John Umland Email & Phone Number

Waterford, Ct, Us

Framingham, Massachusetts, United States

Supervising two junior scientists who screen multi-species liver microsome and hepatocyte metabolic stability assays for clients from large pharma, biotech, and research labs using Sciex Xeno TOF-MS.● Performing quality control of all data generated by my lab before sending to clients using the opportunity to train the junior scientists in scientific decision making.● Assisting other lab heads in quality control of other ADME assays as part of load sharing when needed. ● Actively participating in the daily maintenance and quality control of the QTOF. ● Enabling client requests for customized assays.● Anticipating the needs of new biotechs with suggestions on which assays will address the ADME needs of their target or chemical space.● Meeting with potential customers, explaining our ADME and Toxicology scientific assays.● Contributing to internal cost analysis for our services based on customization and throughput requested.

Groton, Connecticut

Led comprehensive initiatives, ensuring superior insourced and outsourced data quality focusing on precision and reliability. Point of contact and ADME liaison for brain and tissue transporter screening – data curation, assays communication via presentations and internal SharePoint. ADME in vitro evaluation of large (Protein degraders, macrocycles) and small molecules with metabolic stability, passive permeability, and transporter substrate, uptake, and inhibition assays.• Oversaw and evaluated CRO oversight in China and England, ensuring project team satisfaction with high quality and weekly turnaround and troubleshooting of assays with team TCs. Responsible for all data QC before data release to internal database. Visited sites in Shanghai for CRO training and troubleshooting resulting in a 20% decrease in repeated assays.• Delivers active and passive whole cell permeability, protein binding, blood to plasma ratio, and microsome and plasma stability data with active input to project teams on results to guide projects forward. • Develops hepatic uptake and transporter inhibitor assays.• Provides in-source training on transporter assays, covering cell culture, biology, mass spectrometry, and data review, resulting in a highly skilled team and improved assay consistency.• Improves dynamic range of passive permeability assay for poorly permeable and Bro5 compounds by 50% with assay modifications.• Manages contracted resources for cell culture, active and passive permeability assays, lipophilicity, and microsome stability assays, leading to reduction in overall project costs.

Groton, Connecticut, United States

• Consistent delivery of HTS ADME data with minimal oversight and high quality. • Innovated transporter cell culture resulting in reduction of nonsense data by 10%.• Delivered single point and multi-point DDI.• Developed hepatocyte uptake assay.• Coordinated and presented at monthly ADME education sessions.

Groton, Connecticut, United States

• Assay development and prosecution of asthma and inflammation targets using:o Receptor Binding, Enzyme inhibition, Enzyme and receptor biochemistry and pharmacology o via HPLC, ELISA, RIA, SPA, Flashplate• High-Throughput Screening: enzymes, isolated receptors, membranes, whole cells