Lab:Structural Virology Laboratory

Advisory board member in the panel for Structural Bioinformatics

Structural Bioinformatics tutor specializing in teaching Computer-Aided Drug Discovery (CADD) and Molecular Dynamics Simulations (MDS) modules

Lab:Structural and Molecular Virology GroupResearch Projects:Structural characterization of the membrane proteins in Chikungunya virus:• Involved in solving the structures and carrying out further structural characterization of biosimilar antibodies and CHIKV membrane proteins predominantly the ion channel forming TF protein.• Working on aspects such as plunge freezing, grid setup, cryo-EM imaging, image processing and analysis, model building, and the overall usage of cryo-EM (State-of-the-art Titan Krios G3 300KV cryo-EM).

Lab:Integrative Structural Biology LabResearch Projects:Structural basis for host-pathogen interaction mediated by DENV EDIII domain:• Involved in protein characterization studies including molecular cloning, protein over-expression and purification, protein crystallization and structural analysis, protein-peptide interactions, and protein engineering of the DENV envelope protein (E protein), in specific, the DIII domain of E protein.• A special focus is to study the dynamics in the interaction of this viral protein with recombinant antibodies.• In addition, my research work also includes designing novel monobodies and antibody mimetics against DENV envelope protein.Molecular basis for the function of protein tyrosine phosphatase SHP2:• Involved in carrying out structural studies and investigating the functional mechanisms of tyrosine phosphatase SHP2 co-crystallized with peptides.• Working on aspects such as molecular cloning, protein overexpression, protein purification, crystallization, solving the X-Ray crystal structures, protein-peptide interactions, protein engineering, and further downstream structural studies.