John Mac Email & Phone Number

San Diego, California, US

San Diego, California, US

San Diego, California, US

• Led process development studies involving bioreactors, electroporation, cryopreservation, T cell purification, and new materials.
• Developed scale-down model for allogeneic processes to enable more efficient materials testing and process understanding studies.
• Presented findings to senior leadership and drafted reviewed technical reports to support process changes in clinical manufacturing.
• Worked cross-functionally on donor screening initiatives with R&D and data science departments.
• Characterized cytokine profiles of patient-derived CAR T cells.
• Coordinated studies with external collaborators to evaluate novel electroporation programs.

• Screened and identified target-specific T cell receptors (TCR) for cancer immunotherapy.
• Characterized the specificity and safety profile of TCRs for IND applications.
• Produced MHC tetramers for TCR screening and validation.
• Expressed, purified, and characterized antibodies.
• Drafted and reviewed standard operating procedures for the research and quality departments.

Los Angeles, CA, US

• Co-advised by Professors Pin Wang and Richard Roberts.
• Determined efficacy of chimeric antigen receptor T (CAR-T) cells and immunotoxin combination therapy
• Used mRNA display to select for peptide ligands of STAT3
• Identified masking sequences for chimeric antigen receptors with mRNA Display

Thousand Oaks, CA, US

• Optimized the generation of antibody F(ab')2 fragments from intact antibodies
• Developed a protocol to screen reducing conditions necessary to produce chemically-reactive Fab' fragments from F(ab')2 fragments
• Improved siRNA alkylation efficiency from 80% to greater than 95%

Ph.D, Chemical Engineering

Bachelor Of Science (B.S.), Chemical Engineering