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Drug discovery professional with group and project leader experience in the biopharmaceutical industry focusing on CNS, CV and skeletal muscle discovery research in indications ranging from neurodevelopmental and neurodegenerative disorders, genetic cardiomyopathies and muscular dystrophies. Biology lead for multiple programs and experience with building and leading discovery groups ranging from 5-15 scientists. Experience with therapeutic candidate discovery and optimization across several modalities including gene therapy, small molecule, antisense oligonucleotides, and antibodies. Neuronal and cardiac cell model expertise with primary rodent cultures, patient iPSC-derived cells and genetically-engineered cell lines for disease phenotyping and rescue. Assay development and optimization experience with multiple electrophysiology and high content imaging platforms. Experience with analysis and visualization of large data sets using tools such as MATLAB and Spotfire. Previous involvement with new CNS and CV indication search and evaluation efforts. Familiarity with designing new research lab space and helping to coordinate lab moves.
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Senior Director, Gene TherapySarepta Therapeutics May 2022 - PresentCambridge, Ma, Us -
Layoff/Position EliminatedCareer Break Mar 2022 - May 2022
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Senior DirectorStridebio, Inc Jan 2021 - Mar 2022Durham, North Carolina, Us -
Director, Therapeutic DiscoveryStridebio, Inc Jun 2020 - Jan 2021Durham, North Carolina, Us
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Associate DirectorFulcrum Therapeutics Feb 2019 - Jun 2020Cambridge, Massachusetts, Us -
Principal ScientistFulcrum Therapeutics Jan 2017 - Feb 2019Cambridge, Massachusetts, Us
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Senior Research InvestigatorBristol-Myers Squibb Oct 2014 - Jan 2017Lawrence Township, Nj, Us -
Research Investigator IiBristol-Myers Squibb Apr 2013 - Sep 2014Lawrence Township, Nj, Us
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Applications ScientistAxion Biosystems Jan 2013 - Apr 2013Atlanta, Ga, Us -
Adjunct Assistant ProfessorWake Forest University Jul 2010 - Apr 2013Winston-Salem, Nc, UsI have experience lecturing to graduate students, medical students and neurology residents on the following topics:Introduction to Neuroscience Role of Corticothalamic Feedback in Visual Processing Vision: Geniculocortical Processes and Superior ColliculusBiomimeticsClinical Neurophysiology NeurotransmissionMolecular Neuroscience Voltage-gated Ion ChannelsIonotropic and Metabotropic Receptors -
Rjr-Leon Golberg Postdoctoral Research FellowWake Forest University Mar 2010 - Jul 2010Winston-Salem, Nc, UsResearch topic – The regulation and modulation of ion channel function in endothelial cells by nicotine and its implication in vascular tone.
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Scientist IiiTargacept, Inc. Jul 2010 - Dec 2012Winston-Salem, Nc, UsResponsibilities and activities:- Designed and developed technology for recording neuronal activity in a multiple brain slice preparation. Currently mentoring post-doctoral research fellow responsible for implementing and designing experiments for both basic research and compound screening - Project Manager for Parkinson’s Disease program- Member of various committees to provide expertise on the practicality and viability of in vitro assays for several different central nervous system disorders- Create and maintain monthly journal club meetings to discuss new and relevant publications in the neuroscience field- Managed interns and lab technicians within the electrophysiology lab -
InternTargacept, Inc. Apr 2007 - Jun 2007Winston-Salem, Nc, UsI helped to establish an electrophysiology paradigm for the high-thoughput screening of drugs that functionally bind to nicotinic receptors in the brain.
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Fisheries BiologistNorthwest Observers, Inc. Apr 2001 - Nov 2004Worked as a fisheries biologist gathering biological data aboard commerical fishing vessels off the coast of Alaska, Washington and Oregon.
John Graef Skills
John Graef Education Details
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Wake Forest University School Of MedicineNeuroscience -
Miami UniversityNeuroscience
Frequently Asked Questions about John Graef
What company does John Graef work for?
John Graef works for Sarepta Therapeutics
What is John Graef's role at the current company?
John Graef's current role is Senior Director, Gene Therapy.
What is John Graef's email address?
John Graef's email address is jg****@****bmc.edu
What is John Graef's direct phone number?
John Graef's direct phone number is +133646*****
What schools did John Graef attend?
John Graef attended Wake Forest University School Of Medicine, Miami University.
What are some of John Graef's interests?
John Graef has interest in Playing Guitar, Restoring Volkswagon Vans.
What skills is John Graef known for?
John Graef has skills like Neuroscience, Electrophysiology, Ion Channels, Pharmacology, Cell, Drug Discovery, Cell Culture, In Vitro, Biotechnology, Neuropharmacology, Physiology, Life Sciences.
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