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Proven leader and self-starter with extensive experience across a wide range of therapeutic areas leadingand managing scientists with diverse backgrounds. A strong track record of leading projects from initial idea to IND-enabling studies. Expert in lead finding and lead optimization as exemplified impactful scientific contributions to drug discovery programs and >20 patents.
Revolution Medicines
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Vp Structural Chemistry And Discovery SciencesRevolution Medicines Feb 2023 - PresentRedwood City, California, Us-Lead three talented teams of diverse scientists spanning Computational Chemistry, Structural Biology and Discovery Sciences- Project team leader for a research project that successfully led to nomination of development candidate RMC-9805-Project team leader for a RAS(ON) project
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Exec. Dir, Sr. Dir, Dir Head Of Structural Chemistry And Discovery SciencesRevolution Medicines Sep 2019 - Feb 2023Redwood City, California, Us-Lead three talented teams of diverse scientists spanning Computational Chemistry, Structural Biology and Discovery Sciences- Project team leader for a research project that successfully led to nomination of development candidate RMC-9805- Project team leader for development candidate RMC-9805 in IND-enabling studies- Co-inventor of >5 development stage assets - SBDD across portfolio of projects
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Associate Director, Computational ChemistryIdeaya Biosciences Oct 2018 - Sep 2019South San Francisco, California, Us* co-inventor of a clinical stage asset* Responsible for Re-establishing computational chemistry discipline* Medicinal chemistry lead for discovery program Hit Finding/LO -
Computational ChemistAchaogen Sep 2017 - Sep 2018South San Francisco, Ca, Us· Responsible for establishing computational chemistry discipline· Program leader for a novel antibacterial target up to lead discovery· Computational chemistry support for drug discovery group focused on gram negative antibiotics· Key member on research informatics revamp team responsible for replacing research informaticsplatform for all of R&D· Managed a team of interdisciplinary scientists including medicinal chemistry and research informatics· Established FTE x-ray crystallography at CRO to support all of research -
Sr Research Scientist IGilead Sciences Jul 2013 - Sep 2017Foster City, Ca, Us* Program leader for a cross site oncology program *Co-inventor on multiple development candidates and 1 clinical stage compound*Computational chemistry support for a variety of projects across several therapeutic areas including anti-viral, oncology and cardiovascular.* Core team member representing structural chemistry on several programs. -
Principal ScientistGlaxosmithkline Jan 2007 - Jun 2013Brentford, Middlesex, Gb• Sole computational chemistry support for entire site (>20 chemists), using both ligand and structure based design techniques in support of projects from lead generation to lead optimization in the CNS area.• Chemistry leader for early stage programs, activities include Target assessment and lead generation strategy, HTS workup with evaluation of analogues and design of synthetic targets to further SAR, understanding of IP space, determine developabilty profile and set desired compound profile for indicated disease.• Led multiple FBDD efforts in support of a larger program, responsible for coordinating a cross-site matrix team of crystallographers, biophysical analyst and chemists in order to design and prioritize fragment evolution.• Analysis and Triage of multiple HTS/MTS in support of generating lead compounds for programs, including phenotypical screening where determination of the targets was aided by computational resource.• Design of focused libraries of compounds based on target need and assay capacity, including biological pathway and chemical diversity criteria.• Heavily involved in working with Biologist to find novel targets by searching for tool compounds, competitor information (patents and clinical trials), and evaluating experiments needed for target validation• Coordinator for information searching around current portfolio targets (patents, clinical information, meetings and clinical trials)• Facilitate training on chemical discovery software for synthetic chemists and beta-testing of software prior to rollout.• Direct line management of 6-month student placements (synthetic chemist and computational chemist)• Design and synthesize at least one compound a year in order to stay current and embed further with the medicinal chemists.• First aide, CPR, AED and Dräger Breathing Apparatus Trained to provide emergency response to accidents on the site -
Postdoctoral Fellow - Computational ChemistryNovartis Institute For Tropical Diseases Feb 2005 - Nov 2006• Structure and Ligand based design of inhibitors for infectious diseaseenzymes (Dengue & TB)• Generation of new chemical starting points using virtual screening and de novo design against targets of interest• Ligand based design of known inhibitors to improve potency• Homology modeling of related Flavivirus proteins to understand relationshipof HCV, Yellow Fever and Dengue inhibitors• Analysis and triage of HTS data
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Summer Intern And Student AssistantPfizer May 2003 - Dec 2004New York, New York, UsPfizer Discovery Tech, Ann Arbor MI USAUnder the Supervision of Lakshmi Narasimhan• Testing and optimization of docking protocols used by the department basedon structural class of protein (FRED, Gold, FlexX)• Improvements to scoring function and hit return rates using composite scoresand naive Bayesian classifiers
John Knox, Ph.D. Skills
John Knox, Ph.D. Education Details
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Wayne State UniversityChemistry (Quantum And Computational) -
York College Of PennsylvaniaChemistry (Mathematics Minor)
Frequently Asked Questions about John Knox, Ph.D.
What company does John Knox, Ph.D. work for?
John Knox, Ph.D. works for Revolution Medicines
What is John Knox, Ph.D.'s role at the current company?
John Knox, Ph.D.'s current role is Vice President, Structural Chemistry and Discovery Sciences at REVOLUTION Medicines.
What is John Knox, Ph.D.'s email address?
John Knox, Ph.D.'s email address is jo****@****nes.com
What is John Knox, Ph.D.'s direct phone number?
John Knox, Ph.D.'s direct phone number is +141581*****
What schools did John Knox, Ph.D. attend?
John Knox, Ph.D. attended Wayne State University, York College Of Pennsylvania.
What skills is John Knox, Ph.D. known for?
John Knox, Ph.D. has skills like Drug Design, Computational Chemistry, Chemistry, Data Analysis, Virtual Screening, Science, Purification, Nmr, Protein Expression.
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