Jolinde Van Bergen Email & Phone Number

Leiderdorp, Zuid-Holland, Nederland

Munich, Bavaria, Germany

Title: “The impact of atg7 and FKBP51 in the mediobasal hypothalamus on behaviour and metabolism”. PI: dr. Mathias Schmidt, Research Group Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.This project focused on the interaction of stress-related behavioral and metabolic phenotypes in the context of psychiatric and metabolic disorders. Specifically, we aimed to decipher the interplay of the stress-regulator protein FKBP51 with cellular autophagy in the hypothalamus. This project required me to learn and apply a wide variety of different techniques, including complex behavioral tests, stereotactic surgery, various wet lab and imaging techniques, metabolic phenotyping using indirect calorimetry, and machine-learning algorithms to assess complex social behavior.Grade: 8.5/10

Leiden, Zuid-Holland, Nederland

Title: "Following the development and outcome of projects: Dutch Animal Welfare Bodies and their use of experimental work protocols"In this project, I set up and performed a qualitative study using content analysis on survey data to compare the different Dutch Animal Welfare Bodies (AWBs) with regards to their use of working protocols to monitor research projects involving laboratory animals.Abstract:As prescribed by EU Directive 2010/63, one of the responsibilities of Animal Welfare Bodies (AWBs) is to ‘follow the development and outcome of projects, taking into account the effect on the animals used, and identify and advise as regards elements that further contribute to the 3R’s’. As this directive primarily provides a general outline of this task, it is up to individual AWBs to determine how to best formalize this function. In the Netherlands, it is common practice for researchers to submit an experimental work protocol (i.e., detailed description of hypothesis-driven experiment) to the AWB prior to the start of an experiment, which allows AWBs to review the study. By subdividing a project into multiple experiments that are separately reviewed, experimental work protocols could be useful tools for AWBs to follow the development and outcome of projects. Since the protocol evaluation is not a formal task of AWBs, we were interested in the role it plays in the AWB’s responsibilities. This study has evaluated how different Dutch AWBs might follow the development and outcome of projects by means of the experimental work protocol procedure. To achieve this, a survey was sent to Dutch AWBs. Overall, we argue that the use of experimental work protocols covers nearly all aspects of the task to follow the development and outcome of projects. To cover all aspects of this task, additional strategies can be used (e.g., welfare diaries, retrospective project analyses).

Amsterdam, North Holland, Netherlands

Title: "Measuring phasic dopamine release in rats on a free choice high-fat high-sugar (fc-HFHS) diet using fast-scan cyclic voltammetry (FSCV)".PI: prof. dr. Susanne la Fleur, Department of Endocrinology & Metabolism, Amsterdam UMC location AMC; Metabolism and Reward Group, Netherlands Institute for Neuroscience (NIN) This project focused on the influence of a highly palatable choice diet on phasic dopamine release in the VMS and DLS of rats, using fast-scan cyclic voltammetry. Additionally, motivational behavior was assessed using a lever pressing task. Tasks included animal handling (rats), assisting during FSCV measurements and behavioral tests, various wet lab techniques (brain sectioning and immunohistochemistry), and data anaysis (MATLAB). Grade: 8.0/10

Leiden

Responsibilities included coaching high school students one-on-one on approaching and answering exam questions, and keeping track of the learning curve of a small group of high students by providing tailored feedback - both regarding their skills as well as their knowledge of the subject.

Leiden

Leiden, South Holland, Netherlands

Title: "Characterizing CAA-ri in D-CAA patients: a retrospective cohort study"PI: prof. dr. Marieke Wermer, Department of Vascular Neurology, Leiden University Medical CenterIn this retrospective cohort study, we aimed to investigate the prevalence and clarify the clinicoradiological characteristics of cerebral amyloid angiopathy-related inflammation (CAA-ri), a condition characterized by amyloid-β-induced cerebrovascular inflammation, in patients with Dutch-type hereditary CAA (D-CAA). My responsibilities included screening the medical records and MRI scans of D-CAA mutation carriers for clinical and radiological features of CAA-ri, respectively. Grade: 8.5/10

Leiden

Daily tasks consisted of conserving the treasury, generating income for this association, preparing financial reports, and releasing financial information. In addition, I co-managed the logistics of this organisation.

Leiden

As a member of the Year Representation, I represented second-year biomedical students of Leiden University by acting as a point of contact for teachers and students and organizing activities for the students. Individual responsibilities included evaluating and facilitating the improvement of educational courses, by writing evaluation reports and participating in evaluatory meetings with teachers and educational coordinators.

Master Of Science - Msc, Biomedical Sciences: Neurobiology, 8.2/10

Track: psychopharmacology and pathophysiology (PPP) Literature thesis (12 ECTS): Human in vitro models of microglia-neuron communication.

Master Of Arts - Ma, Philosophy, Bioethics And Health, 8.0/10

Internship (9 ECTS): 'Comparing Dutch Animal Welfare Bodies (AWBs) regarding their employment of working protocols to monitor research.

Honours Program

Bachelor Of Science - Bsc, Biomedische Wetenschappen/Biomedical Sciences

Activities and Societies: Member of student/study associations VGSL 'Franciscus Gomarus', SKC Leiden and M.F.L.S. (see.

Pre-University College

Thesis: "The influence of ΔHSC90 and ΔHSP90 on the folding of the CFTR protein in patients with cystic fibrosis" Grade: 9.0/10

Bilingual Gymnasium, 8.6/10

Activities and Societies: Pre-university college, Utrecht UniversityProfile: nature & technique, and nature & health Thesis: '.