for solving research problems impacting R&D programs; and training/mentoring laboratory employees or university students organic chemistry and related fields of chemistry. Specialties include organic synthesis, physical organic chemistry, structure elucidation, NMR interpretation, MS interpretation.

Newark, DE

• Developed technical packages for preparations of radiolabeled compounds, requested quotes from contract research companies in the USA, Great Britain and India, and then provided recommendations regarding quote.
• Management award for improved cost/yield synthesis of a 14C-labeled dicloromezotiaz metabolite.
• Added non-US based contract research companies to the quote process. Resulted in up to $250,000 annual savings for radiolabeled compound synthesis.

Newark, DE

• Performed metabolite structure elucidation and total synthesis thereof. Led 4 Ph.D. Principal Investigators and several B.S. chemists as Group Leader of the Structure Elucidation Team.
• Peer nominated for award for resolution of structure of a photoproduct of thifensulfuron-methyl; this work resolved a 25 year-old, unsolved metabolite problem in response to an EU inquiry.
• Designed and developed a series of chemical reactions which produce putative metabolites for API candidates. This series of reactions saves much time in preparing and identifying metabolites.

Dover, DE

Developed and taught graduate level Bioorganic Chemistry, 2010.Taught undergraduate level Forensic Chemistry, 2012.

Newark, DE

• Developed chemical processes and solved process problems. Manager of impurity and metabolite preparations at contract research facilities in India. Trained and developed contract chemist.
• Co-inventor of WO 2013/085686 patent application for process to oxathiapiprolin.

Newark, DE

• Designed and synthesized novel chemicals as insecticides and supervised two B.S. chemists.
• Prepared analogs which led to identification of afoxolaner (marketed by Merial as NexGard ®) as an oral flea and tick control agent.

Newark, DE

• Led project teams in R&D, marketing and operations.
• Managed project to design and develop animal health screen for discovery of oral flea and tick products (DMADV approach). Successful implementation discovered new lead area with oral activity leading directly to.
• Managed several improvement projects using Six Sigma DMAIC approach including herbicide marketing, process costs, supply chain, lab automation, and contracting process work to India.

Newark, DE

• Led group of 7 Ph.D. and B.S. chemists to synthesize sub-kilogram to kilogram quantities of product development candidates.
• Designed and developed this new group dedicated to the intermediate scale-up of potential development candidates. Trained team of chemists in chemical safety and scale-up of processes.
• Received management award for process improvements developed for a kilogram scale-up toward aminocyclopyrachlor.

Wilmington, DE

• Performed metabolite structure elucidation on the Structure Elucidation Team and total synthesis thereof, and hapten design and synthesis for antibody generation. Team Leader of the Structure Elucidation Team with 4.
• Management award for structure elucidation of critical metabolite of nicosulfuron resulting in rapid EPA approval of new product.

B.A., Chemistry

Activities and Societies: Phi Beta Kappa, Sigma Xi, Golf Team, Laboratory Teaching Assistant, TutorSumma cum laude The Rena Gurley.

Doctor Of Philosophy (Ph.D.), Organic Chemistry

Activities and Societies: Teaching Assistant, Assistant Golf CoachNational Science Foundation Graduate Fellowship Award Dissertation.

Postdoctoral Fellow, Physical Organic Chemistry

National Institutes of Health Post-Doctoral Fellowship Award Research Project: Kinetics and Stereoselectivity of a Retro-Ene Reaction