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Jonathan Lees is listed as Research Scientist based in Rockville, Maryland, United States. AeroLeads shows a matched LinkedIn profile for Jonathan Lees.
Jonathan Lees previously worked as Research Scientist at Plantvax, Inc. and Research Consultant at Sequella, Inc.. Jonathan Lees holds Doctor Of Philosophy (Ph.D.), Biology from The Johns Hopkins University.
Jonathan Lees is a Research Scientist.
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Rockville, Md
• Purified hundreds of milligrams of proteins for therapeutic studies from plant leaves and Chinese hamster ovary (CHO) cells. • Butyrylcholinesterase and acetylcholinesterase protein to counteract organophosphates • IgG antibodies to prevent human immunodeficiency virus transmission
Rockville, Md
• Optimized the purification of a mycobacteriophage by ion-exchange chromatography to remove molecular components that would disrupt a Mycobacterium tuberculosis detection assay.
• Discovered that the mitochondrial protein Fis1 homodimerizes. • Determined the dimer topology using spectroscopic techniques. • Engineered variants using site-directed mutagenesis that disrupt or enhance Fis1 dimerization. • Applied a kinetic model to describe the dimerization of Fis1.• Found that yeast cannot respire with the Fis1 mutations suggesting that an interconversion between monomer and dimer is necessary for function.
• Showed that two small molecules, nizatidine and pyridoxine, do not interact using isothermal titration calorimetry contrary to a previous computational prediction.
• Sequenced the signal sequence of the frog myelin protein zero.• Found a carbohydrate moiety on the zebrafish myelin protein zero.• Created a human myelin protein zero variant that causes a known packing defect and optimized purification of the variant.
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Jonathan Lees is listed as Research Scientist.
Jonathan Lees is based in Rockville, Maryland, United States.
Jonathan Lees has worked for Plantvax, Inc., Sequella, Inc., Johns Hopkins University, Colby College, and Boston College.
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Jonathan Lees holds Doctor Of Philosophy (Ph.D.), Biology from The Johns Hopkins University.
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