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Experienced medicinal/organic chemist providing chemistry leadership for drug discovery and development. For more information about these services, please visit http://www.wetzelconsulting.com.Key services: Management of active pharmaceutical ingredient (API) and drug product manufacturingAuthoring of CMC regulatory documentsChemistry support of patent prosecutionLitigation consultingDue diligenceCompound design, synthesis and evaluationLaboratory infrastructure design and implementation Some recent client comments can be found under Recommendations, below. More are available at http://www.wetzelconsulting.com/recent_client_comments.htm.
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PrincipalWetzel Chemistry Consulting, Llc 2005 - PresentHow clients have benefited:In Drug Development:Novel active pharmaceutical ingredient (API) manufacturing processes were developedAPI and impurity structures were elucidated and impurities qualifiedAPI polymorphs were characterizedAnalytical and bioanalytical methods were developed and validatedNovel oral, dermal and parenteral formulations were developedAPIs and drug products were manufactured under cGMP, enabling clinical trialsChemistry, Manufacturing and Controls (CMC) documents were provided in support of >15 Investigational New Drug Application (IND), New Drug Application (NDA) and post-approval filings Two drugs received U.S. marketing approval Process and formulation patent applications were filed on behalf of clientsIn Drug Discovery:Several chemical series were prioritized according to their potential to yield drug-like leads for an anti-cancer targetThe binding mode, structure-activity relationships and likely sites of off-target binding were elucidated for two leading chemical seriesPredicted off-target binding was experimentally verified for several key cross-reactivity sitesTesting strategies were designed and implemented for efficient prioritization of new compounds and minimization of off-target interactionsNew analogs with improved selectivity for the desired target were identifiedPatent applications were carefully written, Examiner concerns were addressed and patents were issuedIn Litigation:Trial and deposition testimony was provided on behalf of defendant in the Hatch-Waxman Act litigation case, Hospira v Sandoz, District of New Jersey For more information, please visit http://www.wetzelconsulting.com.
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Director, Chemistry, Manufacturing And ControlsBiomimetix Aug 2018 - PresentGreenwood Village, Colorado, Us -
Visiting Assistant Professor, Department Of Chemistry & BiochemistryOhio University 2007 - 2009Athens, Ohio, Us -
Director, Chemistry Support ServicesLundbeck Research Usa 2003 - 2005Valby, Copenhagen, DkLed project teams for MCH1 antagonist discovery and Chemistry Technology Platform development.Co-led the selection of an automated storage / retrieval strategy for the Lundbeck screening collection worldwide. -
Positions Of Increasing Responsibility, Culminating In Director Of ChemistrySynaptic Pharmaceutical Corporation 1990 - 2003Managed 40 FTEs, including Medicinal, Computational, Analytical and Bioanalytical Chemists.Managed the outsourcing of Chemistry, Manufacturing and Controls (CMC) efforts for preclinical and clinical development of a novel anti-depressant, including chemical process development, GMP-compliant synthesis, GLP-compliant analysis and bioanalysis, and formulation. Contributed CMC section to IND filing and annual update.Designed and synthesized alpha-1a adrenoceptor antagonists for treatment of benign prostatic hyperplasia.Discovered the first subtype-selective alpha-1a antagonist, SNAP 5089.Discovered highly selective alpha-1d adrenoceptor antagonists exemplified by SNAP 8493.Designed and implemented a novel strategy for the efficient characterization, purification and formatting of combinatorial libraries culminating in neat solid archive samples.Developed a novel LCMS-guided HPLC purification strategy for library purification.Conducted numerous HPLC separations, including enantioselective separations and high-throughput library purifications, on milligram and gram scales.Procured and maintained NMR, LCMS, HPLC and other instruments.
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Visiting ScientistSuntory Institute For Bioorganic Research 1988 - 1990Explored the chemical relationship between the brown planthopper (Nilaparvata lugens) and its intracellular yeast-like symbiote through deuterium labeling and GCMS techniques.Advisors: Prof. Koji Nakanishi and Dr. Yoko Naya.
John Wetzel Skills
John Wetzel Education Details
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The Johns Hopkins UniversityChemistry -
Ohio UniversityChemistry
Frequently Asked Questions about John Wetzel
What company does John Wetzel work for?
John Wetzel works for Biomimetix
What is John Wetzel's role at the current company?
John Wetzel's current role is Principal, Wetzel Chemistry Consulting, LLC.
What is John Wetzel's email address?
John Wetzel's email address is pr****@****ing.com
What is John Wetzel's direct phone number?
John Wetzel's direct phone number is +174069*****
What schools did John Wetzel attend?
John Wetzel attended The Johns Hopkins University, Ohio University.
What skills is John Wetzel known for?
John Wetzel has skills like Drug Discovery, Chemistry, Organic Synthesis, Analytical Chemistry, Pharmaceutical Industry, Biotechnology, Drug Design, Lc Ms, Technology Transfer, Drug Development, Hplc, Nmr.
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