Patent ExaminerPharmaceutical Compositions; Art Unit 1615GS-9 (May 2023-April 2024)GS-11 (April 2024-present)• Patent Training Academy 5/2023-9/2023• Proficient in searching databases for relevant prior art• Evaluated patent applications by comparing them to prior art• Understanding of all 112, 101, 102, and 103 issues• Compose Office Actions• Respond to applicants based on docket ordering• Checking applications for compliance with formal requirements of patent statutes and rules along with technological accuracy• Treating disclosure statements and claims of priority• Conducting search• Analyzing disclosure and claims for compliance with 35 USC 112• Planning field of search• Making proper rejections under 35 USC 102 and 103 with supporting rationale, or determining how claim(s) distinguish over the prior art• Determining whether amendment introduces new matter• Appropriately formulating restriction requirements, where application could be restricted• Determining whether the claimed invention is in compliance with 35 USC 101• Determining where appropriate line of patentable distinction is maintained between applications and/or patents

The journal aims:1. to publish all the latest and outstanding developments in both Analytical and Pharmaceutical Research2. to publish original articles, reviews, letters, and guest edited single topic issues on all aspects of research in the field - Promoted the Journal of Analytical & Pharmaceutical Research - Served as a reviewer of publication articles

Aim:Journal of Chemical Science and Chemical Engineering is dedicated to publishing high-quality papers that describe the most significant and cutting-edge research in all areas of chemistry. As well as reflecting the traditional core subjects of analytical, inorganic, organic and physical chemistry, the journal also features a broad range of chemical research including catalysis, computational and theoretical chemistry, environmental chemistry, green chemistry, medicinal chemistry, nuclear chemistry, polymer chemistry, supramolecular chemistry and surface chemistry.In addition to primary research, JCSCE also publishes review articles, news and views, research highlights about important work reported in other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical picture.JCSCE is committed to publishing top-tier original research in all areas of chemistry through a fair and rigorous review process. It offers authors high visibility for their papers, access to a broad readership, high standards of copy editing and production, rapid publication and independence from academic societies and others with vested interests.Scope:Analytical chemistry, including new techniques and instrumentationBiochemistry and medicinal chemistryInorganic chemistry, including main group, transition metal, and f- block compounds, as well as coordination, organometallic, and solid state chemistryMaterials chemistry of hard and soft matter, from the nanoscale upwardsNuclear chemistry and radioactivityOrganic chemistry, including synthesis, characterisation, and properties of organic compounds, as well as study of organic reactions and their mechanisms Physical chemistry and chemical physicsSustainable, green, and environmental chemistryTheoretical and computational chemistry- Promoted Journal of Chemical Science and Chemical Engineering- Served as a reviewer of publication articles

Aims & Scope:The Open Natural Products Journal publishes original research articles, reviews, letters and guest edited single topic issues on all aspects of research and development in the field including: isolation, purification, structure elucidation, synthesis and bioactivity of chemical compounds found in nature.The Open Natural Products Journal, a peer reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality articles rapidly and freely available worldwide.- Promoted The Open Journal of Natural Products- Served as a reviewer of publication articles

Archives of Nanomedicine: Open Access Journal (ANOAJ) is a peer reviewed scientific journal meant for professionals and researchers in Nanomedicine and Nanotechnology. This journal publishes high quality original articles, review articles, case reports, short communications, etc. It is an international, peer-reviewed journal presenting significant, novel, interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life sciences. Content includes basic, clinical research addressing diagnosis, treatment, monitoring, prediction, translational and prevention of diseases. This journal covers a wide range of categories such as molecular nanotechnology, nanosensors, nano particles, nanodrugs, drug delivery, nanomaterials, nanobiotechnology, nanobiopharmaceutics, nanoelectronics, nano-devices, nanorobotics etc. The potential scope of nanomedicine is broad, and we expect it to eventually involve all aspects of medicine. Sub-categories include synthesis, bioavailability and biodistribution of nanomedicines; delivery, pharmacodynamics, and pharmacokinetics of nanomedicines; imaging; diagnostics; improved therapeutics; innovative biomaterials; interactions of nanomaterials with cells, tissues, and living organisms; regenerative medicine; public health; toxicology; point of care monitoring; nutrition; nanomedical devices; prosthetics; biomimetics; and bioinformatics. It invites all type of High Quality articles such as Editorial, Research Articles, Short Communications, Opinion Articles, Review Articles, Case Reports. We invite authors to submit original manuscripts in these categories.- Promoted the Archives of Nanomedicine: Open Access Journal- Served as a reviewer of publication articles

 Law – IP Department • Operated within the IP department to support internal and external patent attorneys (6 month assignment)• Responded to Office Actions • Evaluated the prosecution history of a patent application to pursue a Request for Continued Examination (RCE)• Consulted with patent attorneys and inventors to draft patent applications• Interviewed with examiners to discuss patent applications• Reviewed, edited, and formatted patent applications using Track Changes in MS Word• Analyzed claims to ensure complete disclosure in the specification• Conducted patent and literature searches using both Questel (Orbit Intelligence) and SciFinder• Participated in the Internal Global Invention Disclosure Review evaluating R&D IP Chemistry – Specialty Chemicals and Engineering Materials Division• Worked as part of the R&D Team on internal high profile material science and pharmaceutical projects using Design of Experiment techniques • Compiled and organized the 2022 Business Continuity Plan for the Scotia, NY Site• Synthesized and characterized organosilanes and silicones in an ISO-certified laboratory (100 g to Multi kg scale)• Composed a Process Hazard Assessment (PHA) for all synthetic procedures• Completed the Management Achievement Program for leaders • Presented internal seminars and reported R&D progress in weekly updates• Certified on the identification of hazardous waste in compliance with the Resource Conservation and Recovery Act (RCRA)• Updated and maintained ISO format for various procedure• Maintained laboratory safety • LinkedIn Learning Short Courses:o Audit and Due Diligence: Priorities and Best Practices o Six Sigma Foundationso Lean Six Sigma: Define and Measure Toolso Lean Six Sigma: Analyze, Improve, and Control Toolso Statistics Foundations: The Basicso Process Improvement Foundationso Root Cause Analysis: Getting to the Root of Business Problems• Obtained a Six Sigma Yellow Belt

• Custom synthesis for advanced intermediates

• Responded to the USPTO in the form of Office Actions, Continuation Applications, Preliminary Amendments, and 1.312 Amendments (Post Notice of Allowance) dealing with the mechanical and electrical arts • Communicated with patent attorneys and patent agents

• Consulted with a client on 101, 102, and 103 matters in Albany, NY• Attended the PLI short course entitled, “Patent Eligibility, Prior Art and Obviousness 2018: Current Trends in Sections 101, 102, and 103”• Communicated with patent attorneys, patent agents, and legal interns• Presented a seminar on “Obviousness in Pharmaceutical Inventions”

• Developed novel thermoplastics available for transfer from the lab scale to a pilot plant

• Lead a team of research scientists in the development of cutting-edge polymer chemistry merged with organic chemistry techniques • Improved economics of the companyo Organized lab space and equipmento Increased efficiency of laboratory operationso Implemented 5S Lean criteriao Officiated a move of chemistry laboratories to a new location • Communicated research results and development ideas to major company investors• Developed novel pathways to form cyclic resins having ultra-low viscosity making them suitable for low-pressure processes such as casting, rotational molding, and composite processing methods. Possible applications: automotive and aircraft parts, sports equipment, luggage, and others.• Utilized both homogeneous and heterogeneous catalysts to generate resins• Evaluated synthetic pathways using a DoE approach • Performed statistical analysis to evaluate chemistry pathways (Yates Algorithm, Factorial Design, Factor Effect Plots, and Response Surface Analysis)• Initiated and designed experiments based on results to transition from batch to continuous process• Optimized reaction rates• Assembled steel microscale reactors using Swagelok and pipe fittings • Balanced administrative duties such as EH&S inspections, waste removal, approving timecard submissions, visiting vendors, and submitting research samples to customers • Reviewed the safety protocol for all employees

• Improved economics of the company• Analyzed polyurethane mixtures used in a process to convert recycled rubber into usable materials with various additives to determine the optimal cure rate for an enhanced process.• Used both graphical and statistical analysis to process cure rates at a given temperature• Manufactured and evaluated prototype parts based on optimal polyurethane amounts

- Furnished, evaluated, and purified synthetic targets integral to the success of a medicinal chemistry CNS project, as a project leader- Supervised 4-6 medicinal chemists- Generated targets based on the evolving SAR and SPR- Maintained SAR/SPR spreadsheets of the bioassay data- Distributed targets to reports based on their strengths. Our team synthesized >2000 analogues over a 5 year period- Prepared >200 g of a preclinical candidate (team)- Familiar with formulation techniques, ADMET analysis, and in vitro/in vivo PK- Integral on the technical transfer of the medicinal chemistry synthetic route to the chemical development department- Acted as medicinal chemistry consultant for global projects- Presented research results via written reports, oral reports, and slide presentations- Served as Safety Coordinator and inspected labs for 5S Lean/Continuous Improvement compliance- Attended internal chemistry short courses; Penetration of the Blood Brain Barrier, Designing Drugs with Optimal In Vivo Activity After Oral Administration, ADME, In Vitro Approaches for the Evaluation of Human Drug Properties: Absorption, Metabolism, Drug-Drug Interactions, and Toxicity, Organometallic Chemistry, The Directed ortho Metalation (DoM) Reaction in Organic Synthesis, Progress in C-C and C-Heteroatom Bond-Forming Reactions, and Varian HPLC operation- Management training (DDI)

- Furnished, evaluated, and purified synthetic targets integral to the success of medicinal chemistry projects (CNS, Cardiovascular Disease, and Oncology)- Maintained a biological database for a CNS project integrating MS Excel, ChemFinder, MS Access, and ISIS Base- Presented research results at semi-annual project review and weekly group meetings and composed quarterly experimental reports and slides summarizing synthetic progress- Served as Safety Coordinator and inspected laboratories for safety compliance- Interviewed and evaluated Ph.D. and B.S candidates for synthetic organic chemistry research position- Supervised and evaluated staff- Maintained the Varian 1200L Quadrupole LC-MS for the Medicinal Chemistry Department

- Furnished synthetic targets having >98% HPLC and combustion analysis purity for external biological testing, and reviewed documentation for shipment associated with the Certificate of Analysis.- Purified final targets by preparative HPLC, chiral separartion, combi-flash, and column chromatography- Evaluated synthetic products using structure elucidation techniques including 2-D/1-D NMR, HPLC, LC-MS, FT-IR, EIMS, APCI, HRFAB-MS, TOF-MS, UV-Vis, and OR - Synthesized combinatorial chemistry building blocks for an aspartyl protease library (5 g scale)- Produced 1 g of a CDK inhibitor (oncology) for additional PK testing- Afforded 1 g a G-CSF mimetic analogue- Presented research results at semi-annual project review and weekly group meetings and composed quarterly experimental reports and slides summarizing synthetic progress

- Synthesized the marine natural product, Phakellistatin 11, a cyclic octapeptide via solid-phase peptide synthesis- Prepared numerous N-methylated amino acids - Operated and maintained the 9050 Plus PepSynthesizer (working knowledge of amino acids, coupling agents, and protecting groups in both solid-phase and solution-phase peptide synthesis

- Synthesized the prodrug and various other diphosphate salts of Combretastatin (CS) A-1, an antineoplastic stilbene natural product. (The IP for the CS A-1 prodrug was purchased by Oxigene and it is currently in Phase I clinical trials.)- Performed microscale asymmetric syntheses for structure-activity relationship (SAR) studies on derivatives of Combretastatin A-1- Produced 15g of Combretastatin A-4 prodrug for Phase I Clinical Trials (99% HPLC purity)- Optimized and conducted the scale-up synthesis, 50g, of Combretastatin A-1