John Newcomb Email and Phone Number
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Experienced molecular cell biologist, group and project leader conducting preclinical small- and large-molecule drug discovery in the fields of oncology and inflammation. A proven record at implementing research strategy and managing multi-disciplinary scientific programs. Experienced in establishing and conducting research partnerships with biopharmaceutical, CRO and University collaborators. Recognized for strong scientific and technical ability, leadership and communication skills. Areas of research expertise include:Oncology: Receptor tyrosine kinase-mediated signal transduction; Wnt-pathway activation and differentiation in cancer cells; Tumor metabolism and energy regulation; Chromatin modifiers and epigenetics.Immunology: Immune receptor-mediated signal transduction; T-cell, B-cell and mast cell activation; Cytokine production and response; Antigen processing and presentation.Specialties: Molecular Cell BiologyOncologySignal transductionDrug DiscoveryInflammation
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Head Of Drug DiscoveryDynamic Cell Therapies, Inc.Cambridge, Ma, Us -
Head Of Drug DiscoveryDynamic Cell Therapies, Inc. Feb 2022 - PresentWatertown, Ma, Us -
Head Of Drug DiscoveryDynamic Cell Therapies, Inc. Mar 2021 - PresentWatertown, Ma, Us -
Director, Head Of Molecular And Cellular OncologyTakeda Pharmaceuticals Jul 2013 - Mar 2021Tokyo, Jp -
Director, Head Of Molecular And Cellular OncologyMillennium Pharmaceuticals Jul 2012 - Mar 2021Cambridge, Ma, Us -
Director, ResearchAmgen 2006 - Dec 2011Thousand Oaks, Ca, UsHematology/Oncology Therapeutic Area – Responsible for a group of scientists involved in multiple small and large molecule pre-clinical drug discovery projects.• Experienced in project stages from target validation through lead candidate optimization and characterization, including development of pharmacodynamic biomarker assays.• Discovered and advanced novel inhibitors for 5 different targets• Researched, proposed and implemented a multi-target discovery platform in a novel area for the company• Serve on technical review committee to guide portfolio for global discovery research in oncology• Responsible for performance review and career development of staff• Provide leadership and mentoring for the group, including 5 Ph.D. level scientists and project leaders• Evaluate scientific direction and project target selection for the group -
Associate Director, ResearchAmgen 2004 - 2006Thousand Oaks, Ca, UsEstablished the foundation for the Hematology/Oncology therapeutic area group at Amgen, Cambridge, MA. Recruited scientists and served as the main point of contact with senior leadership -
Research Scientist IvAmgen 2002 - 2004Thousand Oaks, Ca, UsCellular Screening Group Leader and project leader for multiple small molecule drug discovery projects in inflammation and cancer therapeutic areas -
Research Scientist IiiAmgen 2000 - 2002Thousand Oaks, Ca, UsLed interdisciplinary drug discovery project teams targeting EGF-R and IGF-1R receptor tyrosine kinases for oncology indications. Novel and potent small molecule inhibitors were identified. -
Sr. ScientistKinetix Pharmaceuticals Mar 1998 - Dec 2000Responsible for building cell biology and cell-based compound screening capabilities at a start-up small molecule biopharmaceutical company focused on discovery and development of novel kinase inhibitors. Managed relationships with CRO’s to obtain PK and in vivo efficacy data. Company was successful at building value in several cancer and inflammation projects and was purchased by Amgen in 2000.
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Principal InvestigatorProcept, Inc. 1994 - 1998Project leader for small molecule immunosuppressive program. Managed scientific collaboration with Novartis.
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Howard Hughes FellowYale University School Of Medicine Feb 1991 - Feb 1994New Haven, Ct, UsStudied the role of Invariant chain in antigen processing and presentation by MHC class II molecules.
John Newcomb Skills
John Newcomb Education Details
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Temple University - Lewis Katz School Of MedicineMicrobiology And Immunology -
University Of DelawareBiology
Frequently Asked Questions about John Newcomb
What company does John Newcomb work for?
John Newcomb works for Dynamic Cell Therapies, Inc.
What is John Newcomb's role at the current company?
John Newcomb's current role is Head of Drug Discovery.
What is John Newcomb's email address?
John Newcomb's email address is jo****@****eda.com
What is John Newcomb's direct phone number?
John Newcomb's direct phone number is +161744*****
What schools did John Newcomb attend?
John Newcomb attended Temple University - Lewis Katz School Of Medicine, University Of Delaware.
What skills is John Newcomb known for?
John Newcomb has skills like Drug Discovery, Oncology, Inflammation, Group Leader, Project Leader, Pre Clinical Drug Discovery, Molecular Cell Biology, Cell Based Assay Development, Pharmacodynamic Biomarker Assay Development.
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