John R Springer Email & Phone Number

St. Louis, Mo, Us

St Louis, Missouri

St. Louis, Missouri

St. Louis, Missouri

St. Louis, Missouri

St. Louis, Missouri

Greater St. Louis Area

Experienced Synthetic Organic Chemist/Medicinal Chemist utilizing modern techniques (singleton and library design) to develop/analyze/predict Structure Activity Relationships of small molecules, examine critically the physical properties/behaviors (PK/PD) of compounds and innovatively develop plans to successfully address compound related hurdles (ADME/TOX etc.). My ability to design/synthesize has resulted in clinical candidates. Concurrent research with large molecules (Proteins… Show more Experienced Synthetic Organic Chemist/Medicinal Chemist utilizing modern techniques (singleton and library design) to develop/analyze/predict Structure Activity Relationships of small molecules, examine critically the physical properties/behaviors (PK/PD) of compounds and innovatively develop plans to successfully address compound related hurdles (ADME/TOX etc.). My ability to design/synthesize has resulted in clinical candidates. Concurrent research with large molecules (Proteins, Antibodies), has led to innovative techniques for selective bioconjugation of active biological agents to large molecules. Manage workflow for 13 Discovery and 7 Scale Synthetic Chemists in Asian, Northern Europe, and Canadian research organizations significantly affecting the project by increasing new chemical entity production by 30% and delivering >60 kilograms of chemical intermediates and final compounds required to achieve targeted goals. [30-40 rolling requests, prioritization, timelines, raws sourcing, synthetic routes, and synthesis troubleshooting via weekly telecons].Excellence in synthetic organic chemistry via multi-step synthesis (singleton/library), small and large molecule synthesis (Macrocycles/Bioconjugation) and scale-up experienced performing 50mg to >1Kg reactions for chemistry optimization, method development, and route modifications enabling multi kilogram scale focused on reducing cost, number of synthetic steps, cycle time, and increasing scalability of synthesis.Minor Capital Committee Member. Developed relationships with vendors, researched new equipment, proposed/requested capital funding, and implemented installation/training of new equipment to ensure access to cutting-edge technology for all department chemists and maximize productivity. Show less

Greater St. Louis Area

Medicinal Chemist/synthetic organic chemist utilizing modern techniques (singleton and library design) to develop/analyze/predict structure activity relationships of small molecules, examine critically the physical properties/behaviors (PK/PD) of compounds and innovatively developed plans to successfully address compound related hurdles (ADME/TOX etc.).

St. Louis, Missouri

Pharmacia - Medicinal Chemist/synthetic organic chemist utilizing modern techniques (singleton and library design) to develop/analyze/predict structure activity relationships of small molecules, examine critically the physical properties/behaviors (PK/PD) of compounds and innovatively developed plans to successfully address compound related hurdles (ADME/TOX etc.).

Greater St. Louis Area

G.D. Searle Division - Medicinal Chemist/synthetic organic chemist utilizing modern techniques (singleton and library design) to develop/analyze/predict structure activity relationships of small molecules, examine critically the physical properties/behaviors (PK/PD) of compounds and innovatively developed plans to successfully address compound related hurdles (ADME/TOX etc.).

Greater St. Louis Area

G.D.Searle (Pharmaceutical Kilo Prep Lab)• Synthesized chemical intermediates and final compounds for discovery chemists on kilogram scale from multi-step synthesis employing 22L jacketed glassware, high pressure 5 gal autoclave reactors, >300ml/min chromatographic equipment, and a variety of other large scale equipment. • Designed/conducted route improvements on gram scale as a pilot to reduce cost and synthetic steps, then transferred technology to multi kilogram… Show more G.D.Searle (Pharmaceutical Kilo Prep Lab)• Synthesized chemical intermediates and final compounds for discovery chemists on kilogram scale from multi-step synthesis employing 22L jacketed glassware, high pressure 5 gal autoclave reactors, >300ml/min chromatographic equipment, and a variety of other large scale equipment. • Designed/conducted route improvements on gram scale as a pilot to reduce cost and synthetic steps, then transferred technology to multi kilogram scale producing desired deliverables. Show less

Greater St. Louis Area

Agriculture Process Development - Conducted synthetic organic reactions, validated and initiated minor modifications to specific processes on the 1L and 22L scale to better understand untranslatable phenomena in pilot plant. Research efforts improved scalability to metric ton scale, resulting in significant cost savings to the manufacturing process of Clofencet (a wheat-hybridizing agent marketed as Genesis®).

Godfrey, Illinois

Lectured chemical biology courses and accompanying laboratories.

Edwardsville, Illinois

Synthesized carboranyl-modified fatty acids from decaborane for use in Boron Neutron Capture Therapy as a treatment for Cancer. Lectured and moderated introductory, organic, quantitative, and instrumental analysis laboratories. Organized and performed as chemistry tutor in tutor lab as well as exam grading and proctoring.

Master Of Business Administration (M.B.A.), Concentration In Process And Project Management

Master Of Science, Chemistry

Research Thesis: "Carboranyl-Modified lipids for use in Boron Neutron Capture Therapy"

Bachelor Of Arts, Chemistry, Minor In Biological Sciences