John Murphy Email & Phone Number

Dartford, United Kingdom

Queenborough, Kent

Provides secondary manufacturing support to new business development activities and to support existing commercial products manufactured at Aesica Queenborough on a technical basis. The scope includes execution of the following activities:New product introduction / transfer (Solid dosage and liquid)Resolution of process related issues including Granulation, Compression and CoatingProcess Optimisation and Yield ImprovementProcess / equipment changes as identified to facilitate cost reductionAppropriate reprocessing or rework activitiesValidation change control relating to changes in product formulations, process, equipment or raw material changes.Liaison with External Customers including Product License Holders, Regulatory Authorities, Raw Material Suppliers, Equipment and Consumables Suppliers.Liaison with Internal Customers including Corporate, Regulatory, QPs, QA Audit, Production, Validation, QC, QA Documentation, Purchasing, Planning, Development, Engineering, ITProduce batch manufacturing documentation in support of new product introduction or major changes to routine batch manufacture.Identify new ancillary equipment as required, for example compression tooling (working closely with iHolland to identify special requirements for tooling coating), making recommendations on , filters and meshes and analytical testing equipment.Taking lead for introduction of tooling management system within Aesica across multiple compression areas.Provided NIR support for introduction of new product onto a continuous manufacturing process.Provides product validation protocols and summary reports.Improve established processing to ensure optimum quality, increased yields and improved health and safety practices. Be available as subject matter expert as required during audits and for product impact assessments.Seconded to the High Capacity Manufacturing Facility to provide Technical support to help with outstanding CAPA’s and compression related issues.

Dartford, Kent

Investigates non-conforming and non-standard batches.Manages projects for process improvementProvides a problem solving service for dispersion products.Interacts closely with Manufacturing and Quality Control.Uses critical thinking, analytical and problem solving skills to progress projects and continuous improvement.Prepares equipment performance qualification / raw material validation & stability test protocols as well as subsequent reports.

Process Technical Support within the Global Quality Group

A highly motivated, versatile and experienced Senior Pharmaceutical Technician with a proven track record of success and thorough technical & theoretical understanding of Oral Drug Product formulation and processing. Primarily responsible for resolving manufacturing challenges for commercial and R&D products within both Abbott and Third Party Manufacturing Affiliates at pilot and commercial scale.Lead Technical Support for introduction of new products, and for process improvements and transfers to existing products. Includes transfer of new product entities into contained potent drug plant. Resulted in improved granulation, drying and compression process and successful manufacture of Clinical Trials Batches.Resolved manufacturing issues for commercial and R&D products. Performs a range of technical process trouble-shooting issues at both Affiliate and Third Party Manufacturers. This has resulted in continuous batch to batch manufacture with no OOS failures. Also resulted in the successful Validation of transferred processes.Recognized as highly skilled at Validation and Engineering batches at Abbott and TPM's for product transfer because of process and equipment knowledge and previous manufacturing experience.Managed the Pilot Plant facility, responsible for internal GMP Audits, Lock-out and Tag out system, purchase of equipment and tooling, booking-in of product materials, creation of Equipment and Room Log-Book system, responsible for facility cleaning schedule. This lead to a fully operational Pilot Plant meeting current GMP requirements

Was awarded the Presidents Award for the transfer of a Potent Compound from a traditional process to a fully contained process. This included development of process at both pilot and commercial scale using unfamiliar equipment and working in both Belgium and Ireland for extended periods. I helped develop the granulation and drying process and transferred this knowledge to commercial scale. Carried out FAT and SAT of manufacturing equipment and subsequent trouble shooting which resulted in – commercial scale fully contained process for 4 capsule strengths.Was awarded the Presidents Award for supporting development of a prototype tablet formulation for the WHO. This award was given for manufacturing a tablet to GMP requirements as cheaply as possible so that it could be provided for a third world country. I suggested a different blending technique to accommodate batch size required. – A Direct Compression process used to successfully manufacture tablets for the WHO.

Operation of Chemical Production Plant to appropriate regulatory standards, ensuring the production plan is met. Contributed to creating a lean process for the manufacture of key ingredient.

Supported the formulation and process developed of new chemical entities, including the process development of an immediate release tablet and the formulation and process development of a hard gelatin capsule using semi-automatic capsule filler. Solved assay issue during granulation and improved FBD process.Carried out experimental techniques employed to characterise pharmaceutical product including angle of repose, bulk, tapped density, friability, disintegration, particle size analysis, flow through an orifice, LOD and Karl Fischer.Manufacture clinical trial supplies to GMP for Phase II studies, including placebo product.Validated granulation end point detection system of high shear mixer.Responsible for maintenance of tooling and coating accessories in IDC.

Specialist in granulation including High Shear, Low Shear, Spray Granulation, SPP and 'V' Blender Granulation.Carried out minor maintenance on machinery, operated controls and valves, set temperatures and made adjustments throughout the manufacturing process, controlling the manufacturing operation.Prepared solutions by heating and mixing chemicals until they conformed to specifications.Gained expertise using forms of Coating equipment including Glatt and Accela Cota. Trained in compression, setup, and thorough understanding of compression operation.Licensed Fork truck driver (Counter Balance and Reach).