John Darby Email & Phone Number

Oxford, GB

Oxford, Oxfordshire, GB

Oxford, Oxfordshire, GB

Delivery and interpretation of surface plasmon resonance (SPR) data to drug discovery project teams. Characterisation of affinity, binding kinetics, and specificity of candidate molecules and antibodies.My role also encompasses line managing junior scientists, lab supply logistics, equipment maintenance, and sharing my scientific knowledge and experience.

Oxford, Oxfordshire, GB

Sheffield, South Yorkshire, GB

Bill & Melinda Gates Foundation funded proof-of-concept project to investigate endonuclease enzymes for therapeutic inhibition in tuberculosis and malaria. We are using fragment-based drug discovery (FBDD) approaches to identify starting points for drug development.

York, GB

Employed as a Post-doctoral researcher using X-ray crystallography and NMR to discover and investigate small molecule glycoside hydrolase activators and inhibitors using fragment-based ligand discovery (FBLD) approaches.Carried out detailed isothermal titration calorimetry (ITC) studies to probe the role of water in ligand binding.

London, GB

Solution NMR studies on human SGTA to determine protein structure and define interaction interfaces with UBL domains. Models of the protein complexes were obtained using HADDOCK.

London, Greater London, GB

Utilised biochemical screening to identify potential inhibitors of a challenging protein-protein interaction. Further structural and biophysical investigation of promising compounds was achieved by protein NMR. The utility of TPR cochaperones as drug targets explored using RNAi techniques. Finally, the solution structure of the protein target was solved.

Racine, WI, US

Assessment of chemicals under EU legislation in order to flag potential areas of non-compliance.

London, GB

Assisted the directors of a growing opinion research firm, pollsters for the Times newspaper. Provided research briefs for directors on a diverse range of topics.

Doctor Of Philosophy - Phd

Msci, Chemistry