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Experienced Scientist with a demonstrated history of working in the pharmaceuticals industry. Skilled in Protein Engineering, Antibody and CAR Engineering, Cell Therapy, Genome Editing, Synthetic Biology, Structural Biology, and 20+ years of working on receptors, GPCRs, and other membrane proteins. Strong research professional with a PhD focused in Biochemistry from University of California, Berkeley.
Samsung Bioepis
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Vice President, Enable TeamSamsung BioepisCalifornia, United States
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Vice President, BiotherapeuticsEnsocell Mar 2024 - Present -
Discovery Biotherapeutics, Protein EngineerExelixis Jan 2023 - Mar 2024Alameda, California, Us -
Senior DirectorMetagenomi Jul 2022 - Dec 2022Emeryville, California, Us -
Senior DirectorKyverna Therapeutics Nov 2021 - Jun 2022Emeryville, California, Us -
DirectorKyverna Therapeutics Feb 2020 - Oct 2021Emeryville, California, Us
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Staff ScientistKyverna Therapeutics Mar 2019 - Feb 2020Emeryville, California, UsApplying synthetic biology and protein/antibody/chimeric antigen receptor (CAR) engineering to develop cell therapies to cure serious autoimmune diseases.
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Scientist 3Bristol-Myers Squibb Aug 2016 - Mar 2019Lawrence Township, Nj, UsProtein Engineering, Antibody Engineering, Antibody Humanization/Affinity Maturation, Phage Display, Receptors, GPCRs, Structural Biology -
Research Assistant ProfessorUniversity Of Minnesota Jun 2010 - Aug 2016Minneapolis And St. Paul, Minnesota, UsMembrane protein crystallography, Structural studies of Calcium ATPase in complex with novel activators and inhibitors, DNA-protein complexes, FRET based drug discovery Selected Publications:1. T. Bohl, K. Shi, J.K. Lee & H Aihara. Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli. Nature Comm 9: 377 (2018)2. Y. Zhang, J.K. Lee, E.A. Toso, J.S. Lee, S.H. Choi, M. Slattery, H. Aihara, M. Kyba. DNA-binding sequence specificity of DUX4. Skelet Muscle. 6:8 (2016)3. M.W. Murphy*, J.K. Lee*, S. Rojo, M.D. Gearhart, K. Kurahashi, S. Banerjee, G.A. Loeuille, A. Bashamboo, K. McElreavey, D. Zarkower, H. Aihara, V. Bardwell. An ancient protein-DNA interaction underlying metazoan sex determination. Nature Struct Mol Biol. 22(6), 442-451 (2015) *equal contribution to work.4. P.S. Chae*, R.R. Rana, K. Gotfryd, S.G. Rasmussen, A.C. Kruse, K.H. Cho, S. Capaldi, E. Carlsson, B. Kobilka, C. Loland, U. Gether, S. Banerjee, B. Byrne*, J.K. Lee*, and S.H. Gellman*. Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study. Chem Comm. (2012) *corresponding authors -
Research Biochemist / Academic CoordinatorUcsf Feb 2008 - Jun 2010San Francisco, California, Us-Lead scientist for collaborations between Membrane Protein Expression Center and corporate collaborators for the expression, purification, and crystallization of human ion-channels, receptors, and transporters -Leadership team of MPEC and CSMP for evaluation, strategy, and establishing collaborations -Development and optimization of methods for the expression, purification, and crystallization of prokaryotic and eukaryotic integral membrane proteins in HEK293s, E. coli, yeast, and insect cells Selected Publications:1. L.E. Metzger*, J.K. Lee*, J.M. Finer-Moore, C.R.H. Raetz, and R.M. Stroud. LpxI structures reveal how a lipid A precursor is synthesized. Nature Struct Mol Biol 19, (2012). *equal contribution to work. 2. F. De Angelis*, J.K. Lee*, J.D. O'Connell III, L.J. Miercke, K.H. Verschueren, V. Srinivasan, C. Bauvois, C. Govaerts, J. Ruysschaert, R.M. Stroud, and G. Vandenbussche. Crystal structure and metal binding properties of ZneB from Cupriavidus metallidurans. Proc Natl Acad Sci USA.107 (2010). *equal work3. J.K. Lee and R.M. Stroud. Unlocking the eukaryotic membrane protein structural proteome. Curr Opin Struct Biol 20 (2010).4. Z.E. Newby, J.D. O’Connell III, F. Gruswitz, F.A. Hays, W.E. Harries, I.M. Harwood, J.D. Ho, J.K. Lee, D.F. Savage, L.J. Miercke, and R.M. Stroud. A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nature Protocols 4 (2009). -
Postdoctoral ScholarUcsf Jun 2002 - Jan 2008San Francisco, California, UsStructure and Function of Membrane ProteinsSelected Publications:1. J.K. Lee, G.I. Belogrudov, R.M. Stroud. Crystal structure of bovine mitochondrial factor B at 0.96-Å resolution. Proc Natl Acad Sci USA 106 (2008).2. Z. Du, J.K. Lee, R. Tjhen, R.M. Stroud, T.L. James. Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage. Proc Natl Acad Sci USA 105 (2008).3. S. Fenn, Z. Du, J.K. Lee, R. Tjhen, R.M. Stroud, T.L. James. Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 Å resolution. Nucleic Acids Research 35, 2651-2660 (2007).4. J.K. Lee, D. Kozono, J. Remis, Y. Kitagawa, P. Agre, and R.M. Stroud. Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 Å. Proc Natl Acad Sci USA 102 (2005).5. J.K. Lee, S. Khademi, W. Harries, D. Savage, L. Miercke, and R.M. Stroud. Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family. J Synchrotron Radiat 11 (2004).
John Kyongwon Lee Skills
John Kyongwon Lee Education Details
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University Of California, San FranciscoBiochemistry & Biophysics -
University Of California, BerkeleyBiochemistry
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University Of California, BerkeleyMolecular And Cell Biology
Frequently Asked Questions about John Kyongwon Lee
What company does John Kyongwon Lee work for?
John Kyongwon Lee works for Samsung Bioepis
What is John Kyongwon Lee's role at the current company?
John Kyongwon Lee's current role is Vice President, Enable Team.
What is John Kyongwon Lee's email address?
John Kyongwon Lee's email address is jl****@****atx.com
What is John Kyongwon Lee's direct phone number?
John Kyongwon Lee's direct phone number is +161237*****
What schools did John Kyongwon Lee attend?
John Kyongwon Lee attended University Of California, San Francisco, University Of California, Berkeley, University Of California, Berkeley.
What skills is John Kyongwon Lee known for?
John Kyongwon Lee has skills like Protein Chemistry, Biochemistry, Molecular Biology, Protein Purification, X Ray Crystallography, Western Blotting, Protein Expression, Pcr, Purification, Dna, Drug Discovery, Molecular Cloning.
Who are John Kyongwon Lee's colleagues?
John Kyongwon Lee's colleagues are Heejun Jang, Seokhwan Choi, Yujin Lee, Gyeongmin Yun, Jaeil K., Sangmin Ahn, Beatrice Jang.
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