John Darby Email and Phone Number
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Experienced research leader generating laboratory data for AI-driven science. Trained at the Institute of Cancer Research and Imperial College London.Google Scholar:https://tinyurl.com/jfdarby
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XymeOxford, Gb -
Principal ScientistXyme Sep 2024 - Present
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Associate Director BiophysicsExscientia Mar 2024 - Jul 2024Oxford, Oxfordshire, Gb -
Senior Biophysical Drug Discovery ScientistExscientia Jan 2022 - Apr 2024Oxford, Oxfordshire, GbDelivery and interpretation of surface plasmon resonance (SPR) data to drug discovery project teams. Characterisation of affinity, binding kinetics, and specificity of candidate molecules and antibodies.My role also encompasses line managing junior scientists, lab supply logistics, equipment maintenance, and sharing my scientific knowledge and experience with my colleagues.
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Biophysical Drug Discovery ScientistExscientia May 2021 - Dec 2021Oxford, Oxfordshire, Gb
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Postdoctoral ResearcherThe University Of Sheffield Oct 2019 - May 2021Sheffield, South Yorkshire, GbBill & Melinda Gates Foundation funded proof-of-concept project to investigate endonuclease enzymes for therapeutic inhibition in tuberculosis and malaria. We are using fragment-based drug discovery (FBDD) approaches to identify starting points for drug development. -
Postdoctoral Research FellowUniversity Of York May 2013 - Oct 2019York, GbEmployed as a Post-doctoral researcher using X-ray crystallography and NMR to discover and investigate small molecule glycoside hydrolase activators and inhibitors using fragment-based ligand discovery (FBLD) approaches.Carried out detailed isothermal titration calorimetry (ITC) studies to probe the role of water in ligand binding. -
Postdoctoral Research AssociateImperial College London Jan 2013 - Apr 2013London, GbSolution NMR studies on human SGTA to determine protein structure and define interaction interfaces with UBL domains. Models of the protein complexes were obtained using HADDOCK. -
Phd StudentInstitute Of Cancer Research Oct 2008 - Dec 2012London, Greater London, GbUtilised biochemical screening to identify potential inhibitors of a challenging protein-protein interaction. Further structural and biophysical investigation of promising compounds was achieved by protein NMR. The utility of TPR cochaperones as drug targets explored using RNAi techniques. Finally, the solution structure of the protein target was solved using NMR. -
Regulatory Affairs AssistantSc Johnson Oct 2007 - Jun 2008Racine, Wi, UsAssessment of chemicals under EU legislation in order to flag potential areas of non-compliance. -
InternPopulus Limited Sep 2006 - Sep 2006London, GbAssisted the directors of a growing opinion research firm, pollsters for the Times newspaper. Provided research briefs for directors on a diverse range of topics.
John Darby Skills
John Darby Education Details
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The Institute Of Cancer ResearchDoctor Of Philosophy - Phd -
Imperial College LondonChemistry
Frequently Asked Questions about John Darby
What company does John Darby work for?
John Darby works for Xyme
What is John Darby's role at the current company?
John Darby's current role is Biophysics | Enzymology | Protein design | Drug discovery.
What is John Darby's email address?
John Darby's email address is jo****@****ail.com
What schools did John Darby attend?
John Darby attended The Institute Of Cancer Research, Imperial College London.
What skills is John Darby known for?
John Darby has skills like Cancer Research, Western Blotting, Molecular Pharmacology, Protein Structure, Protein Production, Cell Culture, Drug Discovery, Molecular Biology, Lifesciences, High Throughput, Biophysical Chemistry, Protein Assays.
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